全文获取类型
收费全文 | 3746篇 |
免费 | 225篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 126篇 |
妇产科学 | 138篇 |
基础医学 | 423篇 |
口腔科学 | 125篇 |
临床医学 | 420篇 |
内科学 | 764篇 |
皮肤病学 | 55篇 |
神经病学 | 295篇 |
特种医学 | 135篇 |
外科学 | 489篇 |
综合类 | 60篇 |
一般理论 | 4篇 |
预防医学 | 470篇 |
眼科学 | 30篇 |
药学 | 208篇 |
中国医学 | 2篇 |
肿瘤学 | 224篇 |
出版年
2022年 | 37篇 |
2021年 | 68篇 |
2020年 | 28篇 |
2019年 | 45篇 |
2018年 | 56篇 |
2017年 | 41篇 |
2016年 | 57篇 |
2015年 | 68篇 |
2014年 | 100篇 |
2013年 | 128篇 |
2012年 | 182篇 |
2011年 | 178篇 |
2010年 | 117篇 |
2009年 | 122篇 |
2008年 | 160篇 |
2007年 | 192篇 |
2006年 | 186篇 |
2005年 | 194篇 |
2004年 | 178篇 |
2003年 | 148篇 |
2002年 | 145篇 |
2001年 | 104篇 |
2000年 | 89篇 |
1999年 | 102篇 |
1998年 | 27篇 |
1997年 | 39篇 |
1996年 | 40篇 |
1995年 | 43篇 |
1994年 | 28篇 |
1992年 | 66篇 |
1991年 | 61篇 |
1990年 | 50篇 |
1989年 | 66篇 |
1988年 | 50篇 |
1987年 | 67篇 |
1986年 | 54篇 |
1985年 | 73篇 |
1984年 | 52篇 |
1983年 | 56篇 |
1981年 | 32篇 |
1980年 | 28篇 |
1979年 | 39篇 |
1978年 | 33篇 |
1977年 | 24篇 |
1976年 | 24篇 |
1975年 | 23篇 |
1974年 | 30篇 |
1973年 | 27篇 |
1972年 | 27篇 |
1969年 | 24篇 |
排序方式: 共有3987条查询结果,搜索用时 15 毫秒
1.
2.
Study DesignSystematic review.IntroductionContrast baths are used as an intervention in hand therapy, yet it is unclear which patients, if any, benefit from this intervention.Purpose of the StudyTo examine the nature and quality of the evidence regarding the use of contrast baths using a systematic review process.MethodsOf a total of 28 clinical research articles on contrast baths, from 1938 forward, ten met the inclusion criteria set by the authors.ResultsThese studies addressed the physiological changes of hot and cold on blood flow, intramuscular temperature, subcutaneous temperature, and the influence of room temperature and age. The subjects included normal/healthy volunteers and patients with a diagnosis of rheumatoid arthritis, diabetes, or foot/ankle injuries. The diversity of conditions, protocols, and outcomes limited the ability to make definitive conclusions on efficacy.ConclusionsThe contrast bath procedure may increase superficial blood flow and skin temperature, though the evidence on the impact on edema is conflicting. No relationship between physiologic effects and functional outcomes has been established.Level of Evidence: 2A 相似文献
3.
G. Bradley Schaefer James N. Thompson John B. Bodensteiner James M. McConnell William J. Kimberling Charles T. Gay William D. Dutton David C. Hutchings Stanton B. Gray 《Annals of neurology》1996,39(3):382-385
There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dys- genesis likely to be solely responsible for clinical autistic behaviors. 相似文献
4.
