全文获取类型
收费全文 | 35篇 |
免费 | 2篇 |
专业分类
儿科学 | 1篇 |
基础医学 | 8篇 |
临床医学 | 5篇 |
内科学 | 8篇 |
皮肤病学 | 2篇 |
外科学 | 2篇 |
综合类 | 1篇 |
预防医学 | 3篇 |
药学 | 2篇 |
肿瘤学 | 5篇 |
出版年
2017年 | 1篇 |
2015年 | 1篇 |
2012年 | 1篇 |
2011年 | 2篇 |
2010年 | 1篇 |
2009年 | 1篇 |
2007年 | 1篇 |
2006年 | 1篇 |
2004年 | 1篇 |
2002年 | 1篇 |
1999年 | 1篇 |
1997年 | 4篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1965年 | 1篇 |
1954年 | 1篇 |
1949年 | 4篇 |
排序方式: 共有37条查询结果,搜索用时 15 毫秒
1.
2.
R. KESSLER S. LEIBHAMMER O. LAUE A. SACHINIDIS W. SIFFERT H. HOLS H. VETTER & R. DÜSING 《European journal of clinical investigation》1997,27(7):558-565
The effect of acute expansion of the extracellular fluid volume (ECV) with isotonic (0.9%) saline on the activity of the lymphocyte Na+/H+ antiport (NHE) was studied in a total of 18 healthy volunteers. Saline was infused at a constant rate so that 4 mmol kg?1 b.w. was administered over 2 h. NHE activity was measured by quantifying cytosolic pH (pHi) recovery following acidification of the cells with propionic acid and by pH clamping at various pHi values between 7.2 and 5.8 using nigericin. Both methods demonstrate NHE activation associated with intravenous saline infusion, the kinetic difference being a marked decrease in the Hill coefficient n from 3.28 ± 0.21 (SEM) to 2.22 ± 0.11 in the absence of changes in baseline pHi (7.14 ± 0.02 vs. 7.08 ± 0.02; P = 0.15), Vmax (42.8 ± 2.7 vs. 48.1 ± 2.8 mmol L?1 min?1; P = 0.08) and pK (6.32 ± 0.04 vs. 6.35 ± 0.02). NHE activation was associated with significant decreases in serum chloride (P = 0.016), calcium (P = 0.008), total cholesterol (P = 0.008), low-density lipoproteins (P = 0.016) and high-density lipoproteins (P = 0.008). Moreover, saline infusion induced extracellular acidification with a decrease in pH from 7.39 ± 0.01 to 7.37 ± 0.01 (P = 0.016), HCO3? from 23.3 ± 0.43 mmol L?1 to 21.3 ± 0.25 mmol L?1 (P = 0.008) and base excess from ?1.03 ± 0.38 mmol L?1 to ?3.00 ± 0.31 mmol L?1 (P = 0.008). Our results show for the first time that acute ECV expansion with isotonic saline is followed by an activation of the lymphocyte NHE. The underlying mechanism(s) remain to be investigated. However, the demonstration in our study of marked changes in acid–base balance induced by acute saline points to a possible inter-relationship of antiporter activation and extracellular acidification. 相似文献
3.
Use of spiral and non-spiral computed tomography arterial portography in the detection of potentially malignant liver masses 总被引:2,自引:0,他引:2
NOEL YOUNG TOM SING KAI PING WONG MICHAEL HOLLANDS NOEL TAIT 《Journal of gastroenterology and hepatology》1997,12(5):385-391
The present study assesses the usefulness of computed tomography (CT) arterial portography (CTAP) in detecting and defining the number and anatomy of potentially malignant liver lesions. One hundred and one adults studied in 1993 and 1994 were retrospectively reviewed, including patients with primary or secondary tumours for possible resection and patients with non-hepatic malignancies in whom the detection of liver metastases would preclude surgery. Twenty-three patients underwent non-spiral CT studies and 78 had studies on a spiral unit, with 22 of these having single phase and 56 having dual phase studies to overcome artefact problems. The relationship between lesion size and detection sensitivity is critical. On non-spiral studies, the overall lesion detection sensitivity and positive predictive value was 69 and 90%, respectively. Detection sensitivity was 100 and 20% for lesions > 1 cm and < 1 cm, respectively. On single phase spiral CTAP the overall detection sensitivity and positive predictive value was 80 and 66%, respectively. Detection sensitivity for lesions > 1 cm and < 1 cm was 100 and 0%, respectively. On dual phase spiral CTAP the overall detection sensitivity and positive predictive value was 76 and 71%, respectively. For lesions > 1 cm and < 1 cm the sensitivity was 81 and 55%, respectively. Eighteen patients with non-hepatic malignancies with unsuspected metastatic spread did not proceed to major surgery because of liver metastases detected on CTAP. Perfusion artefacts occurred in 30 and 64% of non-spiral and of initial portal venous spiral CTAP studies, respectively. By using the double-phase technique, these artefacts were substantially diminished. In conclusion, CTAP is a valuable tool for assessing the presence, site and size of possible liver tumours and confers a benefit even when previous ultrasound and conventional CT have already been used. In addition, CTAP has a lower limit of useful resolution of approximately 1 cm. Perfusion artefacts can be reduced by a dual phase protocol. 相似文献
4.
