经络实质之我见

目的：探讨经络研究的正确方向。方法：本于中医唯象思维结合经络的现代研究，分析研究经络实质具体性地归属某一种解剖关系的不合理性和经络现象与人体生命功能活动的关系。结论：经络是人体生命活动的总功能态。     

改进灼烙法对慢性扁桃体炎临床及免疫功能的研究

目的观察灼烙法治疗慢性扁桃体炎的疗效及其对患者T细胞亚群的影响.方法采用灼烙法治疗慢性扁桃体炎90例,随访6月评定疗效.治疗前及随访结束时分别检测患者T细胞亚群,评定其变化趋势.结果本组病例总有效率97.78%,治疗后T细胞亚群数明显提高.结论灼烙法治疗慢性扁桃体炎有效,并可提高患者T细胞亚群数目.     

Diagnostic Accuracy of Bronchodilator Response for Asthma in a Population of South China

Introduction

A significant bronchodilator response is commonly defined as a 12% or greater and 200 ml or greater change in FEV₁ from baseline according to the 2005 American Thoracic Society (ATS)/European Respiratory Society (ERS) criterion. A number of studies have shown that the ATS/ERS criterion has limitations in asthma diagnosis, and some experts have argued for correcting the criteria. The aim of this study is to investigate the diagnostic value of acute bronchodilator response for asthma in a Southern Chinese population.

Methods

We prospectively evaluated 805 patients with obstructive lung disease (309 for asthma, 496 for non-asthma). Spirometry was performed according to the ATS/ERS guidelines. Data were analyzed by SPSS 18.0. The receiver-operating characteristic (ROC) curve was drawn to assess the diagnostic accuracy of the ATS/ERS criterion based on FEV₁. Linear regression was used to analyze the factors of FEV₁ change.

Results

The sensitivity and specificity of the acute bronchodilator test when judged by the ATS/ERS criteria (200 ml or higher and 12% improvement) were 68.6% and 78.2%, respectively. For the ATS/ERS criteria, the Youden Index, which comprehensively reflects the authenticity of a diagnostic test, was 46.8%. The absolute change of FEV₁ positively correlated with baseline FEV₁ and weight and negatively with age, while the percentage change of FEV₁ was negatively correlated with baseline FEV₁, age and height and positively with weight. Compared with the different diagnostic values, when ?FEV₁ was 195 ml and ?FEV_1i% was 14%, the Youden Index was the largest (48.2%) and the diagnostic capability of the test the biggest.

Conclusions

The ATS/ERS criterion for acute bronchodilator response might not be completely suitable for asthma in the Chinese population.

Trial Registration

Chinese Clinical Trial Registry (Registry ID: ChiCTR-DDT-14004976).

Funding

This work was supported by the National Natural Science Foundation of China (grant nos. 81670027, 81270080).

     

应用丙种球蛋白治疗病毒性脑炎的临床研究

目的:探讨应用静丙治疗病毒性脑炎的临床价值。方法:在常规治疗(脱水降颅压、降温止惊、激素、抗生素、能量合剂及对症处理等)的基础上加用蓉生静丙(200—400mg/kg.d,×4—5d)治疗病脑。结果:治疗组与对照组间在治疗发热、头痛、呕吐、抽搐、平均住院日数等诸方面比较,均有显著性差异(P<0.01)。结论:病脑治疗中,在常规疗法基础上加用静丙静滴治疗,可显著提高疗效。     

影响中国人口平均预期寿命的社会因素模式

本文以全国28个省、自治区和直辖市的统计资料为基础,以文化、经济等社会因素作为自变量,平均预期寿命作为因变量,应用多元线性回归分析,对影响我国人口平均预期寿命的社会因素模式作一讨论。结果提示:努力提高人民文化水平,发展社会主义经济和促进医疗卫生事业的发展是提高人口预期寿命的重要“社会处方”。     

