全文获取类型
收费全文 | 189篇 |
免费 | 3篇 |
国内免费 | 4篇 |
专业分类
儿科学 | 3篇 |
妇产科学 | 3篇 |
基础医学 | 20篇 |
口腔科学 | 2篇 |
临床医学 | 20篇 |
内科学 | 70篇 |
皮肤病学 | 3篇 |
神经病学 | 10篇 |
外科学 | 19篇 |
综合类 | 6篇 |
预防医学 | 7篇 |
眼科学 | 2篇 |
药学 | 26篇 |
中国医学 | 1篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 2篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2016年 | 2篇 |
2015年 | 1篇 |
2014年 | 3篇 |
2013年 | 2篇 |
2012年 | 4篇 |
2011年 | 1篇 |
2010年 | 14篇 |
2009年 | 18篇 |
2008年 | 7篇 |
2007年 | 7篇 |
2006年 | 7篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 6篇 |
1998年 | 4篇 |
1997年 | 12篇 |
1996年 | 15篇 |
1995年 | 5篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1978年 | 1篇 |
1966年 | 2篇 |
1965年 | 3篇 |
1964年 | 5篇 |
1963年 | 2篇 |
1962年 | 1篇 |
1960年 | 1篇 |
1958年 | 6篇 |
1957年 | 2篇 |
1956年 | 3篇 |
1955年 | 1篇 |
排序方式: 共有196条查询结果,搜索用时 31 毫秒
1.
2.
H-C. HSIA H-C. LIN F-Y. LEE Y-T. TSAI S-D. LEE H-C. MENG Y. CHAO S-S. WANG K-J. LO 《Journal of gastroenterology and hepatology》1993,8(1):15-20
Abstract Somatostatin has been used to effectively control acute variceal haemorrhage, with conjectured mechanisms on portal hypertension. We, therefore, evaluated the effects of somatostatin on hepatic and systemic haemodynamics in 15 patients with hepatitis B-related cirrhosis and portal hypertension. All patients received an intravenous, continuous infusion of somatostatin 250 μg/h, following a bolus injection of 250 μg. In systemic haemodynamics, the mean arterial pressure (MAP) increased ( P < 0.05), associated with a reflex bradycardia within 3 min following bolus injections, compared with basal values. The right atrial pressure, pulmonary capillary wedge pressure, inferior vena cava pressure, cardiac index, and systemic vascular resistance remained unaffected after drug infusion. In hepatic haemodynamics, the wedge hepatic vein pressure remained unchanged after drug administration. However, there was an increase in free hepatic vein pressure (FHVP; P < 0.05), and a trend toward a decrease in the hepatic vein pressure gradient (HVPG; P = 0.063), within 3 min after bolus injection. Furthermore, the hepatic blood flow decreased significantly at 10 and 30 min after somatostatin infusion ( P < 0.05). The effective sinusoidal perfusion assessed by indocyanine green infusion also decreased progressively at 10 min ( P = 0.057) and 30 min ( P < 0.05). We concluded that somatostatin, at the dose used in this study, caused a transient and bolus-related vasoconstrictive effect, resulting in increases in MAP and FHVP, a decrease in heart rate, and a trend toward lower HVPG. In addition, somatostatin reduced the hepatic blood flow and effective sinusoidal perfusion which may be hazardous to cirrhotic patients during variceal haemorrhage. 相似文献
3.
4.
Purpose: The purpose was to compare the outcomes betweenday-5 blastocyst and day-2 embryo transfers.
Methods: Infertile women who accepted the ovarian hyperstimulationand oocyte retrieval were divided: Group 1, day2 embryo transfer, group 2, cultured to day 5 in serum-freesequential culture medium and transfer. Early embryoquality and growth, blastocyst formation and quality,implantation rate (IR) and pregnancy rates (PR) weredetected.
Results: Total blastocyst formation rate was 49.4%. Betterearly embryo quality (days 2, 3) and higher day 3 blastomerenumber possess higher blastocyst formation rate. The IR forday 2 and day 5 embryos were 10.8% and 22.2%, respectively.The PR in both groups were comparable (37.3% vs. 41.8%).
Conclusions: Blastocyst transfer has higher IR and comparablePR as those of day 2 embryo transfer. Early embryoqualities and day 3 blastomere number are useful in predictingthe final blastocyst formation. Blastocyst formationrate is not related to maternal age, infertile causes, inseminationmethods, and early embryo number. 相似文献
5.
