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Jatuporn S Sangwatanaroj S Saengsiri AO Rattanapruks S Srimahachota S Uthayachalerm W Kuanoon W Panpakdee O Tangkijvanich P Tosukhowong P 《Clinical hemorheology and microcirculation》2003,29(3-4):429-436
The purpose of this study was to compare the short-term effects of an intensive lifestyle modification (ILM) program on lipid peroxidation and antioxidant systems in patients with coronary artery disease (CAD). Twenty-two patients in the control group continued to receive their conventional treatment with lipid-lowering drugs, whereas 22 patients in the experimental group were assigned to intensive lifestyle modification (ILM) without taking any lipid-lowering agent. The ILM program comprised dietary advice on low-fat diets, high antioxidants and high fiber intakes, yoga exercise, stress management and smoking cessation. After 4 months of intervention, patients in the experimental group revealed a statistically significant increase in plasma total antioxidants, plasma vitamin E and erythrocyte glutathione (GSH) compared to patients in the control group. There was no significant change in plasma malondialdehyde (MDA), a circulating product of lipid peroxidation, in either group. We concluded that the ILM program increased circulating antioxidants and reduced oxidative stress in patients with CAD. 相似文献
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Sunpaweravong S Sunpaweravong P 《Asian journal of surgery / Asian Surgical Association》2005,28(1):71-75
The biology of breast cancer is complex, and the increasing knowledge of its molecular biology is having a great impact on the clinical management of this serious condition. This review looks at new findings on the role of various critical genes, including BRCA1, BRCA2, HER2 and p53, in the development of breast cancer and their clinical implications. 相似文献
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Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma 总被引:6,自引:0,他引:6
Sunpaweravong P Sunpaweravong S Puttawibul P Mitarnun W Zeng C Barón AE Franklin W Said S Varella-Garcia M 《Journal of cancer research and clinical oncology》2005,131(2):111-119
Purpose To assess the status of EGFR, HER-2, and CCND1 at the gene and protein levels in esophageal squamous cell carcinoma.Methods Dual-color FISH assays were performed using DNA probes for EGFR/CEP 7, HER-2/CEP 17, and CCND1/CEP 11. The respective proteins, furthermore, was assessed in IHC assays and correlated with patient and tumor characteristics.Results From 55 ESCCs, 8 (15%) tumors showed gene amplification and 20 (36%) had gene overrepresentation (balanced gene and chromosome 7 polysomy) for EGFR. High-level protein expression was frequent (49%), positively correlated with gene copy numbers (kappa=0.4), and associated with well-differentiated histology (p=0.02). For HER-2, gene amplification was detected in a single tumor (2%) and protein overexpression was rare (9%). CCND1 gene was amplified in 23 (42%) tumors; likewise, CCND1 protein overexpression was common (58%) and prevailed in gene overrepresentation or amplification. Only 1 patient showed gene amplification for both EGFR and CCND1. Survival was not associated with EGFR or CCND1 gene/protein status, whereas negative patients for HER-2 protein had a better survival than positive patients (p=0.04).Conclusions Frequent overexpression and gene amplification of EGFR and CCND1 make these molecules and their pathways potential therapeutic targets for ESCC. In addition, EGFR and CCND1 appeared to be independently altered suggesting alternative mechanisms for pathway activation. Therapeutic agents targeting these molecules are urged to be tested in clinical trials and comprehensive biological analyses should be included to properly interpret the outcome. 相似文献
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Promphan W Sopontammarak S Pruekprasert P Kajornwattanakul W Kongpattanayothin A 《The Southeast Asian journal of tropical medicine and public health》2004,35(3):611-613
We report a 13-year-old boy who developed bradycardia and hypotension a day after recovery from dengue hemorrhagic fever. His electrocardiogram, during the bradycardia, showed a junctional rhythm with a rate of 50 beats/minute. This is the first reported case of sinus node dysfunction following dengue infection. 相似文献
