全文获取类型
收费全文 | 517篇 |
免费 | 23篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 21篇 |
妇产科学 | 4篇 |
基础医学 | 77篇 |
口腔科学 | 22篇 |
临床医学 | 30篇 |
内科学 | 112篇 |
皮肤病学 | 9篇 |
神经病学 | 44篇 |
特种医学 | 8篇 |
外科学 | 106篇 |
综合类 | 4篇 |
预防医学 | 12篇 |
眼科学 | 7篇 |
药学 | 38篇 |
肿瘤学 | 38篇 |
出版年
2023年 | 6篇 |
2022年 | 13篇 |
2021年 | 19篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 17篇 |
2017年 | 16篇 |
2016年 | 14篇 |
2015年 | 18篇 |
2014年 | 17篇 |
2013年 | 28篇 |
2012年 | 40篇 |
2011年 | 31篇 |
2010年 | 24篇 |
2009年 | 16篇 |
2008年 | 40篇 |
2007年 | 31篇 |
2006年 | 37篇 |
2005年 | 38篇 |
2004年 | 25篇 |
2003年 | 24篇 |
2002年 | 22篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 2篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有540条查询结果,搜索用时 15 毫秒
1.
Satsuki Sumitani Shu-Ichi Ueno Yasuhito Ishimoto Takahide Taniguchi Masahito Tomotake Ikuyo Motoki Ken Yamauchi Tetsuro Ohmori 《Seishin shinkeigaku zasshi》2006,108(12):1282-1292
BACKGROUND: Although selective serotonin reuptake inhibitors (SSRIs) are the mainstay of pharmacological treatment for obsessive-compulsive disorder (OCD), some OCD patients do not show improvement. Sometimes, the addition of a low-dose atypical antipsychotic, such as risperidone, or olanzapine, to ongoing SSRI treatment has been shown to be effective. However, there are patients who still show no response after trials with this augmentation therapy. In the present study, we examined the clinical features of OCD patients who showed different responses to pharmacological treatment. SUBJECTS AND METHOD: Fifty OCD patients were divided into three groups according to their pharmacological responses: responders to SSRI (group A: n= 25), responders to SSRI with an atypical antipsychotic (group B: n= 15), and non-responders to both SSRI and SSRI with an atypical antipsychotic (group C: n= 10). We examined the clinical features such as age, sex, age of onset, duration of illness, types of obsessive-compulsive symptoms, severity, improvement after treatment, insight into disease, depression, comorbidity, involving family members in compulsive or ritualistic behavior, and the level of social adaptation of each OCD group. RESULTS: Twenty five patients showed a good response to SSRI monotherapy, 15 showed a response to antipsychotic augmentation, and 10 were non-responders to both SSRI and SSRI with an atypical antipsychotic. Significantly lower insight levels were observed only in group B and higher depressive levels in group C. OCD patients who were refractory to SSRI monotherapy showed comorbidity at a significantly higher frequency. OCD patients in group A showed significantly greater improvement, and group B showed inferior social adaptation after treatment. There were no significant differences in age, sex, age of onset, duration of illness, severity, involving family members in compulsive or ritualistic behavior, and social adaptation before treatment in the three OCD groups. CONCLUSION: There were differences in the clinical features of OCD patients who showed different responses to pharmacological treatment. Our results suggest that OCD is clinically and biologically heterogeneous. It may be important to divide OCD patients into subgroups for future studies. 相似文献
2.
Junya Katoh Shunya Shindo Satsuki Kina Seiichiro Katahira Hiroshi Osawa Masahiro Kobayashi Osamu Suzuki Kihachiro Kamiya Yusuke Tada 《Surgery today》1995,25(6):554-556
Aneurysmal rupture into the intestinal tract is a rare but disastrous complication of an internal iliac artery aneurysm. We report herein the successful surgical repair of a fistula between a huge aneurysm of the right internal iliac artery and the rectum in an 81-year-old man. After a femoro-femoral cross-over bypass had been performed, the aneurysm was opened and its patent arterial branches were ligated with sutures. The fistula was then intra-aneurysmally sutured and covered with an omental flap. The diagnostic and therapeutic approaches to this severe complication are discussed with a review of the literature following the presentation of this case. 相似文献
3.
In order to examine temporal changes in enhancement of transmitter release during long-term potentiation (LTP), we examined amplitude fluctuation of excitatory postsynaptic potentials (EPSPs) for longer periods than 2 h after tetanic stimulation (up to 4 h in the longest observation). The relative magnitude of excitatory postsynaptic potentiation (EPSP) fluctuation (coefficient of variation, CV) reduced throughout the observation periods in association with an increase in EPSP amplitude after tetanic stimulation. The reciprocals of squared CVs (= mean2/variance) were almost in proportion to the magnitude of LTP, and the ratio of 1/CV2 and the LTP magnitude did not change significantly for up to 4 h. These findings suggest that a prolonged enhancement of transmitter release from presynaptic terminals underlies LTP, and the relative contribution of this presynaptic enhancement does not change significantly for 2 h (maybe up to 4 h, or longer) after tetanic stimulation. 相似文献
4.
