Verb argument structure weakness in specific language impairment in relation to age and utterance length

In spite of the complexity of verb argument structure, argument structure errors are infrequent in the speech of children with specific language impairment (SLI). The study examined the spontaneous argument structure use of school-age children with SLI and with normal language (NL) (n = 100). The groups did not differ substantially in frequency of argument structure errors, particularly when pragmatic context was considered. However, children with SLI used significantly fewer argument types, argument structure types and verb alternations than age-matched children with NL. Further, significant differences between children with SLI and mean length of utterance-matched controls were found involving the use of three-place argument structures. The results show that children with SLI demonstrate mostly correct, but less sophisticated, verb argument structure use than NL peers, and that the difference is not merely attributable to production limitations such as utterance length. The possibility of incomplete argument structure representation is suggested.     

Does dietary counseling improve quality of life in cancer patients? A systematic review and meta-analysis

Results have been mixed as to whether dietary counseling improves clinical outcomes in cancer patients. This systematic review and meta-analysis of randomized trials assessed the effect of dietary counseling on quality of life (QOL). It included only randomized trials that focused on dietary counseling and that relied upon a standardized QOL measurement. Five trials that met these and all other a priori eligibility criteria were identified; they are the focus of this meta-analysis. When these five studies were examined in aggregate, the standardized mean difference in QOL scores among patients who received dietary counseling was 0.56 (95% confidence interval,-0.01-1.14; P = 0.06). Dietary counseling does not appear to improve QOL significantly in patients with cancer. However,an observed trend toward benefit underscores the need for further study.     

Neurological and magnetic resonance imaging findings in children with developmental language impairment

Neurologic and radiologic findings in children with well-defined developmental language impairment have rarely been systematically assessed. Children aged 7 to 13 years with developmental language impairment or normal language (controls) underwent language, nonverbal cognitive, motor and neurological assessments, standardized assessment for subtle neurological signs, and magnetic resonance imaging. Nine children with developmental language impairment and 12 controls participated. No focal abnormalities were identified on standard neurological examination. Age and developmental language impairment were independent predictors of neurological subtle signs scores (r(2) = 0.52). Imaging abnormalities were identified in two boys with developmental language impairment and no controls (P = .17). Lesions identified were predicted neither by history nor by neurological examination. Previously unsuspected lesions were identified in almost 25% of children with developmental language impairment. Constraints regarding cooperation and sedation requirements may limit the clinical application of imaging modalities in this population.     

Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease with an age at onset generally below 65 years. Mutations in progranulin (GRN) have been reported to be able to cause FTLD through haploinsufficiency. We have sequenced GRN in 121 patients with FTLD and detected six different mutations in eight patients: p.Gly35Glufs*19, p.Asn118Phefs*4, p.Val200Glyfs*18, p.Tyr294*, p.Cys404* and p.Cys416Leufs*30. Serum was available for five of the mutations, where the serum-GRN levels were found to be >50% reduced compared with FTLD patients without GRN mutations. Moreover, the p.Cys416Leufs*30 mutation segregated in an affected family with different dementia diagnoses. The mutation frequency of GRN mutation was 6.6% in our FTLD cohort.     

Verb argument structure weakness in specific language impairment in relation to age and utterance length

In spite of the complexity of verb argument structure, argument structure errors are infrequent in the speech of children with specific language impairment (SLI). The study examined the spontaneous argument structure use of school-age children with SLI and with normal language (NL) ( n =100). The groups did not differ substantially in frequency of argument structure errors, particularly when pragmatic context was considered. However, children with SLI used significantly fewer argument types, argument structure types and verb alternations than agematched children with NL. Further, significant differences between children with SLI and mean length of utterance-matched controls were found involving the use of three-place argument structures. The results show that children with SLI demonstrate mostly correct, but less sophisticated, verb argument structure use than NL peers, and that the difference is not merely attributable to production limitations such as utterance length. The possibility of incomplete argument structure representation is suggested.     

Factors associated with participation frequency and satisfaction among people applying for a housing adaptation grant

Background: People applying for a housing adaptation (HA) grant are at great risk of participation restrictions due to declining capacity and environmental barriers.

Aim: To investigate the association of person-, environment-, and activity-related factors with participation frequency and satisfaction among people applying for a housing adaptation grant.

Material and methods: Baseline cross-sectional data were collected during home visits (n?=?128). The association between person-, environment-, and activity-related factors and participation frequency and satisfaction was analysed using logistic regressions.

Results: The main result is that frequency of participation outside the home is strongly associated with dependence in activities of daily living (ADL) and cognitive impairments, while satisfaction with participation outside the home is strongly associated with self-reported health. Moreover, aspects of usability in the home were associated with frequency of participation outside the home and satisfaction with participation in the home and outside the home alone.

Conclusion: Dependence in ADL, cognitive impairments, self-rated health, and aspects of usability are important factors contributing to participation frequency and satisfaction among people applying for a housing adaptation grant, particularly outside the home.

Significance: Our findings indicate that more attention should be directed towards activity-related factors to facilitate participation among HA applicants, inside and outside the home.     

Language-specific effects of task demands on the manifestation of specific language impairment: a comparison of English and Icelandic

PURPOSE: Previous research has indicated that the manifestation of specific language impairment (SLI) varies according to factors such as language, age, and task. This study examined the effect of task demands on language production in children with SLI cross-linguistically. METHOD: Icelandic- and English-speaking school-age children with SLI and normal language (NL) peers (n = 42) were administered measures of verbal working memory. Spontaneous language samples were collected in contexts that vary in task demands: conversation, narration, and expository discourse. The effect of the context-related task demands on the accuracy of grammatical inflections was examined. RESULTS: Children with SLI in both language groups scored significantly lower than their NL peers in verbal working memory. Nonword repetition scores correlated with morphological accuracy. In both languages, mean length of utterance (MLU) varied systematically across sampling contexts. Context exerted a significant effect on the accuracy of grammatical inflection in English only. Error rates were higher overall in English than in Icelandic, but whether the difference was significant depended on the sampling context. Errors in Icelandic involved verb and noun phrase inflection to a similar extent. CONCLUSIONS: The production of grammatical morphology appears to be more taxing for children with SLI who speak English than for those who speak Icelandic. Thus, whereas children with SLI in both language groups evidence deficits in language processing, cross-linguistic differences are seen in which linguistic structures are vulnerable when processing load is increased. Future research should carefully consider the effect of context on children's language performance.