全文获取类型
收费全文 | 289篇 |
免费 | 9篇 |
国内免费 | 3篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 35篇 |
口腔科学 | 3篇 |
临床医学 | 14篇 |
内科学 | 76篇 |
皮肤病学 | 2篇 |
神经病学 | 18篇 |
特种医学 | 18篇 |
外科学 | 72篇 |
综合类 | 1篇 |
预防医学 | 5篇 |
眼科学 | 4篇 |
药学 | 24篇 |
肿瘤学 | 27篇 |
出版年
2022年 | 4篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 6篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 10篇 |
2012年 | 8篇 |
2011年 | 10篇 |
2010年 | 7篇 |
2009年 | 6篇 |
2008年 | 13篇 |
2007年 | 12篇 |
2006年 | 10篇 |
2005年 | 4篇 |
2004年 | 13篇 |
2003年 | 7篇 |
2002年 | 13篇 |
2001年 | 6篇 |
2000年 | 7篇 |
1999年 | 10篇 |
1998年 | 8篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 9篇 |
1991年 | 8篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 13篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1979年 | 5篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1975年 | 1篇 |
1974年 | 4篇 |
1972年 | 2篇 |
1971年 | 6篇 |
1970年 | 1篇 |
1969年 | 3篇 |
1967年 | 2篇 |
1966年 | 4篇 |
排序方式: 共有301条查询结果,搜索用时 15 毫秒
1.
The technique of extended lid-splitting surgery is described. This procedure was used to repair marginal defects of the lower
and upper lid, and provided postoperative results that were excellent both functionally and cosmetically, principally because
the technique allowed the anatomical structures to be maintained. 相似文献
2.
Inhibition of HIV-1 infectivity with curdlan sulfate in vitro 总被引:5,自引:0,他引:5
Y Kaneko O Yoshida R Nakagawa T Yoshida M Date S Ogihara S Shioya Y Matsuzawa N Nagashima Y Irie 《Biochemical pharmacology》1990,39(4):793-797
Polymethoxylated flavones and C-glycosyl derivatives isolated from medicinal plants besides other flavonoid compounds were studied for their influence on lipid peroxidation induced by FeSO4+ cysteine in rat liver microsomes. A number of hydroxyflavones (e.g. luteolin); C-glycosyl-flavones (e.g. orientin); methoxyflavones (e.g. gardenin D) and flavonols (e.g. datiscetin), as well as the flavanol leucocyanidol and the biflavone amentoflavone behaved as inhibitors of non-enzymic lipid peroxidation. Structure-activity relationships were established and it was observed that the structural features for active polyhydroxylated compounds were different from those of polymethoxylated flavones, antiperoxidative flavonoids possessing a high lipophilicity. 相似文献
3.
Yoshimitsu Kuroyanagi DR. ENG DR. SCI DR. MED ; Akihiko Shiraishi MD ; Yoshiteru Shirasaki MD ; Nobuaki Nakakita MD ; Yoshiaki Yasutomi MD ; Yasuo Takano MD ; Nobuyuki Shioya MD FACS 《Wound repair and regeneration》1994,2(2):122-129
A bilaminar wound dressing composed of an outer membrane and an inner three-dimensional matrix of a fabric or a sponge may be considered to constitute an ideal structure that promotes wound healing: the outer membrane prevents body fluid loss, controls water evaporation, and protects the wound surface from bacterial invasion, and the inner matrix encourages adherence by tissue growth into the matrix. Using this concept, we developed a biosynthetic wound dressing with a drug delivery capability. This medicated wound dressing is composed of a spongy sheet of a chitosane derivative and collagen mixture that is laminated to an antimicrobial-impregnated polyurethane membrane. In this study, a gentamycin sulfate-impregnated wound dressing was prepared and evaluated. The antimicrobial efficacy of this wound dressing was examined on an agar plate seeded with Pseudomonas aeruginosa. Also, the cytotoxicity of an antimicrobial released from this wound dressing was examined in an in vitro system with cultured skin substitutes. Both in vitro tests have shown that this wound dressing is capable of suppressing bacterial growth and minimizing cellular damage. In addition, in the treatment of wounds inflicted on rats and rabbits, this wound dressing was shown to be efficacious in covering full-thickness and split-thickness skin defects. Finally, the efficacy of this wound dressing was evaluated in a nonrandomized open-label study of 31 clinical cases. In 31 cases treated with this wound dressing, good or excellent wound healing was achieved. 相似文献
4.