影响男女性人口寿命变化的病因探讨

本文用改良式净死亡概率模型研究影响阆中男女性寿命的因素。揭示新生儿病、急性传染病、消化系病、意外死亡、结核病、肺炎等死亡率的下降对寿命增长的贡献较大;恶性肿瘤、脑血管病死亡率的上升对寿命增长呈负贡献,以男性突出。其结果与阆中近十多年死亡模式的变化趋势基本一致。     

功能性肠病住院情况分析

目的　探讨功能性肠病 (FBD)住院发病情况、临床特点及住院耗资。方法　复习我院消化科 1999～ 2 0 0 2年期间住院的FBD和器质性肠病 ,比较两大类疾病临床特征、辅助检查及住院费用情况。结果　FBD 65例 ,器质性肠病167例。两组患者腹痛、腹泻、腹胀、便秘、厌食、乏力、体重下降均无显著性差异 (P >0 .0 5 ) ,FBD多伴随焦虑、抑郁和失眠 ,而便血、发热、潮热、盗汗、贫血、腹水征、腹部包块多提示器质性肠病。FBD多数检查异常发现率及平均每日住院费用较器质性肠病低 (P <0 .0 5 )。检查费用两组无显著性差异 ,而检查费用占住院费用比例FBD较器质性肠病高 (P <0 .0 5 )。结论　临床医师应提高对FBD认识 ,熟悉诊断标准 ,并合理安排检查     

血塞通联合参麦注射液治疗气虚血瘀型胸痹随机平行对照研究

[目的]观察血塞通联合参麦注射液治疗气虚血瘀型胸痹疗效。[方法]使用随机平行对照方法,将92例门诊患者按抽签法简单随机分为两组。对照组46例心痛定,10mg/次,3次/d;心绞痛发作硝酸甘油,0.5mg/次,舌下含服。治疗组46例血塞通400mg+0.9%生理盐水250mL,1次/d,静滴;参麦注射液30mL+5%葡萄糖250mL,1次/d,静滴。连续治疗7d为1疗程。观测临床症状、血液流变指标(全血高切黏度、全血低切黏度、血浆黏度)、心电图、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效29例,有效13例,无效4例,加重0例,总有效率91.30%。对照组显效12例,有效20例,无效11例,加重3例,总有效率69.57%。治疗组疗效优于对照组(P0.05)。血液指标治疗组有改善(P0.05),对照组无改善(P0.05),治疗组改善优于对照组(P0.05)。[结论]血塞通联合参麦注射液治疗气虚血瘀型胸痹效果显著,值得推广。     

HPLC一测多评法同时测定胃疡灵颗粒中8种成分的含量

目的:建立HPLC一测多评法同时测定胃疡灵颗粒中肉桂酸、桂皮醛、毛蕊异黄酮葡萄糖苷、芒柄花苷、芒柄花素、6-姜辣素、8-姜酚和10-姜酚的含量.方法:采用HPLC法,以Agilent SB-C18柱(250 mm×4.6 mm,5μm)为色谱柱,流动相A为乙腈-甲醇(9:1),流动相B为0.1％ 磷酸溶液,梯度洗脱(0...     

Compound facial expressions of emotion: from basic research to clinical applications

Emotions are sometimes revealed through facial expressions. When these natural facial articulations involve the contraction of the same muscle groups in people of distinct cultural upbringings, this is taken as evidence of a biological origin of these emotions. While past research had identified facial expressions associated with a single internally felt category (eg, the facial expression of happiness when we feel joyful), we have recently studied facial expressions observed when people experience compound emotions (eg, the facial expression of happy surprise when we feel joyful in a surprised way, as, for example, at a surprise birthday party). Our research has identified 17 compound expressions consistently produced across cultures, suggesting that the number of facial expressions of emotion of biological origin is much larger than previously believed. The present paper provides an overview of these findings and shows evidence supporting the view that spontaneous expressions are produced using the same facial articulations previously identified in laboratory experiments. We also discuss the implications of our results in the study of psychopathologies, and consider several open research questions.