全文获取类型
收费全文 | 87529篇 |
免费 | 6996篇 |
国内免费 | 4213篇 |
专业分类
耳鼻咽喉 | 1181篇 |
儿科学 | 1055篇 |
妇产科学 | 840篇 |
基础医学 | 9429篇 |
口腔科学 | 1539篇 |
临床医学 | 8858篇 |
内科学 | 12587篇 |
皮肤病学 | 1345篇 |
神经病学 | 4136篇 |
特种医学 | 4302篇 |
外国民族医学 | 8篇 |
外科学 | 11537篇 |
综合类 | 14401篇 |
现状与发展 | 15篇 |
一般理论 | 16篇 |
预防医学 | 6298篇 |
眼科学 | 1959篇 |
药学 | 8486篇 |
57篇 | |
中国医学 | 4301篇 |
肿瘤学 | 6388篇 |
出版年
2024年 | 178篇 |
2023年 | 864篇 |
2022年 | 2161篇 |
2021年 | 3241篇 |
2020年 | 2406篇 |
2019年 | 2187篇 |
2018年 | 2452篇 |
2017年 | 2347篇 |
2016年 | 2461篇 |
2015年 | 3680篇 |
2014年 | 4674篇 |
2013年 | 5177篇 |
2012年 | 7620篇 |
2011年 | 7750篇 |
2010年 | 5802篇 |
2009年 | 5017篇 |
2008年 | 5834篇 |
2007年 | 5638篇 |
2006年 | 5294篇 |
2005年 | 4563篇 |
2004年 | 3563篇 |
2003年 | 3386篇 |
2002年 | 2942篇 |
2001年 | 2242篇 |
2000年 | 1617篇 |
1999年 | 1092篇 |
1998年 | 519篇 |
1997年 | 512篇 |
1996年 | 367篇 |
1995年 | 304篇 |
1994年 | 260篇 |
1993年 | 170篇 |
1992年 | 255篇 |
1991年 | 275篇 |
1990年 | 207篇 |
1989年 | 192篇 |
1988年 | 168篇 |
1987年 | 182篇 |
1986年 | 144篇 |
1985年 | 128篇 |
1984年 | 87篇 |
1983年 | 87篇 |
1982年 | 52篇 |
1979年 | 72篇 |
1978年 | 43篇 |
1977年 | 46篇 |
1975年 | 46篇 |
1974年 | 46篇 |
1973年 | 44篇 |
1969年 | 45篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Tian-Yuan Xiong Fang-Yang Huang Qi Liu Yong Peng Yuan-Ning Xu Jia-Fu Wei 《Annals of medicine》2020,52(7):361-366
Abstract
Background
Comorbidities are commonly seen in patients with coronavirus disease 2019 (COVID-19), but the clinical implication is not yet well-delineated. We aim to characterize the prevalence and clinical implications of comorbidities in patients with COVID-19. 相似文献3.
4.
5.
6.
7.
Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed. 相似文献
8.
9.
Bi-Hua BIE Yong CHEN Zhi-Qi ZHAO Institute of Neurobiology Fu-Dan University Shanghai China Institute of Shanghai Physiology Chinese Academy of Sciences Shanghai China 《中国神经科学杂志》2006,(2)
Objective Ligustrazine, also named as tetramethylpyrazine, is a compound purified from Ligusticum chuanxiong hort and has ever been testified to be a calcium antagonist. The present investigation was to determine the antinoci-ceptive effect of ligustrazine and, if any, the peripheral ionic mechanism involved. Methods Paw withdrawal Latency ( PWL) to noxious heating was measured in vivo and whole-cell patch recording was performed on small dorsal root ganglion (DRG) neurons. Results Intraplantar injection of ligustrazine (0.5 mg in 25μl) significantly prolonged the withdrawal latency of ipsilateral hindpaw to noxious heating in the rat. Ligustrazine not only reversibly inhibited high-voltage gated calcium current of dorsal root ganglion (DRG) neuron in dose-dependent manner with IC50 of 1.89 mmol/L, but also decreased tetrodotoxin (TTX) -resistant sodium current in relatively selective and dose-dependent manner with IC50 of 2.49 mmol/L. Conclusion The results suggested that ligustrazine could elevate the threshold of thermal nociception through inhibiting the high-voltage gated calcium current and TTX-resistant sodium current of DRG neuron in the rat. 相似文献
10.
J Phua E S C Koay D Zhang L K Tai X L Boo K C Lim T K Lim 《The European respiratory journal》2006,28(4):695-702
Levels of the soluble form of the triggering receptor expressed on myeloid cells (sTREM)-1 are elevated in severe sepsis. However, it is not known whether sTREM-1 measurements can distinguish milder bacterial infections from noninfectious inflammation. The present authors studied whether serum sTREM-1 levels differ in community-acquired pneumonia, exacerbations of chronic obstructive pulmonary disease (COPD), asthma and controls, and whether sTREM-1 may be used as a surrogate marker for the need for antibiotics. Serum sTREM-1 levels in 150 patients with pneumonia, COPD and asthma exacerbations and 62 healthy controls were measured. Serum sTREM-1 levels were significantly elevated in pneumonia (median 295.2 ng x mL(-1)), COPD (280.3 ng x mL(-1)) and asthma exacerbations (184.0 ng x mL(-1)) compared with controls (83.1 ng x mL(-1)). Levels were higher in pneumonia and Anthonisen type 1 COPD exacerbations than in type 2 and 3 COPD and asthma exacerbations. The area under the receiver operating characteristics curve for sTREM-1 as a surrogate marker for the need for antibiotics was 0.77. Serum levels of the soluble form of the triggering receptor expressed on myeloid cells-1 were elevated predominantly in pneumonia and Anthonisen type 1 COPD exacerbations versus type 2 and 3 chronic obstructive pulmonary disease exacerbations, asthma and controls. Serum levels of the soluble form of the triggering receptor expressed on myeloid cells-1 has moderate but insufficient accuracy as a surrogate marker for the need for antibiotics in lower respiratory tract infections. 相似文献