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排序方式: 共有1417条查询结果,搜索用时 15 毫秒
1.
Peter J. Morgan Lynda M. Williams Gary Davidson Wilfred Lawson Edward Howell 《Journal of neuroendocrinology》1989,1(1):1-4
The functional significance of the pars tuberalis (PT) of the mammalian adenohypophysis has remained an enigma (1, 2). One view of its function is that it acts as an auxiliary gland to support the endocrine role of the pars distalis (PD) (2), as it has been shown to contain immunocytochemically identifiable thyrotrophs and gonadotrophs (1). Many of the cells of the PT are, however, ultrastructurally unique suggesting an independent function for this tissue. Our recent demonstration that the PT of the rat is a major binding site for the ligand iodomelatonin lends further support to this idea (3). We have utilized the highly specific ligand [125 l]melatonin, and have demonstrated that it binds exclusively, with very high affinity, to the PT but not the PD of the adult sheep adenohypophysis. These findings support the conclusion that the PT has a distinct role in relation to melatonin action and seasonal reproduction. 相似文献
2.
Deoxycholic acid (DA) caused a dose-related release of histamine (HR) from mast cells of rat peritoneum (RPMC) and mucosal cells of guinea pig rectocolon (RCMC). In both cell populations, DA-induced HR was: (1) accompared by a parallel release of lactate dehydrogenase (LDH), (2) not affected by metabolic inhibitors, (3) dependent on time of incubation, temperature and pH, and affected by Ca++ concentration in RPMC but not in RCMC. DA-induced HR from RCMC may be involved in certain functional disorders of the colon. 相似文献
3.
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5.
Wilfred C. G. Peh F.R.C.R. Louis A. Gilula M.D. Max R. Kasselt M.D. 《Emergency radiology》1997,4(4):255-257
Automobile air bag inflation-caused injuries to the chest, neck, and face, in particular the orbital contents, are infrequent but recognized. We report the occurrence of multiple digital fractures in the left hand of a 30-yearold male driver as a result of sudden air bag inflation. Continued monitoring of the potential hazards of this device is suggested. 相似文献
6.
7.
The pattern and frequency of t(14;18) translocation and immunophenotype in Asian follicular lymphoma 总被引:2,自引:0,他引:2
AIMS: Follicular lymphoma is frequently associated with t(14;18)(q32;q21) translocation. This study was undertaken to determine the pattern of Bcl-2, CD10 and Bcl-6 expression in relation to t(14;18) translocation in follicular lymphoma from a cohort of a multi-ethnic Asian population. METHODS AND RESULTS: Sixty-two cases of follicular lymphoma were retrieved for immunohistochemistry, and t(14;18) translocation analysis by polymerase chain reaction and fluorescent in-situ hybridization techniques. Bcl-2 expression was present in 74% of the cases. CD10 expression was also relatively low (61%), with decreasing frequency of expression in high-grade tumours. Bcl-6 protein was expressed in most of the tumours (88%) regardless of the tumour grade. The t(14;18) translocation was detected in 46 cases (74%) with an extremely high rate of t(14;18) translocation in ethnic Indian cases (100%). CONCLUSION: The frequency of t(14;18) translocation in this series of follicular lymphomas was higher when compared with previous Asian reports, but in accordance with European and North American findings. CD10 expression is strongly associated with a t(14;18) translocation event, but the overall CD10 expression was relatively low, possibly due to the high proportion of high-grade tumours in the series. t(14;18) translocation was not associated with Bcl-2 or Bcl-6 expression. 相似文献
8.
Osteochondroma and secondary synovial osteochondromatosis 总被引:1,自引:0,他引:1
Secondary synovial osteochondromatosis (SOC) is a rare disorder caused by a variety of joint disorders. Two unusual cases
of secondary SOC are presented. The first patient is a 43-year-old man with extensive SOC developing within a bursa surrounding
an osteochondroma of the pubic bone. The second patient is a 23-year-old man who developed florid and progressive SOC of his
hip joint following excision of a femoral neck osteochondroma. SOC recurred despite three excisions over a 15-month period.
Imaging was useful in pre-operative diagnosis of bursal SOC in the first patient and in detecting multiple recurrences in
the second patient. Both cases illustrate prominent SOC developing secondary to osteochondroma. The different hypotheses regarding
bursal and secondary SOC are reviewed.
Received: 8 October 1998 Revision requested: 28 October 1998 Revision received: 13 November 1998 Accepted: 16 November 1998 相似文献
9.
Intrafracture fluid: a new diagnostic sign of insufficiency fractures of the sacrum and ilium 总被引:2,自引:0,他引:2
Peh WC 《The British journal of radiology》2000,73(872):895-898
MRI is generally regarded as being sensitive but non-specific for the detection of insufficiency fractures affecting the sacrum and pelvic ring. The finding of intrafracture fluid is described in two elderly patients with insufficiency fractures. This MR feature is believed to be a new diagnostic sign of these fractures affecting the sacrum and ilium. 相似文献
10.
Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. 总被引:14,自引:0,他引:14
Philipp Str?bel Andrea Bauer Bernhard Puppe Til Kraushaar Axel Krein Klaus Toyka Ralf Gold Michael Semik Reinhard Kiefer Wilfred Nix Berthold Schalke Hans Konrad Müller-Hermelink Alexander Marx 《Journal of clinical oncology》2004,22(8):1501-1509
PURPOSE: Thymic epithelial tumors (TET) are rare epithelial neoplasms of the thymus with considerable histologic heterogeneity. This retrospective study focused on the correlation of WHO-defined TET histotypes with survival and tumor recurrence in a large cohort of patients receiving different modes of treatment. PATIENTS AND METHODS: Two hundred twenty-eight patients were followed for up to 21 years (median, 60 months; range, 1 to 252 months) after primary surgery. Forty-two patients received adjuvant radiotherapy (mean dose, 53 Gy), and 33 patients received adjuvant chemotherapy. RESULTS: Seventy-six (88%) of 86 patients with WHO type A, AB, and B1 thymomas were treated by surgery alone, with three tumor relapses after 3 to 10 years (median, 3.4 years). Twelve of 67 patients with WHO type B2 and B3 thymomas in Masaoka stages I and II were treated by adjuvant radiotherapy without evidence of tumor recurrence after 1 to 12 years (median, 4 years). Among 75 patients with B2 and B3 thymomas with incomplete resection or a tumor stage III or higher, the recurrence rate was 34% (n = 23) after 0.5 to 17 years (median, 5 years) in patients receiving adjuvant radiochemotherapy, compared to 78% (seven of nine patients) in patients without adjuvant radiochemotherapy. Incomplete tumor resection was associated with a high recurrence rate (65%) and a poor prognosis (P <.01). CONCLUSION: The long-term outcome of TET patients is related to tumor stage, WHO histotype, completeness of surgical removal, and type of treatment. Prospective trials are warranted to formally address the efficacy of adjuvant therapy in the treatment of localized and advanced malignant TETs. 相似文献