全文获取类型
收费全文 | 9080篇 |
免费 | 716篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 162篇 |
妇产科学 | 282篇 |
基础医学 | 1046篇 |
口腔科学 | 118篇 |
临床医学 | 926篇 |
内科学 | 2221篇 |
皮肤病学 | 203篇 |
神经病学 | 900篇 |
特种医学 | 282篇 |
外科学 | 1261篇 |
综合类 | 153篇 |
一般理论 | 2篇 |
预防医学 | 779篇 |
眼科学 | 359篇 |
药学 | 597篇 |
中国医学 | 3篇 |
肿瘤学 | 462篇 |
出版年
2021年 | 143篇 |
2020年 | 68篇 |
2019年 | 156篇 |
2018年 | 169篇 |
2017年 | 89篇 |
2016年 | 115篇 |
2015年 | 123篇 |
2014年 | 226篇 |
2013年 | 313篇 |
2012年 | 418篇 |
2011年 | 455篇 |
2010年 | 269篇 |
2009年 | 213篇 |
2008年 | 337篇 |
2007年 | 451篇 |
2006年 | 391篇 |
2005年 | 382篇 |
2004年 | 367篇 |
2003年 | 344篇 |
2002年 | 327篇 |
2001年 | 305篇 |
2000年 | 325篇 |
1999年 | 260篇 |
1998年 | 113篇 |
1997年 | 81篇 |
1996年 | 80篇 |
1995年 | 69篇 |
1994年 | 78篇 |
1993年 | 67篇 |
1992年 | 161篇 |
1991年 | 159篇 |
1990年 | 210篇 |
1989年 | 163篇 |
1988年 | 181篇 |
1987年 | 161篇 |
1986年 | 184篇 |
1985年 | 158篇 |
1984年 | 106篇 |
1983年 | 108篇 |
1982年 | 72篇 |
1980年 | 74篇 |
1979年 | 138篇 |
1978年 | 90篇 |
1977年 | 82篇 |
1976年 | 75篇 |
1975年 | 66篇 |
1974年 | 64篇 |
1973年 | 69篇 |
1972年 | 75篇 |
1971年 | 66篇 |
排序方式: 共有9827条查询结果,搜索用时 15 毫秒
1.
Heather M Arthur Christine Patterson James A Stone 《European journal of cardiovascular prevention and rehabilitation》2006,13(1):3-9
BACKGROUND: Presently, complementary and alternative medicine, including both therapies and herbal/oral supplements, is used globally. Few studies have examined the use of specific therapies, separate from herbal/oral supplements, in cardiac rehabilitation. This paper presents a systematic evaluation of current research evidence related to use of specific complementary and alternative medicine therapies in secondary prevention of cardiovascular disease, with a view to making recommendations for cardiac rehabilitation. DESIGN AND METHODS: A literature search was conducted using complementary and alternative medicine websites, Medline, Allied and Complementary Medicine, CINAHL, Cochrane databases, EMBASE, SportDiscus, Clinical Evidence, and Evidence-Based Practice to locate research-based scientific evidence related to the use of complementary and alternative medicine in cardiac rehabilitation. Search keywords included heart, cardiac, cardiovascular, coronary, myocardial and rehabilitation, combined with particular therapies. Herbal/oral supplements were not included in this evaluation. RESULTS: Some complementary and alternative medicine therapies may be useful to patients by themselves or coupled with traditional cardiac rehabilitation. Tai chi, as a complement to existing exercise interventions, can be utilized for low and intermediate risk patients. transcendental meditation may be used as a stress reduction technique. There was insufficient evidence found for the use of acupuncture or chelation therapy in cardiac rehabilitation or secondary prevention. CONCLUSIONS: Some complementary and alternative medicine therapies hold promise for patients in cardiac rehabilitation. Further research is essential, however, in all areas of complementary and alternative medicine to confirm its usefulness as an adjunct to cardiac rehabilitation. 相似文献
2.
Peter Stone MD FRNZCOG FRCOG David Cook FRNZCOG MRCOG John Hutton PhD FRNZCOG FRCOG Gordon Purdie BSc Henry Murray MD FRNZCOG MRCOG Lauren Harcourt MPP BA 《The Australian & New Zealand journal of obstetrics & gynaecology》1995,35(1):32-37
Summary: This is the first report of the largest study of blood pressure measurement in pregnancy in a New Zealand population using standardized definitions and methodology. Over 3,800 women who delivered in an 8-month period in the Wellington region were included in the study. Blood pressure measurement and the presence of oedema and proteinuria were recorded from booking until delivery and in the puerperium. Only 2.7% of women were unable to be contacted after delivery for details on outcomes. The results established normal ranges for blood pressure throughout pregnancy. The data show that Mood pressure greater than 140/90 until 35 weeks' gestation is outside 2 standard deviations at all gestations and justifies using these measurements as the definition of hypertension in pregnancy. The fall in blood pressure in the 2nd trimester was less than 1 mm Ffg per week in both the systolic and diastolic pressures. This fall was smaller than previously recorded in other studies. Gestational hypertension was the commonest blood pressure abnormality occurring in 15.2% of the population. This represented 69% of the pregnant women with a hypertensive disorder. The overall incidence of both gestational hypertension and preeclampsia was 18.5% which is higher than reported in other parts of the world. In this study obesity was significantly associated with hypertensive disorders in pregnancy. An arm circumference of >33 cm, one of the measurements of obesity, was found in 6.8% of the study population. Even after the effect of arm circumference was taken into account, hypertensive disorders were also more common in Pacific Island women. Ankle oedema was significantly associated with the development of both gestational hypertension and preeclampsia but the incidence of oedema was noted in only 11.9% of the subjects. 相似文献
3.
