全文获取类型
收费全文 | 2680篇 |
免费 | 122篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 55篇 |
妇产科学 | 60篇 |
基础医学 | 352篇 |
口腔科学 | 58篇 |
临床医学 | 143篇 |
内科学 | 685篇 |
皮肤病学 | 111篇 |
神经病学 | 191篇 |
特种医学 | 68篇 |
外科学 | 404篇 |
综合类 | 4篇 |
预防医学 | 51篇 |
眼科学 | 5篇 |
药学 | 274篇 |
中国医学 | 17篇 |
肿瘤学 | 302篇 |
出版年
2023年 | 10篇 |
2022年 | 22篇 |
2021年 | 42篇 |
2020年 | 39篇 |
2019年 | 23篇 |
2018年 | 37篇 |
2017年 | 32篇 |
2016年 | 45篇 |
2015年 | 50篇 |
2014年 | 56篇 |
2013年 | 80篇 |
2012年 | 101篇 |
2011年 | 130篇 |
2010年 | 69篇 |
2009年 | 58篇 |
2008年 | 112篇 |
2007年 | 151篇 |
2006年 | 152篇 |
2005年 | 156篇 |
2004年 | 130篇 |
2003年 | 147篇 |
2002年 | 152篇 |
2001年 | 62篇 |
2000年 | 63篇 |
1999年 | 84篇 |
1998年 | 44篇 |
1997年 | 31篇 |
1996年 | 44篇 |
1995年 | 44篇 |
1994年 | 30篇 |
1993年 | 40篇 |
1992年 | 58篇 |
1991年 | 47篇 |
1990年 | 41篇 |
1989年 | 43篇 |
1988年 | 46篇 |
1987年 | 40篇 |
1986年 | 39篇 |
1985年 | 34篇 |
1984年 | 24篇 |
1983年 | 22篇 |
1982年 | 14篇 |
1981年 | 15篇 |
1980年 | 14篇 |
1979年 | 15篇 |
1973年 | 11篇 |
1971年 | 12篇 |
1970年 | 12篇 |
1969年 | 11篇 |
1967年 | 9篇 |
排序方式: 共有2818条查询结果,搜索用时 15 毫秒
1.
2.
K U Chu S Higashide B M Evers S Rajaraman J Ishizuka C M Townsend Jr J C Thompson 《Annals of surgery》1994,220(4):570-577
OBJECTIVE: The authors determined whether bombesin could improve survival from methotrexate (MTX)-induced enterocolitis. SUMMARY BACKGROUND DATA: Bombesin prevents gut mucosal atrophy, which is produced by feeding rats an elemental diet. Administration of MTX produces a lethal enterocolitis in rats fed an elemental diet. METHODS: On treatment day 0, 60 rats were divided randomly into three groups and fed an elemental diet (Vivonex TEN, Sandoz, Minneapolis, MN) as the only source of nutrition. Groups were subdivided further to receive either saline or bombesin (10 micrograms/kg, subcutaneously, three times a day) beginning either on day 0 or day 14. Methotrexate (20 mg/kg, intraperitoneally) was given to all rats 14 days after the start of an elemental diet. RESULTS: Bombesin prevented the mucosal atrophy in the ileum produced by the elemental diet and significantly decreased mortality in rats given MTX (whether given as a pretreatment or at the time of MTX administration). CONCLUSION: Bombesin significantly improved survival in a lethal model of MTX-induced enterocolitis, possibly by maintaining gut mucosal structure. Administration of bombesin to patients receiving chemotherapy may be clinically useful in preventing the severe enterocolitis induced by various chemotherapeutic agents. 相似文献
3.
4.
5.
