白花蛇舌草干预湿热瘀滞型肠内多发息肉术后复发的临床研究

目的 临床观察白花蛇舌草干预湿热瘀滞型肠内多发息肉患者内镜治疗术后复发情况。方法 采用前瞻性的随机空白对照试验设计，选取2019年9月1日—2020年12月31日上海中医药大学附属普陀医院消化科收治的门诊及住院结直肠多发息肉患者132例作为研究对象。采用随机方法分为对照组和试验组，每组66例。对照组行内镜治疗术给予常规治疗后无药物干预，试验组在对照基础上给予白花蛇舌草汤剂（每日取白花蛇舌草15 g、大枣3枚，煎取400 mL汤剂，分2次饭后温服）治疗，连续干预1年。观察并比较两组术前与术后1年肠道内息肉的复发率、息肉数目、息肉最大直径、中医证候评分及肝肾功能及血常规的差异。结果 干预1年后，试验组复发9例（14.75%），对照组复发21例（33.33%），两组息肉复发率比较，差异有统计学意义（P＜0.05）。试验组腺瘤、伴重度异型增生、体质量指数（BMI）≥24 kg·m^-2患者治疗后息肉复发率均较对照组同类型降低，差异显著（P＜0.05）；术后1年试验组息肉最大直径及息肉数目均较对照组显著减小，差异显著（P＜0.05）；术后1年试验组中医证候各项评分均显著低于对照组（P＜0.05）；术后1年，两组中医证候疗效比较，差异具有统计学意义（P＜0.05），且术前、术后1年两组患者肝肾功能、凝血功能等安全性指标无显著差异。结论 应用白花蛇舌草干预结直肠息肉术后患者，1年后明显降低肠内息肉的复发率，尤以腺瘤性息肉、重度异型增生、BMI超重患者更显著，不仅改善临床症状，还能有效预防结直肠息肉的复发，改善患者的预后。     

70例晚期肺恶性肿瘤全肺切除术后的疗效分析

198 5年 8月～ 2 0 0 1年 8月我院共进行非小细胞肺癌全肺切除手术 6 9例 ,肺静脉肉瘤全肺切除 1例。现报告如下。1　临床资料1 1　一般资料 :本组男 5 1例 ,女 19例 ,年龄 16～ 71岁 ,平均 5 1岁。左全肺切除 4 9例 ,右全肺切除 2 1例。其中心包内切除 5例 ,有 2例伴部分上腔和右心房切除 ,1例伴部分左房 (包括一侧肺静脉 )切除。3例肺癌肺叶切除术后 ,同侧肺叶复发再行余肺切除。同时行部分胸壁肋骨切除 +胸改手术 3例。1 2　病理 :鳞癌 39例 ,腺癌 2 8例 (其中低分化腺癌5例 ,粘液腺癌 2例 ) ,未分化癌 2例 ,肺静脉内血管平滑肌肉瘤 1例…     

环戊硫酮治疗干眼的临床疗效评价

Objective To investigate anethol trithione therapic efficiency on dry eye. Methods It was a prospective random double-blind controlled study. Eighty cases diagnosed dry eye in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center from 2006 to 2008 were divided into two groups: anethol trithione group and control group, 40 cases in each group. Every group was then divided into two subgroups: weak dry eye subgroup, middle and severe dry eye subgroup. All groups had been added with 0.05% refresh drops. All patients had been detected and evaluated by subjective symptoms of dry eye, visual acuity,corneal fluorescent staining(F1), break-up time(BUT) and Schirmer Ⅰ test (SⅠT) at pre-therapy and 3,7,28 d of post-therapy. All groups had been compared and analyzed by F test and sample mean difference (SMD) or median difference (MD) comparison between pre-therapy and post-therapy. Results Except of tear and red eye, the other subjective symptoms of dry eye, F1, BUT and SⅠT of weak dry eye subgroup of both groups had been improved at 7 d after therapy. Only those of middle and severe dry eye subgroup of anethol trithione group had been improved at 7 d after therapy compared with those of pre-therapy: SMD=0.96 (visual tiredness), 1.26 (dry and unsmooth sensation), 0.82 (foreign body sensation), 1.28 (burning sensation), 1.05 (photophobia), 1.48 ( pain ) ; MD=0.30 (visual acuity), 4.00 (F1) ,5.00 (BUT), 5.00 (SⅠT) [F=15.30 (visual tiredness), 15.68 (dry and unsmooth sensation ), 13.56 (foreign body sensation), 20. 91 ( burning sensation ), 18.90 (photophobia), 27.22 ( pain ), 10.54 (visual acuity), 188.21 (F1) ,261.76 (BUT) ,269.05 (SⅠT) ;P<0. 05]. Those of middle and severe dry eye subgroup of control group hadn't significantly been improved at 28 d after therapy: SMD=0.10 (visual tiredness) ,0.16 (dry and unsmooth sensation) ,0.09 (foreign body sensation) ,0.38 ( burning sensation ), 0.24(photophobia) ,0.36 (pain) ,0.23 (red eye) ; MD=0.10 (visual acuity) ,0.50(F1) ,0.50(BUT), 0.50(SⅠT) [F=1.76 (visual tiredness), 1.61 (dry and unsmooth sensation), 1.02 (foreign body sensation),2.39 (burning sensation), 2.42 (photophobia), 2.73 ( pain ), 2.55 ( red eye ), 1.46 ( visual acuity) ,2.35 (F1) ,2.90 (BUT) ,2.76 (SⅠT) ; P>0.05]. SⅠT of anethol trithione group had been improved more significantly after therapy (F=13.77, P<0.05). Conclusion Anethol trithione could significantly improve middle and severe dry eye patients' symptoms and signs whose lacrimal gland function survival and it has clinical application value.     

