全文获取类型
收费全文 | 546篇 |
免费 | 36篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 67篇 |
妇产科学 | 16篇 |
基础医学 | 83篇 |
口腔科学 | 2篇 |
临床医学 | 50篇 |
内科学 | 85篇 |
皮肤病学 | 31篇 |
神经病学 | 53篇 |
特种医学 | 16篇 |
外科学 | 91篇 |
综合类 | 2篇 |
预防医学 | 20篇 |
眼科学 | 11篇 |
药学 | 25篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 10篇 |
2020年 | 9篇 |
2019年 | 8篇 |
2018年 | 5篇 |
2017年 | 10篇 |
2016年 | 7篇 |
2015年 | 11篇 |
2014年 | 13篇 |
2013年 | 27篇 |
2012年 | 22篇 |
2011年 | 36篇 |
2010年 | 10篇 |
2009年 | 19篇 |
2008年 | 37篇 |
2007年 | 32篇 |
2006年 | 39篇 |
2005年 | 23篇 |
2004年 | 23篇 |
2003年 | 22篇 |
2002年 | 24篇 |
2001年 | 15篇 |
2000年 | 14篇 |
1999年 | 15篇 |
1998年 | 15篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 10篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 10篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1987年 | 10篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有582条查询结果,搜索用时 15 毫秒
1.
As a result of a perceived increase in pit bull injuries, all children who presented to The Children's Hospital of Philadelphia during 1989 for evaluation of dog bite injuries were prospectively studied. Epidemiologic information was collected from parents, either at the time of visit or by phone on the following day. A total of 168 children were enrolled; the mean age was 8 years. Males outnumbered females 1.5:1. Most (61%) injuries occurred in or around the home and involved dogs known to the patient (77%). Types of injuries included abrasions (33%), punctures (29%), and lacerations (38%). Thirteen bites had associated complications; nine developed infection. Twelve (7%) children required admission to the hospital. More than 12 different purebreeds or cross-breeds were identified as perpetrators, including German shepherds (n = 35), pit bulls (n = 33), rottweilers (n = 9), and Dobermans (n = 7). Most (54%) animals were contained (ie, leashed, fenced, in-house) at the time of injury. Fewer (46%) were provoked prior to biting. Significantly more pit bull injuries (94% vs 43%, P less than .001) were the consequence of unprovoked attacks and involved freely roaming animals (67% vs 41%, P less than .01). Children aged 5 or younger were more likely to provoke animals prior to injury than were older children (69% vs 36%, P less than .001). It is recommended that families with young children be the target of pet safety education and that measures be sought that would lead to early identification of a potentially dangerous dog and restrict ownership. 相似文献
2.
Joseph Levine Mirtha Gonsalves Izak Babur Shaul Stier Avner Elizur Ora Kofman R. H. Belmaker 《Human psychopharmacology》1993,8(1):49-53
Inositol is an important precursor for second messenger synthesis and has been reported to be reduced by lithium treatment in rat brain and in human CSF in depression. An open trial of 6 g/day in 11 depressed patients resistant to previous treatment led to major improvement in nine patients. The enzyme synthesizing inositol has been reported to be elevated in schizophrenia, suggesting an attempted compensation for possible inositol deficiency. A controlled double-blind crossover trial in 10 chronic schizophrenic patients of 6 g/day of inositol for 30 days did not reveal any benefit. 相似文献
3.
Philip Avner Maja Bućan Danielle Arnaud Hans Lehrach Ulf Rapp 《Somatic Cell and Molecular Genetics》1987,13(3):267-272
The localization of the A-rafcellular oncogene on the mouse X chromosome has been determined using Xbal-restricted DNAs prepared from progeny of an interspecies backcross between the B6.CBA.R1 and the Spe/Pas mouse strains. This localization to the proximal part of the mouse X chromosome has been confirmed by the use of somatic cell hybrids, carrying partially deleted X chromosomes and suggests that the A-raf oncogene localizes to a region lying some 10–17 centimorgans proximal to the hypoxanthine phosphoribosyltransferase (Hprt) gene between the locus DXPas4and the locus DXPas7defined by the cross-reacting human X chromosome-specific probe DXS32 (M2C). This localization on the mouse X chromosome is compatible with the presence of the A-rafoncogene on the short arm of the human X chromosome between the centromere and Xp21. 相似文献
4.