Hiroki Sato Atsushi Watanabe Tamotsu Yamaguchi Nobuhiro Harada Akihiko Yamauchi Satomi Inoue Tomio Abe 《Annals of thoracic and cardiovascular surgery》2005,11(1):41-43
Intralobar pulmonary sequestration associated with asymptomatic aspergillosis is a rare case. We describe the case of a 65-year-old woman with intrapulmonary sequestration, anomalous systemic arterial supply to the left lower lobe and aspergillosis who underwent left lower lobectomy and ligation of an anomalous artery by Video-Assisted Thoracoscopic surgery (VATS). Pathological examination showed the parenchymal distortion and chronic inflammation. Aspergillus were found in the cyst. VATS lobectomy for intralobar pulmonary sequestration is a safe and valid procedure. 相似文献
6.
7.
Basic and clinical studies have been performed on imipenem/cilastatin sodium (MK-0787/MK-0791) in the pediatric field. Antibacterial activities of MK-0787 against 14 clinical isolates of S. aureus and 67 isolates of E. coli were determined. The MIC of MK-0787 was 0.10 microgram/ml or less against all 14 strains of S. aureus. The MIC of MK-0787 was 0.39 microgram/ml or less against all 67 strains of E. coli. The pharmacokinetics of MK-0787/MK-0791 was studied at dose levels of 10 mg/10 mg/kg and 20 mg/20 mg/kg. The peak serum levels of MK-0787 achieved approximately 1 hour after the administration of 10 mg/10 mg/kg and 20 mg/20 mg/kg doses were 38.6 micrograms/ml and 36.2 micrograms/ml, respectively. The serum half-lives were 0.8 hour and 0.9 hour, respectively. The total 6-hour urinary excretions were 82.1% and 66.7%, respectively. The MK-0787/MK-0791 was administered to 13 children with bacterial infections. The clinical results were excellent or good in all cases. The overall efficacy rate was 100%. As a side effect, diarrhea was observed in 1 patient. Abnormalities in laboratory findings observed were elevation of direct bilirubin in 1 patient, thrombocytosis in 2, and a prolonged prothrombin time in 1 patient. Based on the above results, it can be concluded that MK-0787/MK-0791 is a safe and effective drug to use for the treatment of pediatric infections. 相似文献
8.
Hiroshi Uno Yoshihiro Izawa Kiyoshi Sagara Tamotsu Koyama Tokutaro Makita Chia-Yuan Hsu-Chang Mitsugi Sugiyama 《Journal of bone and mineral metabolism》1990,8(1):10-16
The effect of 1α-hydroxyvitamin D3 (1α(OH)D3) on the metabolic bone disorders developed in gastrectomized rats were investigated biochemically and histomorphologically.
1α(OH)D3 was suspended in 0.2 % Triton-X-100 aqueous solution after dissolving in a very small amount of ethanol, was given orally
to the rats for 10 weeks. The sham operated animals and the gastrectomy control animals received the vehicle alone. Gastrectomy
was followed by the development of the metabolic bone disorders after 10 weeks of observation. This was characterized by reduction
in ash content of the femur and histologically by a disappearance of the trabecular bone in tibial metaphysis. Decrease Ca
absorption from the intestines was demonstrated by a radiotracer technique. Biochemical studies showed significant decreases
in serum 25(OH)D concentration in gastrectomized rats. These findings suggest that gastrectomy partially impairs intestinal
absorption of calcium and results in a negative calcium balance, which may contribute to the development of bone metabolic
disorders in rats. The administration of 1α(OH)D3 increased dose-dependently serum calcium and Ca absorption from the intestine and prevented the development of bone metabolic
disorders histomorphologically. 相似文献
9.
To examine whether prostacyclin has an attenuating effect on nonspecific bronchial responsiveness in asthma, we measured provocative concentration of methacholine producing a 20% fall in forced expiratory volume in 1 second (PC20-FEV1) before and after oral administration of a chemically stable prostacyclin analog (OP-41483) (200 μg 4 times a day for 4 days) in 8 patients with stable asthma. Neither baseline pulmonary function nor PC20-FEV1 significantly improved after the treatment. These results suggest that prostacyclin may have no direct effect on bronchial responsiveness in asthmatics. Further studies using more potent and long-lasting prostacyclin mimetic will be needed to confirm the conclusion. 相似文献
10.