Takuya Sekiguchi Yoshihiro Hagiwara Akira Ando Kenji Kanazawa Kazuaki Suzuki Masashi Koide Yutaka Yabe Satsuki Onoda Eiji Itoi 《Journal of orthopaedic science》2021,26(4):595-598
BackgroundThe Shoulder Pain and Disability Index (SPADI) is a simple disease specific questionnaire that is used to evaluate the impact of shoulder disorders. The purpose of this study was to translate the SPADI into Japanese (SPADI-Jp) and evaluate its reliability and validity in Japanese patients with shoulder disorders.MethodsCross-cultural adaptation of the SPADI was performed according to international guidelines. A total of 100 patients with shoulder disorders participated in this study. Each participant was asked to finish the SPADI-Jp, Disability of Arm, Shoulder and Hand (DASH), and the Short-Form 36 (SF-36) at the initial visit. Thirty-four patients repeated the SPADI-Jp to assess the test–retest reliability. The test–retest reliability was quantified using the interclass correlation coefficient (ICC), while Cronbach's alpha was calculated to assess the internal consistency. The construct validity was assessed using Spearman's rank correlation coefficients.ResultsInternal consistency in the SPADI-Jp was very high (0.969), as measured by the Cronbach's alpha. The ICC of the SPADI-Jp was 0.930. There was a strong, positive correlation between the DASH and the SPADI-Jp (r = 0.837, p < 0.001). The SPADI-Jp was significantly correlated with most of the SF-36 subscales. The correlations of the SPADI-Jp with physical subscales of the SF-36 were stronger than those with the other subscales.ConclusionsWe demonstrated that the SPADI-Jp is a reliable and valid self-assessment tool. Because cross-cultural adaptation, validation, and reliability of the disease-specific questionnaire for shoulder pain and disability have not been evaluated in Japan, the SPADI-Jp can be useful for evaluating such patients in the Japanese population. 相似文献
5.
Video‐assisted thoracoscopic surgery can help enable the complete resection of a mediastinal tumor caused by immunoglobulin G4‐related disease and avoid the need for postoperative medication: A case report 下载免费PDF全文
Tsuyoshi Uchida Hirochika Matsubara Satoshi Nagasaka Satsuki Kina Tomofumi Ichihara Hiroyasu Matsuoka Hiroyuki Nakajima 《Asian journal of endoscopic surgery》2018,11(3):248-251
Immunoglobulin (Ig) G4‐related disease has various clinical signs and symptoms, and steroidal therapy with corticosteroids has been found to be effective for treatment. Few cases of IgG4‐related disease associated with paravertebral tumor have been reported, and there have been no reports on complete resection of such a tumor. Here, we report a case of IgG4‐related disease associated with a paravertebral tumor that was successfully resected without the need for postoperative medication. An 84‐year‐old woman was admitted to our hospital with a paravertebral tumor. She underwent thoracoscopic surgery, and pathological examination of the tumor specimen revealed that the tumor resulted from IgG4‐related disease. After resection, there was no need for postoperative medication. Our case indicates the rare possibility of a paravertebral tumor associated with IgG4‐related disease and the potential for complete resection as a treatment for such a tumor. 相似文献
6.
7.
8.
Sujino Yasumori Kuroda Kensuke Yoshitake Koichi Yagi Nobuichiro Anegawa Eiji Mochizuki Hiroki Iwasaki Keiichiro Nakajima Seiko Watanabe Takuya Yanase Masanobu Fukushima Satsuki Fujita Tomoyuki Kobayashi Junjiro Fukushima Norihide 《Journal of artificial organs》2021,24(2):265-268
Journal of Artificial Organs - Aortic insufficiency (AI) is an important adverse event in patients with continuous-flow (CF) left ventricular assist device (LVAD) support. AI is often progressive,... 相似文献
9.
Daisuke Yoshioka Koichi Toda Taichi Sakaguchi Shigeru Miyagawa Hiroyuki Nishi Yasushi Yoshikawa Satsuki Fukushima Shunsuke Saito Tetsuya Saito Ikuko Shibasaki Yasushi Sakata Tomohito Ohtani Yoshiki Sawa 《Journal of artificial organs》2013,16(3):386-388
Continuous-flow left ventricular assist devices (LVADs) provide acceptable clinical results, but the long waiting period for heart transplantation leads to diverse complications. LVAD support can cause reverse left ventricular (LV) remodeling that results in the improvement of LV function and allows LVAD removal. We present a case of successful removal of a DuraHeart LVAD because of sufficient recovery of LV function. Before LVAD removal, we conducted an “LVAD weaning test” by decreasing pump speed and performing an additional normal saline infusion test. We consider that the LVAD weaning test can be used in place of the “pulsatile LVAD off test.” 相似文献