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排序方式: 共有923条查询结果,搜索用时 22 毫秒
1.
Monica J. Carson Tina V. Bilousova Shweta S. Puntambekar Benoit Melchior Jonathan M. Doose Iryna M. Ethell 《Neurotherapeutics》2007,4(4):571-579
Microglial activation and macrophage infiltration into the CNS are common features of CNS autoimmune disease and of chronic
neurodegenerative diseases. Because these cells largely express an overlapping set of common macrophage markers, it has been
difficult to separate their respective contributions to disease onset and progression. This problem is further confounded
by the many types of macrophages that have been termed microglia. Several approaches, ranging from molecular profiling of
isolated cells to the generation of irradiation chimeric rodent models, are now beginning to generate rudimentary definitions
distinguishing the various types of microglia and macrophages found within the CNS and the potential roles that these cells
may play in health and disease. 相似文献
2.
Kerkar Shweta Shankar Arti Boynton-Jarrett Renee Harville Emily W. 《Maternal and child health journal》2021,25(3):479-486
Maternal and Child Health Journal - To investigate whether adverse childhood experiences are associated with miscarriage. The Gulf Resilience on Women’s Health Consortium recruited from... 相似文献
3.
Patel Shyam Kakouri Agni Chaudhary Shweta Knepper Paul A. Pfahler Nicholas M. Samples John Giovingo Michael 《Lasers in medical science》2021,36(3):605-609
Lasers in Medical Science - To evaluate the effect of various media and Iridex MicroPulse P3 (MP3) probe angles on the power output from the Cyclo G6 Glaucoma Laser (G6) System. A laser power meter... 相似文献
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Ruchi Goel Ruchita Sontakke Shalin Shah Vaibhav Nagpal Sushil Kumar Omeshwer Koli Shweta Ojha Swati Saini Deepanjali Arya 《Indian journal of ophthalmology》2022,70(11):3858
Purpose:To study the effect of wound size modulation on pre-existing astigmatism by on-axis placement of incision in manual small-incision cataract surgery (MSICS).Methods:In this prospective interventional study conducted at a tertiary care centre, 40 eyes of 40 consecutive senile cataract patients with 1.00–3.00 D corneal astigmatism were enrolled for the study. MSICS by modified Blumenthal’s technique was performed through 6.0, 6.5, and 7.0 mm on-axis incision in 1.0–1.49 D (group A), 1.50–1.99 D (group B), and 2.00–3.00 D (group C) astigmatism, respectively. Surgically induced astigmatism (SIA) was calculated by vector analysis and double angle plots (DAP) at 12 weeks postoperatively.Results:There were 22 males and 18 females with mean age of 58.12 ± 1.18 years. The mean SIA at 12 weeks was 0.85 ± 0.28 D in group A (17 eyes), 1.32 ± 0.65 D in group B (10 eyes), and 1.91 ± 0.69 D in group C (13 eyes). The overall median uncorrected visual acuity was 0.18 (IQR = 0 to 0.2). The mean astigmatism decreased from 1.95 ± 0.74 D to 1.04 + 0.57 D (P = 0.00) in superior incision and from 1.70 + 0.50 D to 0.92 ± 0.45 D (P = 0.00) in temporal incision group with central shift of centroid in all cases.Conclusion:The customization of on-axis external incision size can be used to manage pre-existing corneal astigmatism of less than 3.00 D using both temporal and superior incisions effectively. 相似文献
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C R Vishwaraj Srinivasan Kavitha Rengaraj Venkatesh Aakriti Garg Shukla Premanand Chandran Shweta Tripathi 《Indian journal of ophthalmology》2022,70(2):380
Neuroprotective therapies in glaucoma may play a role in preventing ischemia and oxidative damage that results in apoptosis of retinal ganglion cells and optic nerve damage. Although intraocular pressure (IOP) is the only known modifiable risk factor for glaucoma, disease progression commonly occurs despite IOP control, suggesting that factors other than IOP play a role in its pathogenesis and can potentially act as targets for neuroprotection. Factors including mediators of apoptosis, ischemic changes, poor ocular blood flow and neurotoxins have been hypothesized to play a role in glaucoma progression. Neuroprotective targets include glutamate-induced neurotoxicity, nitric oxidase synthetase, neurotropins, calcium channel receptors, free radicals, vascular insufficiency, the rho-kinase pathway, and more. Drugs related to these factors are being evaluated for their role in neuroprotection, although this area of investigation faces several challenges including limited evidence for these agents’ efficacy in clinical studies. Additionally, while IOP-lowering therapies are considered neuroprotective as they generally slow the progress of glaucoma progression, they are limited by the extent of their effect beyond IOP control. The aim of this article is to review the current treatment options available for neuroprotection and to explore the drugs in the pipeline. 相似文献
8.
