全文获取类型
收费全文 | 673篇 |
免费 | 51篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 22篇 |
妇产科学 | 31篇 |
基础医学 | 77篇 |
口腔科学 | 22篇 |
临床医学 | 65篇 |
内科学 | 107篇 |
皮肤病学 | 16篇 |
神经病学 | 46篇 |
特种医学 | 29篇 |
外科学 | 78篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 78篇 |
眼科学 | 30篇 |
药学 | 56篇 |
中国医学 | 7篇 |
肿瘤学 | 36篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 17篇 |
2021年 | 37篇 |
2020年 | 31篇 |
2019年 | 39篇 |
2018年 | 54篇 |
2017年 | 33篇 |
2016年 | 25篇 |
2015年 | 28篇 |
2014年 | 31篇 |
2013年 | 38篇 |
2012年 | 65篇 |
2011年 | 58篇 |
2010年 | 43篇 |
2009年 | 17篇 |
2008年 | 33篇 |
2007年 | 35篇 |
2006年 | 16篇 |
2005年 | 21篇 |
2004年 | 14篇 |
2003年 | 15篇 |
2002年 | 18篇 |
2001年 | 5篇 |
2000年 | 6篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1994年 | 5篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1970年 | 1篇 |
排序方式: 共有727条查询结果,搜索用时 28 毫秒
1.
2.
Background
Cardiovascular disease remains the leading killer of women in most developed areas of the world. Rates of physical inactivity and poor nutrition, which are two of the most important modifiable risk factors for cardiovascular disease in women, are substantial. This study sought to examine the effectiveness of a community-based lifestyle-modification program on increasing women's physical activity in a randomized trial guided by community-based participatory research (CBPR) methods. 相似文献3.
4.
An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line 总被引:2,自引:0,他引:2
Wang Y Xue H Cutz JC Bayani J Mawji NR Chen WG Goetz LJ Hayward SW Sadar MD Gilks CB Gout PW Squire JA Cunha GR Wang YZ 《Laboratory investigation; a journal of technical methods and pathology》2005,85(11):1392-1404
Metastasis is the major cause of prostate cancer deaths and there is a need for clinically relevant in vivo models allowing elucidation of molecular and cellular mechanisms underlying metastatic behavior. Here we describe the development of a new in vivo model system for metastatic prostate cancer. Pieces of prostate cancer tissue from a patient were grafted in testosterone-supplemented male NOD-SCID mice at the subrenal capsule graft site permitting high tumor take rates. After five serial transplantations, the tumor tissues were grafted into mouse prostates. Resulting tumors and suspected metastatic lesions were subjected to histopathological and immunohistochemical analysis. Samples of metastatic tissue were regrafted in mouse anterior prostates and their growth and spread examined, leading to isolation from lymph nodes of a metastatic subline, PCa1-met. Orthotopic grafting of PCa1-met tissue in 47 hosts led in all cases to metastases to multiple organs (lymph nodes, lung, liver, kidney, spleen and, notably, bone). Histopathological analysis showed strong similarity between orthotopic grafts and their metastases. The latter were of human origin as indicated by immunostaining using antibodies against human mitochondria, androgen receptor, prostate-specific antigen and Ki-67. Spectral karyotyping showed few chromosomal alterations in the PCa1-met subline. This study indicates that transplantable subrenal capsule xenografts of human prostate cancer tissue in NOD-SCID mice can, as distinct from primary cancer tissue, be successfully grown in the orthotopic site. Orthotopic xenografts of the transplantable tumor lines and metastatic sublines can be used for studying various aspects of metastatic prostate cancer, including metastasis to bone. 相似文献
5.
Md R. Rahaman Karen A. Alroy Chris A. Van Beneden Michael S. Friedman Erin D. Kennedy Mahmudur Rahman Arunmozhi Balajee A.K.M. Muraduzzaman Tahmina Shirin Meerjady S. Flora Eduardo Azziz-Baumgartner 《Emerging infectious diseases》2021,27(1):324
In April 2017, surveillance detected a surge in severe acute respiratory infections (SARI) in Bangladesh. We collected specimens from SARI patients and asymptomatic controls for analysis with multipathogen diagnostic tests. Influenza A(H1N1)pdm09 was associated with the SARI epidemic, suggesting that introducing vaccines and empiric antiviral drugs could be beneficial. 相似文献
6.