Yaron Bar-Dayan M. Eric Gershwin Yair Levi Howard Amital Dr. Yehuda Shoenfeld 《Immunologic research》1998,18(2):117-123
Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic liver disease, which is invariably fatal. Circumstantial and indirect evidence suggests that autoimmune mechanisms have a role in the pathogenesis of PBC. Antimitochondrial antibodies (AMA) are highly sensitive and specific markers that can predict the development of the disease in a healthy individual. Long-term administration of ursodeoxycholic acid (UDCA), a naturally occurring bile acid, safely slows the progression of PBC, delays the need for liver transplantation, and postpones death. An effort should be made to identify the patients with PBC in the asymptomatic stage by the presence of AMA and to conduct a clinical trial in order to assess the benefit of long-term administration of UDCA on the prevention of the overt disease in these individuals. 相似文献
5.
Avner ED 《Kidney international》1999,56(5):1962-1963
6.
Janet Li Paul Roche Jenean Spencer Ivan Bastian Amanda Christensen Mark Hurwitz Anastasios Konstantinos Vicki Krause Moira McKinnon Avner Misrachi Graham Tallis Justin Waring 《Communicable diseases intelligence》2004,28(4):464-473
The National Notifiable Disease Surveillance System (NNDSS) received 982 tuberculosis (TB) notifications in 2003, of which 947 were new cases, 33 were relapses and two were cases with unknown history. The incidence of TB in Australia has remained at a stable rate since 1985 and was 4.9 cases per 100,000 population in 2003. The high-incidence groups remain people born overseas and Indigenous Australians at 19.9 and 8.7 cases per 100,000 population, respectively. By contrast the incidence in non-Indigenous Australians was 0.9 per 100,000. Comparison of the 2003 TB notification data against the performance indicators set by National Tuberculosis Advisory Committee highlights that enhanced TB control measures should be considered among these high-risk groups. 相似文献
7.
8.
9.
Objective. To evaluate inhalation device cleaning practices of children with asthma and its effect on their asthma morbidity. Methods. A survey of patients aged 4 to 18 years admitted to an urban pediatric emergency department (ED) with an acute asthma exacerbation. Questions included demographics, asthma history, preference of delivery devices, and frequency of device cleaning. Patients were followed until their disposition from the ED, or until the end of their hospitalization, if admitted. Results. 220 subjects completed the survey. Mean age was 9.2 (± 3.9) years-old. One hundred and four (47.3%) patients used both nebulizers and spacer devices, while 18 (8.1%) used spacers only and 98 (44.5%) used nebulizers alone. Seventy-seven (38.1%; 95%CI: 31.7%–45.0%) patients cleaned their nebulizers and 57 (46.7%; 95%CI: 38.1%–55.4%) cleaned their spacer devices after each use as recommended by the Centers for Disease Control. There were no detectable differences in visit admission rate, total number of previous admissions, number of asthma exacerbations per year, and number of ED visits in one year between users who cleaned their devices after every, or every other use, compared to those who cleaned their devices less frequently. Conclusion. Although the majority of patients did not follow accepted guidelines for inhalation device cleaning, further studies are necessary to correlate cleaning practices to patients' clinical outcome. 相似文献
10.
Bar Meir E Amital H Levy Y Kneller A Bar-Dayan Y Shoenfeld Y 《Acta haematologica》2000,103(2):112-115
Thrombotic thrombocytopenic purpura (TTP) is a fatal disease characterized by widespread platelet aggregation, hemolytic anemia and fever with renal and neurological involvement. Different factors have been associated with the development of TTP, e.g. infections, pregnancy, chemotherapy, drug therapy and bone marrow transplantation. Recent data imply that all these different causes may induce the disease by decreasing the activity of the plasma von Willebrand factor-cleaving protease resulting in unusually large von Willebrand factor multimers that later on initiate the cascade of TTP. In this communication, we present a unique association between infection with Mycoplasma pneumoniae and TTP. We believe that the emergence of antibodies that cross-react with Mycoplasma and the protease might elucidate in this case the pathogenesis of TTP. 相似文献