The purpose of this study was to clarify the bronchodilating effect of pirenzepine (PZ) and to verify its mechanism. Ten asthmatic patients (6 men, 4 women: aged 20 to 65, 5 atopic 5 non-atopic) and ten non-asthmatic volunteers (8 men, 2 women: aged 25 to 60) were studied. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0) and peak expiratory flow rate (PEFR) were measured after intravenous administration of 20 mg PZ. PZ increased FVC, FEV1.0 and PEFR significantly by 15%, 29% and 37% respectively in asthmatic patients (p less than 0.01). We also studied the effects of PZ on the contractile responses of tracheal smooth muscle to intra-arterially administered acetylcholine (ACh) and the electrical stimulation of the vagus nerves (VNS) using isometric technique in situ in 5 mongrel dogs. PZ significantly inhibited the contractile responses elicited with ACh at doses larger than 1000 micrograms/kg (p less than 0.01). PZ also significantly inhibited the contractile responses elicited by VNS at doses larger than 100 micrograms/kg (p less than 0.01). These data demonstrate that intravenously administered PZ dilates the airway in asthmatic patients and also suggest that the bronchodilating effect of PZ related to inhibition of the M1 and M3 muscarinic receptors. 相似文献
5.
Takao Shioya Hiroko Matsuda Akinori Noma 《Pflügers Archiv : European journal of physiology》1993,422(5):427-435
The present patch-clamp study shows that external Mg2+, Ca2+ and Sr2+ decrease the unit amplitude of inward current through the inward-rectifier K+ channel in a concentration-dependent manner. Sr2+ produces a voltage-dependent flickering block as well, and the fractional electrical distance between the external orifice and the Sr2+ binding site () is 0.73. The decrease of unit amplitude is reversible and voltage independent while it does not increase the noise level on the open-channel current. Unit current decreased by Mg2+ or Ca2+ has a longer mean open time, which is inversely proportional to the unit amplitude. External Mg2+ does not decrease the amplitude of unit outward current. A surface potential shift, measured using voltage-dependent Cs+ block (=1.60), failed to explain the current decrease. Therefore, we conclude that (1) the external divalent cations cause an extremely fast channel block, which appears as a decreased amplitude of the unit current on the recording system; (2) the blocking site (fast site) is present near the external orifice of the channel, and it is separate from the blocking site (slow site) to which Cs+ and Sr2+ bind. 相似文献
6.
The effects of the activation of cyclic AMP-dependent Cl- current (ICl,cAMP) on cell volume were studied at various [K+]o under isosmotic conditions in guinea-pig ventricular myocytes. The area of the cell image obtained with videomicroscopy was used as an index of cell volume. I(Cl,cAMP) was activated by adrenaline (5.5 microM). Measurements of the membrane potential (Vm) were performed by the gramicidin-perforated patch-clamp method. At 5.4 mM [K+]o with low [Cl-]o, where Vm was negative to the predicted equilibrium potential of Cl- (ECl), adrenaline sizably decreased the cell area. At high [K+]o with normal [Cl-]o, where Vm was positive to ECl, adrenaline increased the cell area; at 145.4 mM [K+]o the cell area was increased to 110% of control on average (n = 22). The cells swollen in this manner shrank when [Cl-]o was reduced to a low level in the presence of adrenaline. The results indicate that the induction of Cl- influxes (outward I(Cl,cAMP)) or effluxes (inward I(Cl,cAMP)) can lead to a cell swelling or shrinkage, respectively. The addition of BaCl2 (1 mm), a blocker of K+ channels, attenuated the adrenaline-dependent cell swelling, supporting the view that Cl- fluxes must be accompanied by cofluxes of K+ ions to affect the cell volume. The adrenaline-dependent cell swelling was inhibited by antagonizing beta-adrenergic stimulation with acetylcholine or by blocking I(Cl,cAMP) channels with glibenclamide, confirming the involvement of I(Cl,cAMP) in the adrenaline response. The results show that the activation of I(Cl,cAMP) can shrink or inflate the cardiac cells under isosmotic conditions, depending on Vm and ECl. 相似文献
7.