Saeed Shoar Fatemeh Sadat Hosseini Azouba Gulraiz Waleed Ikram Moiz Javed Mohammad Naderan Nasrin Shoar Venkat R. Modukuru 《Surgery for obesity and related diseases》2021,17(3):630-643
Even in the hands of highly experienced bariatric surgeons, perioperative complications are inevitable. Of these, leaks and fistulas are amongst the scariest complications. Intrathoracic gastric fistulas (ITGF) can be associated with serious morbidity, mostly when cases are misdiagnosed or detected with delay. This is a systematic review of the literature to investigate the clinical and surgical outcomes of morbidly obese adult patients with a confirmed diagnosis of ITGF following bariatric surgery. A pooled analysis of 25 articles, encompassing 76 patients with post-bariatric ITGF, showed that the clinical outcome depends on the initial presentation, timing of the diagnosis in relation to symptom onset, and prompt and effective treatment. Any septic or unstable patient must undergo urgent surgical intervention, while stable patients might tolerate a step-up approach and watchful waiting for nonsurgical treatment. Among those who undergo surgery, treatment failure and the mortality rate are substantially high. Contingent upon a prompt management strategy, patients with postbariatric ITGF can generally have a favorable outcome in the long term. 相似文献
7.
Nazir Ahmad Tahmina Ruhi 《Indian journal of otolaryngology and head and neck surgery》1994,46(2):96-100
BAEPS are coming up as an important investigatory tool in the hands of present clinicians and have a diagnostic and prognostic significance. The present study was carried on 25 patients. BAEPS were recorded at the time of admission and analysed. Absent BAEPS were associated with high mortality. Abnormal BAEPS were seen in infective and CVA group. Followup BAEPS showed no change in those patients who died. 相似文献
8.
Osteoblast-derived factors induce androgen-independent proliferation and expression of prostate-specific antigen in human prostate cancer cells. 总被引:1,自引:0,他引:1
9.
Silver nanoparticles production by two soil isolated bacteria,Bacillus thuringiensis and Enterobacter cloacae,and assessment of their cytotoxicity and wound healing effect in rats 下载免费PDF全文
Parastoo Pourali PhD Nasrin Razavian Zadeh MD Behrooz Yahyaei PhD 《Wound repair and regeneration》2016,24(5):860-869
Production of silver nanoparticles by Bacillus thuringiensis and Enterobacter cloacae was performed and confirmed through UV–visible spectrophotometry, transmission electron microscopy (TEM), and x‐ray diffraction (XRD) analyses. The 3‐(4,5‐dimethylthiazol‐2‐yl)?2,5‐diphenyltetrazolium bromide (MTT) assay using mouse fibroblast cell line NIH‐3T3 D4 was carried out and IC50s of AgNPs were obtained. The nontoxic dose of each AgNPs solution was selected for wound healing assay. Thirty‐two rats were divided into four groups; two were used as the controls and two were treated by AgNPs that were produced by two bacterial strains. Results revealed that the produced AgNPs were amorphous, spherical in shapes, and had sizes under 100 nm. Histological analysis showed that AgNPs had better wound healing efficacy than the control groups. In conclusion, when the biologically produced AgNPs were used in vivo, they induced the epithelization, formation of the collagen bundles and fibroplasia and reduced the duration of completion of the epithelization and the angiogenesis. 相似文献
10.
Maryam Shahrabi-Farahani Ebrahim Karimi Leila Vazifeh Mostaan Sadaf Saba Nasrin Yazdani Mahsa M.Amoli 《Pathology, research and practice》2018,214(1):130-133
Detection of Epstein-Barr virus in oral squamous cell carcinoma suggests its involvement in the carcinogenesis of oral cavity. But, there are few studies on the incidence of EBV genome in squamous cell carcinomas at specific locations in the oral cavity like tongue and with different tumor progression. In this study the presence of EBV genome in tongue Squamous Cell Carcinoma (TSCC) in Iranian patients were investigated. Accordingly, a total of 94 cases with TSCC were firstly analyzed for the presence of viral genome through Nested PCR. Patients were divided into different groups based on their gender and the size, nodal involvement, grade and stage of their tumor. Results showed the presence of EBV genome in 72.3% of TSCCs with no significant difference between two genders, although slightly higher in females. Interestingly, PCR products of EBV genome showed a statistically significant higher distribution in TSCCs at IVa stage (p = 0.04), while a considerable low involvement of EBV genome was seen in T1-sized tumors. The result of this study further emphasizes the role of EBV in oral SCCs – mainly at tongue. This is the first investigation to clarify the association between EBV genome and different tumor size and stage in TSCCs; however, more studies in different regions and larger populations should be performed to be able to draw a firmed conclusion. 相似文献