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JIN-SONG HE SATOSHI HORIKOSHI KAZUHIKO FUNABIKI ISAO SHIRATO YASUHIKO TOMINO 《Nephrology (Carlton, Vic.)》2002,7(2):83-86
SUMMARY: Inhibition of mevalonate synthesis by several statins has been shown to suppress DNA synthesis in glomerular mesangial cells. In the present study, we investigated the effect of a new statin, cerivastatin, on fetal calf serum (FCS)-induced DNA synthesis of cultured rat mesangial cells. Cultured rat mesangial cells were stimulated by 10% FCS in the presence or absence of cerivastatin and mevalonate. 5-bromo-2-deoxyuridine (BrdU) incorporation was used to assess DNA synthesis. the present study showed that 10% FCS caused marked stimulation of DNA synthesis in the mesangial cells. Cerivastatin inhibited FCS-stimulated BrdU incorporation in a dose-dependent manner. IC50 was approximately 1 umol/L. Exogenous mevalonate, farnesyl pyrophosphate and geranylgeranyl pyrophosphate significantly prevented the inhibitory effect of cerivastatin on DNA replication. It appears that cerivastatin, by inhibiting the synthesis of mevalonate, may suppress DNA synthesis in the mesangial cells. 相似文献
3.
TOMOHITO GOHDA MITSUO TANIMOTO KAORI WATANABE-YAMADA MASAKAZU MATSUMOTO SHIGERU KANEKO SHINJI HAGIWARA KENJI SHIINA TOSHIHIDE SHIKE KAZUHIKO FUNABIKI YASUHIKO TOMINO 《Nephrology (Carlton, Vic.)》2005,10(S2):S22-S25
SUMMARY: Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) in Japan, Western Europe, and the United States. Mega studies such as Diabetes Control and Complication Trial (DCCT), Epidemiology of Diabetes Interventions and Complications (EDIC), and the United Kingdom Prospective Diabetes Study (UKPDS) clarified that poor glycemic and blood pressure control are undoubtedly involved in the development of nephropathy. However, these factors are not sufficient to predict which diabetic patients will develop renal disease, because not all patients with poor glycemic and blood pressure control develop renal disease. Since ethnic variations and familial clustering of diabetic nephropathy have been observed, genetic factors might contribute to susceptibility to this disease. Several methods such as (genome wide) association studies, sib-pair analysis, and quantitative trait loci (QTLs) analysis are available to examine polygenic diseases. However, no mutations that could explain the majority of nephropathy cases have been identified so far. The development of most diabetic nephropathy might be explained by the polygenic effect (i.e. many minor gene-gene interactions might be very important in the development of nephropathy). Identification of candidate genes of nephropathy enables targeting of therapy in patients at risk and development of novel therapeutic agents. 相似文献
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IWAHASHI KAZUHIKO; NAKAMURA KAZUHIKO; SUWAKI HIROSHI; MATSUO YOSHINORI; ICHIKAWA YOSHIYUKI 《Alcohol and alcoholism (Oxford, Oxfordshire)》1994,29(6):639-642
In 45 healthy Japanese volunteers, it was found that personsheterozygous for ALDH2 (ALDH2*1/ALDH2*2), and also either heterozygousor mutant homozygous for CYP2E1 (C2/C2 or C1/C2 can drink muchmore alcohol, even with (slight) flushing, than persons heterozygousfor ALDH2 (ALDH2*1/ALDH2*2) and normal homozygous for CYP2E1(C1/C1) 相似文献
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YUKIHIRO HASEGAWA YOSHIHARU KIKAWA JUNKO MIYAMAOTO SHUJI SUGIMOTO MASANORI ADACHI TOSHIHIRO OHURA MITSUFUMI MAYUMI 《Pediatrics international》2003,45(1):5-9
BACKGROUND: In Asian countries, glycerol solution that contains fructose (5%) is often used for management of brain edema. However, glycerol and fructose may cause severe hypoglycemia and metabolic acidosis in patients with fructose-1,6-bisphosphatase (FBPase) deficiency, even under stable conditions. The aim of the present study was to determine whether glycerol solution was used for brain edema during acute metabolic decompensation of hypoglycemia and metabolic acidosis in patients with unrecognized FBPase deficiency in Japan and to examine a long-term prognosis of the patients who had this kind of severe metabolic decompensation with or without glycerol therapy. METHODS: A retrospective study of 20 children with FBPase deficiency was conducted, based on their medical records. RESULTS: Six of the 20 children were given glycerol solution for the presence or possibility of brain edema during acute metabolic decompensation of hypoglycemia and metabolic acidosis; two of the six patients administered with glycerol were given dialysis. In four patients treated with glycerol alone without dialysis, two had no brain edema before glycerol administration but it developed later after the administration. These four patients treated with glycerol alone died or developed severe neurological complications. Fourteen patients who were not treated with glycerol solution had no brain edema and showed good prognosis. CONCLUSIONS: Glycerol solution, which contains fructose in Asian countries including Japan, should not be used as an osmotic agent for treatment of brain edema in patients who have hypoglycemia and retention-type metabolic acidosis, until FBPase deficiency is ruled out by measuring blood concentration of lactate. 相似文献
6.