Manushree Gautam Meenal Soni Vijay Bhaisare Preeti Rawat Shweta Walia Neetu Kori 《Indian journal of ophthalmology》2022,70(4):1365
Purpose:To study facial nerve palsy (FNP) in post-COVID-19-mucormycosis patients and its ocular complications, report different presentations of FNP in such patients, and propose its etiopathogenesis based on presentation and clinico-radiologic localization.Methods:A prospective cohort study was carried out in patients of post-COVID-19-mucormycosis who presented at our tertiary center, over a period of 3 months. Motor and sensory examination of the facial nerve was done to diagnose FNP and localize the lesion clinically. Slit-lamp examination was done for grading corneal involvement. MRI brain, orbit, and paranasal sinuses (PNS) with contrast were studied to find involvement along the facial nerve. It was assessed whether this site of lesion corresponded with clinical localization. Data were analyzed using the percentage of total cases and Fisher’s test.Results:A total of 300 patients with post-COVID-19 mucormycosis were examined, of which 30 (10%) patients were found to have FNP. All were lower motor neuron (LMN) type and were associated with corneal complications. The most common site clinically was distal to the chorda tympani (66.66%) and radiologically was infratemporal (IT) fossa (63.4%). The clinical localization significantly correlated with the radiological findings (P = 0.012). Twenty percent of patients showed incomplete involvement of facial musclesConclusion:FNP was found to be of LMN type. The most common site of insult was IT fossa. There was a good clinico-radiological correspondence of lesions. Isolated lesions were also found along the peripheral nerve course, presenting as incomplete facial palsy. Recognition of FNP in post-COVID-19 mucormycosis, in all its variable forms, is important to manage corneal complications. 相似文献
9.
The association between smoking prevalence and eating disorders: a systematic review and meta‐analysis 下载免费PDF全文
10.
Ila Datar Xiaoliang Qiu Hong Zhi Ma Miranda Yeung Shweta Aras Ivana de la Serna Fahd Al-Mulla Jean Paul Thiery Robert Trumbly Xuan Fan Hongjuan Cui Kam C. Yeung 《Oncotarget》2015,6(36):39050-39061
Accumulating evidence suggests that presence of macrophages in the tumor microenvironment add to the invasive and tumor-promoting hallmarks of cancer cells by secreting angiogenic and growth factors. RKIP is a known metastasis suppressor and interferes with several steps of metastasis. However, the mechanistic underpinnings of its function as a broad metastasis suppressor remain poorly understood. Here, we establish a novel pathway for RKIP regulation of metastasis inhibition through the negative regulation of RANTES/CCL5 thereby limiting tumor macrophage infiltration and inhibition of angiogenesis. Using a combination of loss- and gain-of-function approaches, we show that RKIP hinders breast cancer cell invasion by inhibiting expression of the CC chemokine CCL5 in vitro. We also show that the expression levels of RKIP and CCL5 are inversely correlated among clinical human breast cancer samples. Using a mouse allograft breast cancer transplantation model, we highlight that ectopic expression of RKIP significantly decreases tumor vasculature, macrophage infiltration and lung metastases. Mechanistically, we demonstrate that the inhibition of the CCL5 expression is the cause of the observed effects resulting from RKIP expression. Taken together, our results underscore the significance of RKIP as important negative regulator of tumor microenvironment. 相似文献