Endovascular stent implantation in patients with stenotic aortoarteriopathies: early and medium-term results. 总被引:1,自引:0,他引:1
Ernest S Siwik Stanton B Perry James E Lock 《Catheterization and cardiovascular interventions》2003,59(3):380-386
Data regarding stent implantation for stenotic aortoarteriopathy (SAA) are incomplete. We report on nine patients with this rare syndrome who underwent arterial stent implantation. Indications, results, and complications for patients with SAA were reviewed. Nine patients underwent 11 procedures. Twenty-two stents were implanted in the aorta or brachiocephalic vessels. Five patients had diffuse stenoses, three patients had middle aortic syndrome, and one patient had thoracic and abdominal coarctation. Associated diagnoses included Williams syndrome (2), neurofibromatosis (2), Takayasu's (1), and congenital rubella (1). Median gradient was 60 mm Hg (20-140 mm Hg). Poststent gradient was 15 mm Hg (0-60 mm Hg; P < 0.001). Additional stents were implanted in two patients and five underwent stent redilation. Two patients (22%) were found to have aneurysm formation. Stent implantation effectively provides gradient relief in SAA. Gradient reduction persists or is amenable to redilation. Importantly, however, uncomplicated stent implantation does not preclude aneurysm formation and may be more common than in traditional patient groups. 相似文献
5.
Role of interferon in lethality and lymphoid atrophy induced by Coxsackievirus B3 infection in mice.
M R Capobianchi D Matteucci A Giovannetti E Soldaini M Bendinelli J G Stanton F Dianzani 《Viral immunology》1991,4(2):103-110
To assess the importance of interferon (IFN) in the pathology of coxsackievirus B3 (CVB-3) infection, we evaluated both mortality rate and lymphoid involution in young adult BALB/C mice infected with lethal doses of the virus and treated either with anti-IFN antibody or with murine IFN-alpha/beta. Administration of antibody to IFN caused a profound worsening of the pathology and an increase in the mortality rate in infected animals. Treatment with murine IFN exerted a significant ameliorative effect on lethality when administered concomitantly with or soon after virus infection. The extent of this protection was correlated with the plasma levels of exogenous or endogenous IFN at 6 h postinfection, whereas no correlation with IFN titers was found later. The effects of IFN apparently were not directly mediated by antiviral effects, because at the times studied, no relation was found between IFN levels and virus titers, at least in the plasma of the infected animals. Lymphoid atrophy, assessed by measuring spleen weight, was only partially reversed by early IFN treatment. These data suggest that IFN production is critical during the early phases of infection, whereas it does not seem to play a significant protective role at later stages. 相似文献
6.
B Gerson 《Clinics in Laboratory Medicine》1987,7(3):669-686
Cyclosporine is a potent immunosuppressant with low myelotoxicity. It is approved for use to prevent rejection of kidney, liver, and heart transplants, and is being investigated for possible use for suppression of graft-versus-host disease in patients who have received bone marrow transplants. Although cyclosporine is generally thought of as an immunosuppressive agent for use in conjunction with transplantation, there are investigations underway that could result in wider applications. 相似文献
7.
8.
Amaya Gillespie Warren Stanton John B. Lowe Beth Hunter 《The Journal of school health》1995,65(10):432-437
ABSTRACT: This study obtained input from Australian student smokers approximately 15 years old, which may be useful in designing school-based smoking cessation programs. The sample was analyzed by previous quitting experience and intentions to quit. The order of preference for assistance options and incentives for quitting was similar across all groups: however, those who previously attempted to quit (previous quitters) and those who intended to quit (intenders) in the future were significantly more likely than non-quitters and non-intenders to find assistance options for quitting acceptable. The potential for saving money emerged as an important variable in convincing all groups of smokers not to smoke, and using personal willpower and cutting down slowly were identified as important in actual attempts to quit. The need for programs to be free and for friends to be supportive also was evident across all groups. 相似文献
9.
10.
Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised ICS 205-930 to 5-HT3 receptor sites in rat cortical membranes, possessing a pKi value of 7.0. In contrast, several other antipsychotic agents, including fluphenazine, alpha-flupenthixol, haloperidol, spiperone and (-)-sulpiride were essentially inactive. Clozapine also antagonised the 2-methyl 5-HT-induced depolarisation of the rat isolated superior cervical ganglion, a response known to be mediated via 5-HT3 receptors. Clozapine (0.1-1 microM) induced parallel displacements to the right of the dose-response curve to 2-methyl 5-HT in this tissue, possessing a pKb value of 7.3. These data suggest that the atypical antipsychotic profile of clozapine may be related, at least, in part to its ability to interact with central 5-HT3 receptor sites. 相似文献