Preservation of the breast with a good or excellent cosmetic appearance is achievable in most patients. Careful attention to the details of surgical technique allows these procedures to be carried out easily and comfortably for the patient and the surgeon alike. 相似文献
4.
Previous studies have shown that stimulation of adrenergic receptors in the brain increases the expression of the immediate early gene (IEG), c-fos, in vivo (Mol. Brain Res., 6(1989) 39-45). The present study was undertaken to determine whether this also holds for other IEGs which have been shown to be activated in brain cell culture by adrenergic agonists. Both yohimbine injection and stressful stimulation, two treatments causing brain norepinephrine (NE) release, were found to cause a parallel, transient activation of at least 5 IEGs (c-fos, nur77, tis-7, zif-268 and tis-21) in the rat cortex. Genes that are not immediate early (beta-actin, NGF and HSP70) were found not to be affected in the interval used (6 h). The responses were mediated predominantly by beta-adrenoceptors with some contribution from alpha 1 receptors. The parallel activation of multiple genes by noradrenergic receptors may enable the coding of different biochemical responses to the activation of different receptors. 相似文献
5.
6.
Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts. 总被引:3,自引:0,他引:3
Yinzhi Zhao Song Gao Iih-Nan Chou Paul Toselli Phillip Stone Wande Li 《Toxicological sciences》2006,90(2):478-489
Copper (Cu)-dependent lysyl oxidase (LO) catalyzes crosslinking of collagen and elastin stabilizing the extracellular matrix (ECM). Chronic inhalation of cadmium (Cd), a toxic metal, induces emphysema. To probe mechanisms of Cd injury to the lung, we developed Cd-resistant (CdR) cells from rat fetal lung fibroblasts (RFL6) by chronic exposure to CdCl(2) from 1 to 40 microM and further examined their expressions of LO, LO substrates, and Cu-scavenging thiols. Levels of cellular thiols, metallothionein, and glutathione in CdR cells were elevated to 13.0- and 3.2-fold of parental controls, respectively, whereas LO mRNA and protein levels were markedly reduced in these cells, with catalytic activity declining to only 16% of the parental control. A conspicuous 52 kDa species rather then the normal 50 kDa proenzyme appeared in the CdR cell extract but not in the conditioned medium, which was codistributed with the endoplasmic reticulum marker [DiOC5(3)] within the cell, implying the Cd-induced 52 kDa species as a product of an abnormal LO-processing defect in secretion. Addition of Cu into CdR cell cultures enhanced the expression of LO mRNA, protein and catalytic activities reflecting limitation of Cu bioavailability for LO in these cells. With inhibition of LO, CdR cells also displayed downregulation of collagen and elastin, substrates of LO. Restoration of collagen synthesis by exposure of CdR cells to purified LO or Cu suggests that inhibition of LO and limitation of Cu cofactor by Cd, as key phenotype changes, accelerated collagen and elastin damage, a critical event pertinent to emphysema pathogenesis. 相似文献
7.
8.
Handcuff neuropathies 总被引:1,自引:0,他引:1
Compressive neuropathy due to tight application of handcuffs occurred in 5 patients. The superficial radial nerve was affected in 8 hands and the median nerve in two. Neurologic deficits persisted as long as 3 years after handcuffing. Nerve conduction studies helped to exclude malingering and other diagnoses. All patients had been intoxicated when handcuffed or had been arrested with force. The handcuff mechanism, which allows accidental overtightening after application, is an unrecognized factor in these neuropathies. 相似文献
9.
D H Char J R Castro J M Quivey T L Phillips A R Irvine R D Stone S Kroll 《Ophthalmology》1989,96(12):1708-1715
The optimum radiation therapy for uveal melanoma is uncertain. Both helium ion irradiation and 125I brachytherapy have been used to treat this neoplasm. This investigation analyzed the control and complication rates of uveal melanomas treated with helium ions of 125I plaques. In both a retrospective and a prospective dynamically balanced study, the control rates appeared to be similar. There were more posterior segment complications after 125I plaques and more anterior segment complications, including neovascular glaucoma, after helium ion irradiation. The follow-up period is too short to draw definitive conclusions on the radiation complications. Overall, approximately 89% of eyes were retained and less than 4% of treated eyes were removed because of failure to control the tumor. 相似文献
10.
Difficulties with self-injection, including inabillity to self-inject, are common for individuals taking home-administered injectable medications. In relapsing-remitting multiple sclerosis (MS), all of the currently available disease-modifying medications are injectables marketed for self-injection. Problems with self-injection pose a barrier to treatment adherence for many patients. Clinicians at the University of California, San Francisco (UCSF) Multiple Sclerosis Center have developed a number of strategies to help patients who experience anxiety associated with self-injection. These strategies have been empirically tested and found to be effective and easily implemented by mental health professionals and nurses. This article offers case examples and discussion of the principles of the techniques developed at UCSF to remediate patients' difficulties with self-injection. Nurses are most often the healthcare providers responsible for training MS patients in self-injection and monitoring their compliance. Nurses who are familiar with these tools have the opportunity to have a significant positive impact on patient comfort, confidence, and, ultimately, successful long-term adherence to disease-modifying medications. 相似文献