环戊硫酮治疗干眼的临床疗效评价

Objective To investigate anethol trithione therapic efficiency on dry eye. Methods It was a prospective random double-blind controlled study. Eighty cases diagnosed dry eye in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center from 2006 to 2008 were divided into two groups: anethol trithione group and control group, 40 cases in each group. Every group was then divided into two subgroups: weak dry eye subgroup, middle and severe dry eye subgroup. All groups had been added with 0.05% refresh drops. All patients had been detected and evaluated by subjective symptoms of dry eye, visual acuity,corneal fluorescent staining(F1), break-up time(BUT) and Schirmer Ⅰ test (SⅠT) at pre-therapy and 3,7,28 d of post-therapy. All groups had been compared and analyzed by F test and sample mean difference (SMD) or median difference (MD) comparison between pre-therapy and post-therapy. Results Except of tear and red eye, the other subjective symptoms of dry eye, F1, BUT and SⅠT of weak dry eye subgroup of both groups had been improved at 7 d after therapy. Only those of middle and severe dry eye subgroup of anethol trithione group had been improved at 7 d after therapy compared with those of pre-therapy: SMD=0.96 (visual tiredness), 1.26 (dry and unsmooth sensation), 0.82 (foreign body sensation), 1.28 (burning sensation), 1.05 (photophobia), 1.48 ( pain ) ; MD=0.30 (visual acuity), 4.00 (F1) ,5.00 (BUT), 5.00 (SⅠT) [F=15.30 (visual tiredness), 15.68 (dry and unsmooth sensation ), 13.56 (foreign body sensation), 20. 91 ( burning sensation ), 18.90 (photophobia), 27.22 ( pain ), 10.54 (visual acuity), 188.21 (F1) ,261.76 (BUT) ,269.05 (SⅠT) ;P<0. 05]. Those of middle and severe dry eye subgroup of control group hadn't significantly been improved at 28 d after therapy: SMD=0.10 (visual tiredness) ,0.16 (dry and unsmooth sensation) ,0.09 (foreign body sensation) ,0.38 ( burning sensation ), 0.24(photophobia) ,0.36 (pain) ,0.23 (red eye) ; MD=0.10 (visual acuity) ,0.50(F1) ,0.50(BUT), 0.50(SⅠT) [F=1.76 (visual tiredness), 1.61 (dry and unsmooth sensation), 1.02 (foreign body sensation),2.39 (burning sensation), 2.42 (photophobia), 2.73 ( pain ), 2.55 ( red eye ), 1.46 ( visual acuity) ,2.35 (F1) ,2.90 (BUT) ,2.76 (SⅠT) ; P>0.05]. SⅠT of anethol trithione group had been improved more significantly after therapy (F=13.77, P<0.05). Conclusion Anethol trithione could significantly improve middle and severe dry eye patients' symptoms and signs whose lacrimal gland function survival and it has clinical application value.     