阻塞性黄疸患者围手术期易感性明显高于非黄疸者,发病原因尚不完全清楚。本文研究了阻塞性黄疸大鼠脾脏淋巴细胞白细胞介素2(IL-2)生成能力及抑制性T淋巴细胞(Ts)功能的变化以及消炎痛的作用。结果表明。胆管结扎大鼠脾脏淋巴细胞IL-2生成明显下降,Ts细胞活性明显增强;消炎痛治疗使阻塞性黄疸大鼠脾脏淋巴细胞IL-2生成能力增强和TS细胞活性下降。提示阻塞性黄疸宿主免疫功能异常,可能是其围手术期易感性增高的原因之一,消炎痛有可能成为改善阻塞性黄疽病人免疫功能,降低感染易感性的有价值药物之一。 相似文献
5.
6.
目的:探讨护理干预对急性淋巴细胞白血病应用大剂量抗代谢药物甲氨蝶呤(MTX)、阿糖胞苷(Ara-C)所致口腔黏膜炎的影响。方法:选择2009~2012年我院血液科住院的采用Hyper-CVAD/MA方案及HD-MTX方案化疗的80例患者,在化疗期间对口腔黏膜炎的发生采取了护理干预,按照随机对照表法抽签随机分为实验组和对照组,实验组40例,给予2.5%碳酸氢钠生理盐水溶液漱口加冰果冻含化;对照组40例,给予2.5%碳酸氢钠生理盐水溶液漱口,两组患者均给予常规口腔护理。结果:实验组口腔溃疡发生率明显低于对照组,差异有显著性(P相似文献
7.
We addressed the question: Is there evidence that allelic variation in a single unmeasured gene that has a large effect on maximal activity of erythrocyte sodium-lithium countertransport (Na-Li CNT) also has pleiotropic effects on variation in plasma triglyceride levels? Complex segregation analysis models that included plasma triglyceride levels as a covariate were considered as explanations for interindividual variation in Na-Li CNT. A sample of 711 healthy adults from 254 pedigrees enrolled in the Rochester Family Heart Study was selected for this study. The majority of the pedigrees supported the hypothesis that variations in a single unmeasured non-transmitted environmental factor have large effects on the Na-Li CNT distribution. Only gender-specific first-order covariate parameters were necessary in the complex segregation models suggesting that the form of the relationship between Na-Li CNT and plasma triglyceride level was not influenced by variation in the inferred environmental factor with large effects. Stratification of the sample by this inferred environmental factor resulted in three classes of individuals with significant differences in the distributions of coronary heart disease risk factor traits, as well as interindividual variation in both Na-Li CNT and plasma triglyceride levels. These results, along with other observations from the Rochester Family Heart Study sample, emphasize the complex and multifactorial nature of the causes of interindividual variation in Na-Li CNT. Our study further suggests that new research strategies are needed for studying the relationships between genetic and environmental variation and variation in quantitative traits such as Na-Li CNT that have been identified as risk factors for hypertension. 相似文献
8.
9.
Clinical application of prognostic factors for patients with organic causes of erectile dysfunction on 100 mg of sildenafil citrate 总被引:1,自引:0,他引:1
SING JOO CHIA KAMALAKANNAN RAMESH ARUL EARNEST 《International journal of urology》2004,11(12):1104-1109
OBJECTIVES: There are still no clinical predictive factors to determine the response rate of erectile dysfunction (ED) patients to sildenefil citrate. The aim of the present study is to evaluate and stratify the risk factors and attempted to determine the prognostic factors in clinical practice to predict the response rate. This is important in improving cost effectiveness and avoiding side-effects. MATERIAL AND METHODS: This is an open label prospective study including patients attending the andrology clinic in Tan Tock Seng Hospital, Singapore, over 2 years. The patients were evaluated and investigated for possible underlying causes and ED severity was assessed by five-items of the International Index of Erectile Function questionnaire (IIEF-5), together with the duration, degree and rigidity of erection. Psychogenic causes were excluded with a minimal follow up of 6 months. All patients were placed on 100 mg of sildenafil citrate and were reassessed at the end of 6 months. Logistic regression with univariate and multivariate was used as the method of statistical analysis. RESULTS: A total of 232 patients were in the cohort. The overall response rate was 43%, with the best response rate in veno-occlusive cases and the worst responses from neurogenic causes. Age, smoking, diabetes mellitus, hypertension, hyperlipidemia, pretreatment IIEF-5 score, interval to achieve erection and duration of erection were significant in univariate analysis, but only age, smoking and IIEF-5 score were significant in multivariate analysis. With a combination of these factors, a table was formed to determine the possible response rate in clinical practice. This will assist physicians in selecting patients with potentially favorable responses and avoid side-effects and an unnecessary wastage of time and cost. CONCLUSION: Possible factors could be determined and used clinically to predict the response rate to sildenafil citrate. 相似文献
10.