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The aims of this article are to review the situation of occupational health and safety and to describe research priority in this field in Thailand. Thailand is one of newly industrialized countries in Southeast Asia. Approximately half of the working population is still in agriculture. The data from Thai Workmen's Compensation Fund showed that incidence rate of occupational injuries and diseases was 3-4% each year. Almost were occupational injuries from various accidents in workplaces. At least 3 relevant governmental agencies, including Ministry of Labour, Ministry of Public Health, and Ministry of Industry, are responsible in occupational health and safety in the country. Nowadays, those agencies collaborate and develop projects and activities to prevent and control of the problems. Because of lack of staff and other resources, research priority is needed and has been developed recently. The framework of research needed focuses on research and development such as how to improve occupational health and safety management at all levels, setting up and development of standard guidelines for health and environmental assessment, and implementation of suitable control measures in workplaces. Finally, improvement of research system in the country is essential to cope with new occupational health problems in the near future. 相似文献
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Aim: Calcitriol and alfacalcidol are used extensively for the treatment of secondary hyperparathyroidism. Unfortunately, there is limited published data comparing the efficacy and tolerability of both active vitamin D sterols. This study was undertaken to determine whether calcitriol provides a therapeutic advantage to alfacalcidol. Methods: This was a randomized, active controlled study. Patients with intact parathyroid hormone (iPTH) >32 pmol/L were randomized to receive orally calcitriol or alfacalcidol after each haemodialysis for up to 24 weeks. Reduction of PTH, changes of plasma albumin‐corrected calcium and phosphorus were analysed. The initial dose of alfacalcidol was twice that of calcitriol. Results: Sixteen patients were randomized into each group. At baseline, plasma albumin‐corrected calcium, phosphorus and PTH were no different between groups. At 24 weeks, PTH changes were ?50.8 ± 31.8% and ?49.4 ± 32.5% from the baseline in the calcitriol and alfacalcidol groups, respectively (P = 0.91). The patients who achieved target PTH of 16–32 pmol/L were 82% in the calcitriol and 67% in the alfacalcidol group (P = 0.44). Plasma albumin‐corrected calcium and phosphorus were not significantly different but showed trends toward gradually increasing from baseline in both groups (calcium, 6.0 ± 7.2% vs 10.9 ± 6.5% (P = 0.10); phosphorus, 13.0 ± 29.4% vs 16.7 ± 57.2% (P = 0.83) in calcitriol and alfacalcidol, respectively). The mean dose of calcitriol and alfacalcidol were 4.1 and 6.9 µg/week, respectively (P < 0.0001). Conclusion: Alfacalcidol can be used to control secondary hyperparathyroidism at doses of 1.5–2.0 times that of calcitriol. The two drugs are equally efficacious and lead to similar changes in calcium and phosphorus. 相似文献
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Durongpisitkul K Sangtawesin C Khongphatthanayopthin A Panamonta M Sopontammarak S Sittiwangkul R Pongpanich B 《Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand》2006,24(1):27-32
The incidence of Kawasaki disease (KD) in Thailand has never been studied before. We reviewed the data from the National Registry of Thai Children who had KD between 1998-2002 to evaluate the incidence of KD and cases resistant to treatment with intravenous immunoglobulin (IVIG). Resistance to IVIG was defined as remaining febrile at least 48 hours after initial IVIG therapy. There were 710 KD patients in the registry. The incidence of KD was from 2.14 to 3.43 cases per 100,000 children aged 0-5 years. During the acute phase 15.6% of 435 patients were considered as resistant cases. Resistant cases of KD in Thai children are quite common (15.6%) even after IVIG treatment. We found that patients who had high white blood cell counts (> 16,500 cells/mm3) had a higher likelihood of being resistant. 相似文献
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Jiamjarasrangsi W Lohsoonthorn V Lertmaharit S Sangwatanaroj S 《Diabetes research and clinical practice》2008,79(2):343-349
The purposes of this study were to determine the incidence rates and predictors of type 2 diabetes and impaired fasting plasma glucose (IFG) among the employees of a university hospital in Bangkok, Thailand. Totally 2370 and 1619 workers without diabetes and IFG at baseline, respectively, who were +35 years old were followed up during 2001-2005. Type 2 diabetes incidence rates (95% CI) were 13.6 (8.4-22.3) and 6.4 (4.5-9.1) per 1000 PYs, respectively, for men and women, while those of the IFG were 37.8 (26.3-54.4) and 23.6 (19.3-29.0) per 1000 PYs, respectively, for both genders. Baseline FBS predicted future IFG risk even at the levels as low as 63-70 mg/dl. The OR (95% CI) of IFG for those with baseline FPG of 63-70, 71-80, and >80 mg/dl-compared to those with baseline FPG < or =62 mg/dl-were 2.51 (1.12-5.64), 5.39 (2.51-11.56), and 8.30 (3.67-18.75), respectively. Future diabetes risk was observed only in those with baseline FPG of 96 mg/dl or higher, with the OR (95% CI) of 6.0 (2.29-15.75). In conclusion, baseline FPG even at the level as low as 63-70 mg/dl predicts future IFG risk among a hospital employee group in Thailand, while increased diabetes risk was found only in those at the FBS level of > or =96 mg/dl. 相似文献