排序方式: 共有24条查询结果,搜索用时 15 毫秒
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目的探讨血管瘤样纤维组织细胞瘤(angiomatoid fibrous histiocytoma,AFH)的临床病理学特征、诊断及鉴别诊断。方法回顾性分析3例AFH的临床病理学特征、免疫表型及分子学检测,并复习相关文献。结果 3例患者均为女性,年龄47~63岁;主要表现为皮下或真皮缓慢生长的无痛性肿块,2例位于腹股沟区,1例位于前臂。眼观:灰白色结节,长径1.0~2.0 cm,切面呈灰白色,局灶点状灰红色,囊实性。镜检:增生的组织细胞样细胞、肌样细胞和上皮样细胞呈多结节状生长,3例均可见假血管样腔隙,2例有较厚的纤维性假包膜及周围见淋巴细胞、浆细胞浸润。免疫表型:CD68、vimentin及SMA均阳性,2例CD99、EMA阳性,CD34、desmin、CK、CD45、S-100及HMB-45均阴性,Ki-67增殖指数0~15%。分子病理:FISH法检测t(22q12)(EWSR1)阳性。结论 AFH属于较为少见的中间型(偶有转移性)肿瘤,好发于儿童和青少年,发生的位置较表浅,临床特征不明显,常被误诊为血管瘤或血肿。病理形态学特征为该病的主要诊断依据,免疫组化标记及分子检测有助于诊断及鉴别诊断。治疗方法以局部适当扩大切除为主,术后密切随访,一般预后良好。 相似文献
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This study aims to find good markers for predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Vasculogenic mimicry (VM) and the expression of hypoxia inducible factor-lα (HIF-lα)/E-cad protein in ESCC were investigated by immunostaining. The association between VM, HIF-lα/E-cad and clinicopathologic characteristics and 5-year-survival rate of patients with ESCC was analyzed. A total of 160 ESCC specimens were involved in this study and 28 specimens of normal esophageal mucosa served as controls. VM channels were identified in 78 (48.75%) of the 160 ESCC specimens and none of the normal esophageal mucosa was found to have VM. The rates of high-expression of HIF-lα and E-cad in ESCC were 43.75% and 38.75%, while the rates in control were 17.86% and 71.43%, respectively (P<0.05 for all). VM and the expression levels of HIF-lα and E-cad were significantly related to lymph node metastasis, serosa infiltration, PTNM staging and 5-year-survival rates of patients with ESCC (P<0.05 for all). VM was positively correlated with HIF-lα but negatively with E-cad, and HIF-lα was negatively correlated with E-cad (P<0.001 for all). The 5-year-survival rate of patients with ESCC was 6.41% (5/78) in VM group and 65% (52/82) in non-VM group, 7.14% (5/70) in high HIF-lα expression group and 57.78% (52/90) in low HIF-lα expression group. Oppositely, the 5-year-survival rate in high E-cad expression group was 80.65% (50/62) and that in low E-cad expression group was 7.37% (7/98) (P<0.05 for all). Cox multifactor regression analysis indicated that lymph node metastasis, PTNM stage, VM and expression levels of HIF-lα and E-cad were independent risk factors of patients with ESCC (P<0.05 for all). Combined detection of VM, HIF-lα and E-cad plays an important role in predicting the invasion, metastasis and prognosis of patients with ESCC. 相似文献
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目的 探讨软组织骨化性纤维黏液样肿瘤(ossifying fibromyxoid tumor of soft tissue,OFT)的临床病理、免疫表型特征及其诊断和鉴别诊断.方法 对2例OFT临床病理资料进行分析、光镜观察及免疫组化标记,并复习相关文献.结果 2例患者临床表现均为皮下缓慢生长的肿块.手术完整切除肿块,大体标本表面均有一层不完整的骨壳.术后病理组织学检查见肿瘤边界清楚,有纤维性假包膜,包膜内有一层薄的不连续的由成熟化生的板层骨构成的骨小梁,肿瘤略呈分叶状,内见有圆形、卵圆形、短梭形瘤细胞呈巢状、索状、网格状、镶嵌状排列,核染色质细致,未见明显核分裂象,有明显纤维黏液样背景的间质.免疫表型:vimentin、S-100蛋白均(+),CK(-).结论 OFT是一种分类尚未确定的罕见肿瘤,属中间型肿瘤.其特征性的骨壳结构、独特的细胞形态及排列方式、免疫表型具有诊断意义. 相似文献
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循证医学在高等医学院校的一些临床教学中已经有了很好的应用,在病理学实验课教学过程中引进循证医学的理念,有利于培养医学生在病理学习中发现问题、寻求证据、分析资料、解决问题等方面的能力,有利于教学质量的提高和学生综合素质的培养. 相似文献
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目的 探讨下颌骨造釉细胞癌临床病理特点和鉴别诊断要点.方法回顾性分析1例下颌骨成釉细胞癌复发病例和文献资料,进行光镜和免疫组化标记观察.结果 镜检可见瘤细胞呈岛状分布,周边细胞呈栅栏状排列,中央呈星网状,细胞具有异型性,可见核分裂象,局部见坏死等.免疫组化标记瘤细胞高分子角蛋白(CKH)、低分子角蛋白(CKL)、p63均阳性,Calretinin阴性,Ki-67增殖指数>40%,该肿瘤应与其他牙源性的恶性肿瘤相鉴别.结论 造釉细胞癌的病理诊断主要依靠组织病理学和肿瘤的生长方式,目前对其报道的病例仍然有限. 相似文献