主动脉窦瘤破裂18例的诊断和外科治疗

１９８０年６月至１９９１年１１月，我院共手术治疗主动脉窦瘤破裂１８例。主要靠休征、Ｂ型超声心动图、彩色多普勒和升主动脉造影确诊。全部在体外循环浅度～中度低温条件下进行手术，死亡２例，其余康复，本文对诊断和手术问题进行讨论。     

围心内直视手术期自体输血的安全性及效果（附42例报告）

对４２例心内直视手术患者采用术前采集自体血１￣２次（１０ｍｌ·ｋｇ＾－１／次），结合术中血液稀释（麻醉后按１５ｍｌ／ｋｇ采自体血），机器预冲液中一次性加入抑肽酶４万μ／ｋｇ等综合措施，可使整个围手术期完全不输异体血，只输自体血。脑血氧饱和度和脉搏血氧饱和度转机中与麻醉前比无统计学意义（Ｐ〉０．０５）。用连续４２例输异体血者作对照，自体输血组２４小时和总的纵隔心包引流量分别减少４７．４８％和４６．８     

工业空调工作场所化学毒物与防控调查研究

[目的]了解工业空调工作场所化学毒物接触与防护状况,为探讨其防控措施提供依据。[方法]对35家工业空调工作场所进行职业卫生调查监测。[结果]35家工业空调工作场所生产过程使用铅、苯系物、正己烷、三氯乙烯、丙酮和异丙醇等化学物质,涉及企业主要在电子、印刷、工艺品和制药等行业,接触工种主要是锡焊、印刷、粘合、清洗和涂漆等,化学毒物接触人数占空调工作场所工人数的11.3%,个人防护用品使用率仅15.5%。有48%室内新风补充量不足,14.9%检测点超标以及局部通风排气效果欠佳。[结论]化学毒物对工业空调工作场所的影响不可忽视,做好通风排毒设施的设计、安装和定期维护管理,是预防与控制化学毒物危害重要的措施。     

全层外翻连续缝合在胃-食管吻合术中的应用

目的：探讨食管癌、贲门癌切除后胃－食管吻合的缝合技术，方法：食管癌切除后，用带无损伤缝针4－0可吸收vicryl线行胃－食管前，后壁全层外翻连续缝合吻合26例，结果：26例病人全部康复出院，无吻合口瘘和狭窄的发生。结论：（1）前、后壁全层外连续缝合吻合口腔外黏膜及肌层的和长愈合处于一个无酸无酶的环境，有利于吻合口的愈合，防止了术后吻合口瘘的发生；（2）全层外翻缝合使吻合口腔内黏膜对合平整，光滑，呆吸收线缝合减轻和缩短了缝线反应，慢性炎症反应，纤维增生及瘢痕的形成，防止了吻合口狭窄的发生；（3）连续缝合缩短了吻合时间。     

左腋窝小切口经胸膜外治疗动脉导管未闭10例

我院自 2 0 0 0年 6月至 2 0 0 1年 10月采用左腋窝小切口经胸膜外结扎动脉导管未闭 10例 ,现报道如下。1　临床资料1.1　一般资料 :女性 10例 ,年龄 2～ 11岁 ,平均 6 .0岁 ,体重 11～ 2 6 kg,平均 15 .8kg;动脉导管均为管型 ,直径 0 .6～1.6 cm,平均 1.0 cm。1.2　手术方法 :病人右侧卧位 ,左上肢屈曲悬吊于头部架上以显露腋窝 ;在腋窝内取纵切口 4～ 5 cm ,切开皮肤后电刀分离皮下组织至胸壁 ,将切口向下牵拉 ,电刀小心切开第三肋间肌后剥离胸膜 ,使用婴幼儿张胸器张胸后剥离胸膜的同时向两侧扩切肋间肌 ,充分利用有限的皮肤切口张胸到最…     

晶状体膜蛋白MIP基因C末端一个新的错义突变导致双眼多形性先天性白内障

目的 定位一个双眼多形性先天性白内障家系的致病位点,寻找疾病家系的致病基因.方法 应用ABI-MD10试剂盒中的常染色体382个微卫星位点,对一个常染色体显性、双眼具有不同白内障形态的先天性白内障家系进行全基因组扫描.MLINK软件进行两点连锁分析.直接测序候选基因外显子.结果 在D12S83处获得最大LOD值Zmax=5.44(θ=0),该家系致病位点被定位到12p11.2-q15之间的区域上,在该区域的白内障候选基因晶状体膜蛋白基因(major intrinsic protein,MIP)的第4外显子中发现单个碱基错义突变,702ntG→A,导致p.R233K.结论 该先天性白内障由MIP基因702ntG→A突变所致,导致MIP蛋白质的C-末端中p.R233K,从而可能减少了氢键的形成,影响了该蛋白C-末端的稳定性,推测影响了MIP对水的调节及由该蛋白质形成的细胞之间的连接.这一新突变为目前世界上首次报道.