Correction to: Treatment of adults with intracranial hemorrhage on apixaban or rivaroxaban with prothrombin complex concentrate products

Journal of Thrombosis and Thrombolysis - In the original publication of the article, unfortunately the given name and family name of the author’s in the author group were inadvertently...     

Cheap,facile, and upscalable activated carbon-based photothermal layers for solar steam generation

Solar-to-steam generation characterized by nanostructured photothermal materials and interfacial heating is developed based on various carbon nanostructures such as graphene, reduced graphene oxide, CNT, or their combinations. However, multiple and sophisticated synthetic steps are required to generate macroscopic porosity in photothermal devices for the efficient mass transport of water and generated steam. Additionally, the fabrication of photothermal layers on a practical scale constitutes the main hurdle for real applications toward solar-driven desalination. Herein, we report on the development of highly efficient photothermal layers with a commercially available low-cost material, activated carbon (AC), by using facile filtration and spray coating methods, which lead to the generation of intraparticle porous structure without any additional processing. The AC-based photothermal layers generated 1.17 kg m⁻² h⁻¹ of steam under 1 sun, and 4.7 wt% of polyethyleneimine coating on AC enhanced steam generation by 8.5% under 1 sun, corresponding to 1.27 kg m⁻² h⁻¹ of the water evaporation rate and 85.66% of the photothermal conversion efficiency. This was due to improvements in light absorption and water uptake properties with the additional advantage of mechanical robustness. The outdoor solar-to-steam generation test with the spray-coated A4-sized photothermal layer in conjunction with the desalination test demonstrated the potential for practical desalination application with upscalability.

Highly efficient photothermal layers were developed based on a commercially available low-cost material, activated carbon, which demonstrates the potential for practical desalination application with upscalability.     

Use of Critical Access Hospital Emergency Rooms by Patients With Mental Health Symptoms

CONTEXT: National data demonstrate that mental health (MH) visits to the emergency room (ER) comprise a small, but not inconsequential, proportion of all visits; however, we lack a rural picture of this issue. PURPOSE: This study investigates the use of critical access hospital (CAH) ERs by patients with MH problems to understand the role these facilities play in rural MH needs and the challenges they face. METHODS: Primary data were collected through the combination of a telephone survey and ER visit logs. Our sampling frame was the universe of CAHs at the time the survey was fielded. KEY FINDINGS: About 43% of CAHs surveyed operate in communities with no MH services, while 9.4% of all logged visits were by patients identified as having some type of MH problem. The most common problems identified were affective disorders, substance abuse, anxiety, and psychotic disorders. Only 32% of CAHs have access to on-site detoxification and 2% have inpatient psychiatric services, meaning that patients in need of these services typically must leave their communities to gain treatment. CONCLUSIONS: The lack of community resources may impact CAHs' ability to assist patients with MH problems. Among those with a primary MH condition, 21% left the ER with no or unknown treatment, as did 51% of patients whose MH condition was secondary to their emergent problem. Patients in need of detoxification or inpatient psychiatric services often must travel over an hour to obtain these services, potentially creating significant issues for themselves and their families.     

Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway

We previously identified a naturally occurring human SNP, G247R, in the third intracellular loop of the α(1a)-adrenergic receptor (α(1a)-247R) and demonstrated that constitutive expression of α(1a)-247R results in twofold increased cell proliferation compared with WT. In the present study we elucidate molecular mechanisms and signal transduction pathways responsible for increased cell proliferation unique to α(1a)-247R, but not α(1a)-WT, α(1b), or α(1d)AR subtypes. We show that elevated levels of matrix metalloproteinase-7 (MMP7) and a disintegrin and metalloproteinase-12 (ADAM12) in α(1a)-247R-expressing cells are responsible for EGF receptor (EGFR) transactivation, downstream ERK activation, and increased cell proliferation; this pathway is confirmed using MMP, EGFR, and ERK inhibitors. We demonstrate that EGFR transactivation and downstream ERK activation depends on increased shedding of heparin-binding EGF. Finally, we demonstrate that knockdown of MMP7 or β-arrestin1 by shRNAs results in attenuation of proliferation of cells expressing α(1a)-247R. Importantly, accelerated cell proliferation triggered by the α(1a)-247R is serum- and agonist-independent, providing unique evidence for constitutive active coupling to the β-arrestin1/MMP/EGFR transactivation pathway by any G protein-coupled receptor. These findings raise the possibility of a previously unexplored mechanism for sympathetically mediated human hypertension triggered by a naturally occurring human genetic variant.