WEN-JEH LIN FA-YAUH LEE HAN-CHIEH LIN YANG-TE TSAI SHOU-DONG LEE KWOK-HUNG LAI HSIAO-CHUNG HSIA SUN-SANG WANG KWANG-JUEI LO 《Journal of gastroenterology and hepatology》1991,6(2):145-149
Gastric mucosal lesions are common in patients with cirrhosis. Among them, snake skin pattern gastropathy (SSPG) is the most distinguishing one. A prospective study was conducted to investigate the incidence of SSPG in cirrhotic patients, the relationship between the degree of portal pressure and SSPG, and the possible association of SSPG with serum levels of gastrin and pepsinogen I. SSPG was found to be significantly more common in 100 cirrhotic patients than in 100 age- and sex-matched healthy controls (41% vs 0%, P less than 0.0001). Hepatic venous pressure gradient and serum gastrin and pepsinogen I levels were measured in 21 cirrhotic patients with SSPG and 25 cirrhotics without SSPG. There was no significant difference in hepatic venous pressure gradient (16.1 +/- 4.4 mmHg vs 16.1 +/- 4.9 mmHg, P greater than 0.05), serum gastrin level (78.0 +/- 26.7 pg/mL vs 80.1 +/- 32.5 pg/mL, P greater than 0.05) and serum pepsinogen I level (69.5 +/- 26.6 ng/mL vs 65.2 +/- 26.1 ng/mL, P greater than 0.05) in cirrhotic patients with or without SSPG. In conclusion, SSPG is common in cirrhotic patients. Portal pressure per se may not be the only factor causing SSPG--other aggressive factors may be needed together to cause the gastropathy. There is no evidence of correlation between serum gastrin or pepsinogen I level and SSPG. 相似文献
6.
P.‐Y. LIU C.‐C. LIN W.‐C. TSAI Y.‐H. LI L.‐J. LIN G.‐Y. SHI J.‐S. HONG J.‐H. CHEN H.‐L. WU 《Journal of thrombosis and haemostasis》2008,6(10):1685-1692
Summary. Background: Dextromethorphan (DM) is reported to reduce the inflammation‐mediated degeneration of dopaminergic neurons. Objective: The goal of this study was to test if DM can improve the endothelial dysfunction and inflammatory markers in heavy smokers. Patients and methods: Forty habitual smoking healthy male volunteers (mean age, 31.5 ± 1.4 years) were randomly given either DM (120 mg day?1) or a placebo for 6 months. We determined endothelial function using the brachial artery diameter changes in flow‐mediated dilatation (FMD) and measured their inflammatory and oxidative markers. A sex‐and‐age matched non‐smoking group (n = 20) was compared as normal parameters. Results: Habitual smokers showed impaired baseline endothelial function in FMD (smoking vs. non‐smoking: 6.3 ± 1.8 vs. 10.2 ± 2.3% respectively, P < 0.01). Without change in smoking behavior, lipid and metabolic parameters, a significant increase in FMD was found in the DM‐treated group (32%), accompanied by a decrease in high‐sensitivity C‐reactive protein (hs‐CRP), phospholipase A2, matrix metalloproteinase‐3, interleukin 6 (IL‐6) and tumor necrosis factor‐α receptor II (TNF‐α RII) (all P < 0.05), but unchanged in von Willebrand factor (VWF)and plasminogen activator inhibitor‐1 (PAI‐1). An increase in plasma glutathione peroxidase and a decrease in spot urinary excretion of 8‐epi‐prostaglandin F2a were found in DM‐treated smokers. Conclusions: Our study suggests that a 6‐month treatment with DM can improve endothelial function and attenuate vascular oxidative stress and inflammation markers in habitual smokers. 相似文献
7.
LI-KAI LO M.D. TSENG-FANG TSAI M.D. † YU-FU CHEN M.D. CHI-MING HUNG M.D. WANG-CHENG KO M.D. 《Pediatric dermatology》2009,26(1):111-112
Abstract: Connective tissue nevi of collagen type are now classified in four major subtypes. In addition to the clinicopathological features of papulolinear collagenoma, which is considered as a variant of isolated collagen harmatoma, the case we present has a unique arborizing pattern. 相似文献
8.
