全文获取类型
收费全文 | 1638篇 |
免费 | 160篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 43篇 |
妇产科学 | 19篇 |
基础医学 | 181篇 |
口腔科学 | 37篇 |
临床医学 | 139篇 |
内科学 | 402篇 |
皮肤病学 | 8篇 |
神经病学 | 110篇 |
特种医学 | 200篇 |
外科学 | 219篇 |
综合类 | 23篇 |
一般理论 | 1篇 |
预防医学 | 184篇 |
眼科学 | 14篇 |
药学 | 134篇 |
中国医学 | 1篇 |
肿瘤学 | 78篇 |
出版年
2021年 | 23篇 |
2019年 | 15篇 |
2018年 | 28篇 |
2017年 | 25篇 |
2016年 | 21篇 |
2015年 | 27篇 |
2014年 | 47篇 |
2013年 | 57篇 |
2012年 | 61篇 |
2011年 | 68篇 |
2010年 | 36篇 |
2009年 | 35篇 |
2008年 | 56篇 |
2007年 | 64篇 |
2006年 | 57篇 |
2005年 | 50篇 |
2004年 | 46篇 |
2003年 | 42篇 |
2002年 | 43篇 |
2001年 | 38篇 |
2000年 | 42篇 |
1999年 | 46篇 |
1998年 | 49篇 |
1997年 | 28篇 |
1996年 | 32篇 |
1995年 | 23篇 |
1994年 | 33篇 |
1993年 | 22篇 |
1992年 | 33篇 |
1991年 | 37篇 |
1990年 | 45篇 |
1989年 | 57篇 |
1988年 | 58篇 |
1987年 | 40篇 |
1986年 | 54篇 |
1985年 | 39篇 |
1984年 | 28篇 |
1983年 | 21篇 |
1982年 | 24篇 |
1981年 | 15篇 |
1980年 | 20篇 |
1979年 | 17篇 |
1977年 | 17篇 |
1976年 | 13篇 |
1974年 | 15篇 |
1973年 | 15篇 |
1972年 | 15篇 |
1970年 | 13篇 |
1969年 | 15篇 |
1966年 | 13篇 |
排序方式: 共有1818条查询结果,搜索用时 15 毫秒
1.
2.
3.
H. William Scott Jr. M.D. Craig R. Sussman M.D. David L. Page M.D. Norman W. Thompson M.D. Milton D. Gross M.D. Ricardo Lloyd M.D. 《World journal of surgery》1986,10(4):646-652
Since the syndrome of primary hyperaldosteronism was described by Jerome Conn in 1955, over 300 patients with this disorder have been identified in the medical centers of Vanderbilt University and the University of Michigan. The most frequent cause of this endocrinopathy has been a solitary adenoma of the adrenal cortex (72%); bilateral adrenocortical hyperplasia has been the cause of primary hyperaldosteronism in 27% of cases; less frequently, the cause has been multiple and/or bilateral adenomas (1%). During the last 4 years in these 2 medical centers, we have encountered 3 patients who have had biochemically proven primary hyperaldosteronism due to adrenocortical carcinoma. Each of these unusual cases is summarized with review of the recent literature.
Presented at the International Association of Endocrine Surgeons in Paris, September 1985. 相似文献
Resumen Desde la descripción del síndrome de hiperaldosteronismo primario por Jeremo Conn en 1955, más de 300 pacientes con esta entidad han sido identificados en nuestros 2 centros médicos, la Universidad de Vanderbilt (Nashville) y la Universidad de Michigan (Ann Arbor). La causa más frecuente de esta endocrinopatía ha sido el adenoma solitario de la corteza suprarrenal (72%); la hiperplasia adrenocortical bilateral ha sido la causa del hiperaldosteronismo primario en 27% de los casos; con menor frecuencia se han presentado los adenomas multiples y/o bilaterales (1%). En los 4 últimos años hemos encontrado 3 pacientes con hiperaldosteronismo primario comprobado bioquímicamente producido por carcinoma adrenocortical. Se presenta cada uno de estos casos poco usuales junto con una revisión de la literatura reciente.
Résumé Depuis que le syndrome d'hyperaldostéronisme primitif a été décrit par Jerôme Conn en 1955 plus de 300 sujets qui en étaient victimes ont été identifiés à la Vanderbilt University de Nashville et à l'University of Michigan de Ann Arbor. La cause la plus fréquente de cette endocrinopathie répond à un adénome solitaire de la cortico-surrénale (72%) alors que l'hyperplasie corticale des 2 surrénales est plus rarement à son origine (27%), les adénomes multiples et/ou bilatéraux étant rarissimes (1%). Au cours des 4 dernières années 3 cas d'hyperaldosteronisme dû à un cancer de la cortico-surrénale ont été observés dans les 2 centres. Chacun de ces cas exceptionnels est exposé cependant que la littérature récente concernant l'hyperalderosteronisme est analysée.
Presented at the International Association of Endocrine Surgeons in Paris, September 1985. 相似文献
4.
