全文获取类型
收费全文 | 28260篇 |
免费 | 1433篇 |
国内免费 | 140篇 |
专业分类
耳鼻咽喉 | 341篇 |
儿科学 | 495篇 |
妇产科学 | 592篇 |
基础医学 | 3604篇 |
口腔科学 | 686篇 |
临床医学 | 2047篇 |
内科学 | 7679篇 |
皮肤病学 | 437篇 |
神经病学 | 2035篇 |
特种医学 | 844篇 |
外科学 | 4954篇 |
综合类 | 121篇 |
一般理论 | 1篇 |
预防医学 | 814篇 |
眼科学 | 401篇 |
药学 | 1812篇 |
中国医学 | 43篇 |
肿瘤学 | 2927篇 |
出版年
2023年 | 141篇 |
2022年 | 297篇 |
2021年 | 518篇 |
2020年 | 279篇 |
2019年 | 338篇 |
2018年 | 494篇 |
2017年 | 376篇 |
2016年 | 477篇 |
2015年 | 503篇 |
2014年 | 647篇 |
2013年 | 834篇 |
2012年 | 1288篇 |
2011年 | 1411篇 |
2010年 | 758篇 |
2009年 | 702篇 |
2008年 | 1354篇 |
2007年 | 1389篇 |
2006年 | 1400篇 |
2005年 | 1281篇 |
2004年 | 1305篇 |
2003年 | 1294篇 |
2002年 | 1331篇 |
2001年 | 951篇 |
2000年 | 971篇 |
1999年 | 852篇 |
1998年 | 370篇 |
1997年 | 281篇 |
1996年 | 260篇 |
1995年 | 228篇 |
1994年 | 215篇 |
1993年 | 188篇 |
1992年 | 621篇 |
1991年 | 662篇 |
1990年 | 557篇 |
1989年 | 561篇 |
1988年 | 538篇 |
1987年 | 502篇 |
1986年 | 435篇 |
1985年 | 433篇 |
1984年 | 326篇 |
1983年 | 247篇 |
1979年 | 233篇 |
1978年 | 137篇 |
1977年 | 139篇 |
1974年 | 129篇 |
1973年 | 123篇 |
1972年 | 140篇 |
1971年 | 129篇 |
1969年 | 139篇 |
1967年 | 128篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Yoshiki Imamura Takahiro Shinozaki Akiko Okada‐Ogawa Noboru Noma Masahiro Shinoda Koichi Iwata Akihiko Wada Osamu Abe Kelun Wang Peter Svensson 《Journal of oral rehabilitation》2019,46(6):574-587
Burning mouth syndrome (BMS) is a chronic oro‐facial pain disorder of unknown cause. It is more common in peri‐ and post‐menopausal women, and sex hormone dysregulation is believed to be an important causative factor. Psychosocial events often trigger or exacerbate symptoms, and persons with BMS appear to be predisposed towards anxiety and depression. Atrophy of small nerve fibres in the tongue epithelium has been reported, and potential neuropathic mechanisms for BMS are now widely investigated. Historically, BMS was thought to comprise endocrinological, psychosocial and neuropathic components. Neuroprotective steroids and glial cell line–derived neurotrophic factor family ligands may have pivotal roles in the peripheral mechanisms associated with atrophy of small nerve fibres. Denervation of chorda tympani nerve fibres that innervate fungiform buds leads to alternative trigeminal innervation, which results in dysgeusia and burning pain when eating hot foods. With regard to the central mechanism of BMS, depletion of neuroprotective steroids alters the brain network–related mood and pain modulation. Peripheral mechanistic studies support the use of topical clonazepam and capsaicin for the management of BMS, and some evidence supports the use of cognitive behavioural therapy. Hormone replacement therapy may address the causes of BMS, although adverse effects prevent its use as a first‐line treatment. Selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) may have important benefits, and well‐designed controlled studies are expected. Other treatment options to be investigated include brain stimulation and TSPO (translocator protein 18 kDa) ligands. 相似文献
5.
6.
Koji Saito Takashi Saito Sumio Kawada 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1176, 1179-1176, 1180
7.
Masahiro Yamauchi Hiroko Kusano Etsuko Saito Takeshi Iwata Masashi Nakakura Yasuki Kato Takaaki Uochi Shiro Akinaga Noboru Aoki 《Journal of controlled release》2006,114(2):268-275
Previously, we demonstrated that wrapping dextran fluorescein anionic/cationic lipid complexes with neutral lipids produced a stable formulation that markedly increased the duration of the compound in plasma after intravenous administration to rats. The improved drug-delivery properties of the wrapped liposomes (WL) relative to other formulations suggested that this technology could offer important advantages for the administration of other polyanionic drugs, including antisense oligodeoxynucleotides (ODN). In the present study, we investigated the value of WL for formulating fluorescence-labeled phosphorothioated ODN (F-ODN). WL encapsulating F-ODN/cationic lipid complexes were prepared efficiently using similar methodology to that used in our earlier study. Studies confirmed that these WL were stable in vitro. Following intravenous administration to mice, free F-ODN and naked F-ODN/cationic lipid complexes were rapidly eliminated whereas administration of the WL resulted in high blood concentrations of drug that were maintained for several hours. Additional studies were conducted in mice that were inoculated with tumor cells (Caki-1 xenograft model, human kidney); in these experiments, intravenous administration of WL delivered 13 times more F-ODN to the tumor site than achieved after injection of free F-ODN. 相似文献
8.
9.
Y Ohtsuka X-T Wang J Saito T Ishida M Munakata 《The European respiratory journal》2006,28(5):1013-1019
Inter-individual variations in the development of silicosis, even within the same environments, have been reported, which suggest the contribution of genetic factors in silicosis aetiology. The aim of the present study was to determine whether there is any significant genetic influence on the development of silicosis. Furthermore, which genetic loci are responsible for the pulmonary response to silica exposure? Eight strains of inbred mice were used to examine the genetic influence on the lung fibrotic response to silica exposure. After intercross-breeding between the most susceptible and most resistant strains, a genome-wide linkage analysis of quantitative trait loci (QTL) was performed. Hydroxyproline was applied as an index, and genotypes of 167 marker genes were analysed by fragment analysis using a capillary-type sequencer. There was significant inter-strain difference in the mean concentration of hydroxyproline contents among the eight strains of mice. Breeding studies were conducted between the most susceptible, C57BL/6J, and the most resistant strain, CBA/J. A genome-wide linkage analysis of silica-exposed intercrossed cohorts identified significant QTL on chromosome 4 and suggestive QTL on chromosomes 3 and 18. The present study demonstrates that genetic factors may play a significant role in fibrotic-lung responses to silica; one significant and two suggestive quantitative trait loci were identified. 相似文献
10.
Mitsuru Takahashi Hidenobu Takahashi Tetsushi Itoh Masaharu Nomura Akihiko Ogata Sachio Maehara Harubumi Kato 《Annals of thoracic and cardiovascular surgery》2006,12(1):50-52
Postoperative empyema and aspergillosis were diagnosed in a 66-year-old man. Since non-operative therapy was not effective, we performed surgery. On the 8th postoperative day, a covered Ultraflex expandable stent (Boston Scientific, Galway, Ireland) was implanted to make a one-way airway for blocking a major air leak from a bronchopleural fistula causing respiratory distress. His general condition improved gradually, and he was discharged 30 days after stenting. In conclusion, we used a covered Ultraflex expandable stent to make an airway to block an air leak. This may be a new application for this stent. 相似文献