YOSHIKI NISHIZAWA TAKEHISA FUJITA KAZUHIKO MATSUOKA HIROFUMI NAKAGAWA 《Pediatrics international》2006,48(5):484-488
BACKGROUND: Local force distribution supporting the bodyweight of infants with Down syndrome (DS) appears to be different from that of healthy controls. The purpose of the present study was to establish methods to assess this force distribution and to allow therapeutic evaluation of neurological development in DS infants prior to walking. METHODS: Contact pressure distribution patterns in supine and prone positions were measured by photoelastic methods and were compared between DS infants and healthy controls. The DS group included eight subjects, seven with regular trisomy 21, and one with a Robertson translocation. The controls consisted of 14 neonates, four 4-month-old infants and eight 7-month-old infants. RESULTS: In both groups, head loading ratio decreased as age advanced but the decrement was less in the test group than in the control group. When the bodyweight loading ratios were measured in two different lying positions, that is, prone and supine, the ratios for prone generally tended to be smaller than those for supine in the controls. This kind of difference between prone and supine was not seen in the DS group. The bodyweight is somewhat sustained with limbs and the limbs loading ratios in the DS group were always significantly lower than in the controls. CONCLUSION: Coordinated development of weight-supporting limbs seems to be poor in the DS group. 相似文献
7.
T. SUGIMOTO S. FURUTA H. KAWAMATA M. SUZUKI H. SANO T. ITO 《Xenobiotica; the fate of foreign compounds in biological systems》2013,43(4):425-433
1. The plasma level of Z-300 reached a maximum (Cmax) at 30?min after the oral administration of Z-300 to dog, and disappeared from the systemic circulation with a halflife of 8-9 h. The bioavailability of Z-300 was 52% after the oral administration of Z-300, 3?mg/kg. At doses ranging from 3 to 30?mg/kg, Cmax and AUC (area under the plasma concentration-time curve) were proportional to the dose. 2. The plasma level of Z-300 reached Cmax at 10?min after the oral administration of Z-300 to rat, and disappeared from the systemic circulation with a half-life of 0.8-1.6 h. The bioavailability of Z-300 was 39% after the oral administration of Z-300, 10?mg/kg, and there was a non-linear relationship between the plasma level-time profile of Z-300 and the administered dose (3-50?mg/kg). 3. The binding of Z-300 to plasma protein was 92% in man, 65% in dog and 25% in rat. It is suggested that these species differences were due to the content of α1-acid glycoprotein (α1-AG), because Z-300 bound more strongly to α1-AG than to albumin. 相似文献
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SHUICHIRO SHIINA YUTAKA KOMATSU TAKAO KAWABE KENTA YOSHIURA EIJI HAMADA YASUO HATA YASURO NIWA TAKAO KAWASE SHINICHI OTA YASUSHI SHIRATORI AKIRA TERANO TSUNEAKI SUGIMOTO 《Journal of gastroenterology and hepatology》1992,7(2):154-156
Cholestatic hepatocellular carcinoma, which grows into the bile duct and causes obstructive jaundice, is rare and difficult to diagnose. A case is presented in which cholestatic hepatocellular carcinoma was detected by deposit of Lipiodol. This is also the first case that was successfully treated by endoscopic retrograde biliary drainage and transcatheter arterial embolization. 相似文献
10.
Hiroyasu KOIZUMI Eiichi SUEHIRO Yuichi FUJIYAMA Kazutaka SUGIMOTO Takao INOUE Michiyasu SUZUKI 《Neurologia medico-chirurgica》2014,54(11):870-877
Intracranial pressure (ICP) measurements are fundamental in the present protocols for intensive care of patients during the acute stage of severe traumatic brain injury. However, the latest report of a large scale randomized clinical trial indicated no association of ICP monitoring with any significant improvement in neurological outcome in severely head injured patients. Aggressive treatment of patients with therapeutic hypothermia during the acute stage of traumatic brain injury also failed to show any significant beneficial effects on clinical outcome. This lack of significant results in clinical trials has limited the therapeutic strategies available for treatment of severe traumatic brain injury. However, combined application of different types of neuromonitoring, including ICP measurement, may have potential benefits for understanding the pathophysiology of damaged brains. The combination of monitoring techniques is expected to increase the precision of the data and aid in prevention of secondary brain damage, as well as assist in determining appropriate time periods for therapeutic interventions. In this study, we have characterized the techniques used to monitor patients during the acute severe traumatic brain injury stage, in order to establish the beneficial effects on outcome observed in clinical studies conducted in the past and to follow up any valuable clues that point to additional strategies for aggressive management of these patients. 相似文献