Release of soluble transferrin receptor from the surface of human leukemic HL60 cells 总被引:2,自引:0,他引:2
Information regarding transferrin (Tf) receptor degradation is largely incomplete. HL60 cells were shown to release to their growth medium a Tf-binding protein which could be immunoprecipitated by anti-Tf receptor monoclonal antibodies (MoAbs) B3/25 and OKT9. Soluble Tf receptor was detected in the medium within one hour of replating of cells, and its release was inhibited at 4 degrees C. The affinity of Tf for the soluble receptor released by cells (kd = 2.3 x 10(-10) mol/L) was slightly lower than its affinity for the detergent-solubilized cellular receptor (kd = 1.2 x 10(-10) mol/L). 125I-Tf internalized and released by cells subsequently bound to Tf receptor released by the same cells, and soluble Tf receptor in the conditioned medium (CM) inhibited 125I-Tf binding to intact cells. The soluble Tf receptor isolated from the CM was smaller (78,000 daltons) than the cell surface receptor (94,000 daltons) when analyzed by gel electrophoresis under reducing conditions. Isolated cell membranes readily released soluble receptor; however, this release could be blocked by protease inhibitors. The soluble Tf receptor may represent the extracytoplasmic domain of the cellular Tf receptor released from the surface of HL60 cells through proteolytic cleavage by a membrane-based protease. 相似文献
5.
Reversal of fulminant hepatic failure using an extracorporeal liver assist device. 总被引:20,自引:0,他引:20
N L Sussman M G Chong T Koussayer D E He T A Shang H H Whisennand J H Kelly 《Hepatology (Baltimore, Md.)》1992,16(1):60-65
Liver transplantation is currently the only effective therapy for patients with fulminant hepatic failure. The availability of an artificial liver could bridge these patients through the relatively brief crisis period and allow their own livers to regenerate, providing a more favorable outcome and sparing the trauma and expense of transplant. We have developed a device consisting of a highly differentiated human liver cell line cultured in a hollow fiber cartridge. This device is capable of supporting dogs with acetaminophen-induced fulminant hepatic failure for a period long enough for their own livers to resume function. Even though liver function tests such as albumin and prothrombin time became extremely abnormal during the course of the experiment, the dogs did not become encephalopathic. Two of the three treated animals recovered sufficient liver function after 42 to 48 hr of treatment that they could be disconnected from the device, and they survived the experiment. Histological results and serum ALT levels suggest that the device affected the course of the disease in two animals, allowing recovery of hepatocytes that would otherwise have lysed. In the third animal, regenerative nodules demonstrated that, even in the presence of severe liver injury, the device was capable of supporting total liver function. 相似文献
6.
We reviewed data from 48 patients after anterior temporal lobe resection for medically intractable epilepsy. All had ictal electro-encephalographic (EEG) evidence of unilateral temporal lobe onset. Depth electrodes were used in 19 patients. Successful surgical outcome correlated significantly with factors that suggested a temporal lobe focus, particularly in the interictal scalp EEG. The most successful outcome occurred in patients with well-localized unilateral interictal temporal spikes (100% improved). The group with well-localized bilateral temporal spikes also did well (76% improved). Patients with extratemporal spread of the interictal spike on scalp EEG, either unilaterally or bilaterally, did less well. Only one third improved, despite extensive extracranial and intracranial monitoring, when indicated. The interictal scalp EEG may be the only EEG necessary for the presurgical evaluation of selected patients with intractable temporal lobe epilepsy. 相似文献
7.
8.
9.
Sanjana VM; Johnston PA; Robertson CR; Jamison RL 《The American journal of physiology》1976,231(2):313-318
10.
Localization of a gene for otosclerosis to chromosome 15q25-q26 总被引:5,自引:0,他引:5
Tomek MS; Brown MR; Mani SR; Ramesh A; Srisailapathy CR; Coucke P; Zbar RI; Bell AM; McGuirt WT; Fukushima K; Willems PJ; Van Camp G; Smith RJ 《Human molecular genetics》1998,7(2):285-290
Among white adults otosclerosis is the single most common cause of hearing
impairment. Although the genetics of this disease are controversial, the
majority of studies indicate autosomal dominant inheritance with reduced
penetrance. We studied a large multi- generational family in which
otosclerosis has been inherited in an autosomal dominant pattern. Five of16
affected persons have surgically confirmed otosclerosis; the remaining nine
have a conductive hearing loss but have not undergone corrective surgery.
To locate the disease- causing gene we completed genetic linkage analysis
using short tandem repeat polymorphisms (STRPs) distributed over the entire
genome. Multipoint linkage analysis showed that only one genomic region, on
chromosome 15q, generated a lod score >2.0. Additional STRPs were typed
in this area, resulting in a lod score of 3.4. STRPs FES (centromeric) and
D15S657 (telomeric) flank the 14. 5 cM region that contains an otosclerosis
gene.
相似文献