BACKGROUND: Cyn d 1, the major allergen of Bermuda grass pollen, consists of a number of isoforms. OBJECTIVE: To examine the extent of sequence variation of Cyn d 1 isoforms at the molecular level. METHODS: A Bermuda grass pollen lambdaZAP II cDNA expression library was immunoscreened with anti-Cyn d 1 monoclonal antibodies. The reactive clones were isolated, subcloned into Escherichia coli, and sequenced. Some of them were expressed in the yeast Pichia pastoris to obtain recombinant Cyn d 1 proteins. RESULTS: Ten cDNA clones were obtained, all these clones encode the full length of Cyn d 1 protein. Their deduced mature proteins can be grouped into: the long ones with 246 amino acids, and the short ones with 244 amino acids. The last two amino acids (AG) of the long Cyn d 1 are deleted in the short Cyn d 1. The remaining amino acid sequences share more than 98% identity; a total of nine amino acid variations were observed. Two recombinant Cyn d 1 proteins (rCyn d 3-2 and rCyn d 5-4) with three amino acid substitutions showed differential IgE-binding profiles. CONCLUSION: The present study extended our understanding of the primary structure of isoforms of Cyn d 1. 相似文献
9.
LI‐WEI LO M.D. SATOSHI HIGA M.D. Ph.D. YENN‐JIANG LIN M.D. SHIH‐LIN CHANG M.D. TA‐CHUAN TUAN M.D. YU‐FENG HU M.D. WEN‐CHIN TSAI M.D. HSUAN‐MING TSAO M.D. CHING‐TAI TAI M.D. SUGAKO ISHIGAKI M.D. ASUKA OYAKAWA M.D. MINETAKA MAEDA M.D. KAZUYOSHI SUENARI M.D. SHIH‐ANN CHEN M.D. 《Journal of cardiovascular electrophysiology》2010,21(6):640-648
Unipolar Characteristics of CFAEs. Background: The noncontact mapping (NCM) system possesses the merit of global endocardial recording for unipolar and activation mapping. Objective: We aimed to evaluate the unipolar electrogram characteristics and activation pattern over the bipolar complex fractionated atrial electrogram (CFAE) sites during atrial fibrillation (AF). Methods: Twenty patients (age 55 ± 11 years old, 15 males) who underwent NCM and ablation of AF (paroxysmal/persistent = 13/7) were included. Both contact bipolar (32–300 Hz) and NCM virtual unipolar electrograms (0.5–300 Hz) were simultaneously recorded along with the activation pattern (total 223 sites, 11 ± 4 sites/patient). A CFAE was defined as a mean bipolar cycle length of ≤ 120 ms with an intervening isoelectric interval of more than 50 ms (Group 1A, n = 63, rapid repetitive CFAEs) or continuous fractionated activity (Group 1B, n = 59, continuous fractionated CFAEs), measured over a 7.2‐second duration. Group 2 consisted of those with a bipolar cycle length of more than 120 ms (n = 101). Results: The Group 1A CFAE sites exhibited a shorter unipolar electrogram cycle length (129 ± 11 vs 164 ± 20 ms, P < 0.001), and higher percentage of an S‐wave predominant pattern (QS or rS wave, 63 ± 13% vs 35 ± 13%, P < 0.001) than the Group 2 non‐CFAE sites. There was a linear correlation between the bipolar and unipolar cycle lengths (P < 0.001, R = 0.87). Most of the Group 1A CFAEs were located over arrhythmogenic pulmonary vein ostia or nonpulmonary vein ectopy with repetitive activations from those ectopies (62%) or the pivot points of the turning wavefronts (21%), whereas the Group 1B CFAEs exhibited a passive activation (44%) or slow conduction (31%). Conclusions: The bipolar repetitive and continuous fractionated CFAEs represented different activation patterns. The former was associated with an S wave predominant unipolar morphology which may represent an important focus for maintaining AF. (J Cardiovasc Electrophysiol, Vol. 21, pp. 640‐648, June 2010) 相似文献
10.
Modern use of Chinese herbal formulae from Shang-Han Lun 总被引:2,自引:0,他引:2
CHEN Fang-pey CHEN Fun-jou JONG Maw-shiou TSAI Hui-lin WANG Jen-ren HWANG Shinn-jang 《中华医学杂志(英文版)》2009,122(16):1889-1894