Prof. Mitsuyoshi Nakashima PhD MD J. Yamamoto M. Shihata T. Uematsu H. Shinjo T. Akahori H. Shioya K. Sugiyama Y. Kawahara 《European journal of clinical pharmacology》1992,43(6):657-659
Summary The pharmacokinetics of temocapril hydrochloride, a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, has been studied in patients with mild (Group II) to severe (Group III) renal insufficiency in comparison with subjects with normal renal function (Group I).The pharmacokinetic parameters of the active diacid metabolite, including Cmax, AUC and half-life (t1/2), showed only slight changes between the three groups: AUC (0–) was significantly larger in Group III than Group I, and t1/2 tended to be prolonged in Group III, but the change was not significant.The urinary recovery of the diacid was significantly decreased in Group III. (Group I, 28.1 %, Group II, 21.6 %, Group III, 12.8 %). Compared with other ACE inhibitors, which are mainly excreted through the kidney, the plasma concentration of the active diacid metabolite was hardly influenced by renal function. It was speculated that lowering of the dose of temocapril might be recommended only in patients with severe renal insufficiency. 相似文献
8.
Subependymoma of the septum pellucidum: Characterization by PET 总被引:1,自引:0,他引:1
Mineura Katsuyoshi Shioya Hitoshi Kowada Masayoshi Ogawa Toshihide Hatazawa Jun Uemura Kazuo 《Journal of neuro-oncology》1997,32(2):143-147
We report the evaluation of a subependymoma of the septum pellucidum by positron emission tomography (PET) with analysis of 18F-fluorodeoxyglucose (FDG)kinetics. The tumor showed exceedingly low rates of glucose metabolism (rCMRG1) and kinetic constants (K1, K2, and K3). This hypometabolism indicates low cellular density and slow growth. 相似文献
9.
K Kamio Y Ono U Kamiya M Shimizu Y Ando I Kuwahira T Kondo S Shioya 《Nihon Kokyūki Gakkai zasshi》2002,40(6):473-477
The incidences of cardiovascular and cerebrovascular diseases are reportedly higher in patients with obstructive sleep apnea (OSA) than in OSA-free subjects, though the mechanism remains unknown. Recently, the contribution of activated platelets to a number of pathological conditions such as stroke or ischemic heart disease has been suggested. We hypothesized that the expression of activated platelet markers resulting from OSA might be higher than in healthy subjects. By flow cytometry using monoclonal antibodies, we measured two such markers, PAC-1 and CD 62 P, in OSA patients and healthy subjects. Twelve healthy men (age, 52.7 +/- 12.8 y/o; and body mass index (BMI), 22.2 +/- 16.1 kg/m2; mean +/- S.D.) and 20 male patients with OSA (age, 50 +/- 7.96 y/o; BMI, 28.1 +/- 3.3 kg/m2; apnea hypopnea index (AHI), 38.2 +/- 21.2 times/hr; and lowest SpO2, 75.6 +/- 11.3%) were enrolled in this study. PAC-1 expression was significantly higher in OSA patients (65.1 +/- 17.8%) than in healthy subjects (16.8 +/- 7.4%), as was CD 62 P expression (8.5 +/- 8.8% vs. 0.88 +/- 0.57%). The increase in PAC-1 expression was correlated with AHI and the arousal index. These findings suggest that activated platelet markers could be good indicators for untreated OSA. 相似文献
10.
Nobuki Shioya Nozomu Inoue Naonori Kawashima Yuki Tsukamoto Miyabi Nakayama Koji Hazama Yasuo Shichinohe Fumiyuki Suzuki Naotake Honma 《Internal medicine (Tokyo, Japan)》2021,60(1):91
As an intrathoracic goiter expands, it causes airway stenosis and phrenic nerve paralysis, and slight respiratory stimuli can trigger sudden life-threatening hypoventilation. A 78-year-old obese woman with a large intrathoracic goiter was found unconscious with agonal breathing in her room early in the morning. Cardiopulmonary resuscitation restored spontaneous circulation. She underwent surgical removal of the goiter; however, she required long-term mechanical ventilation because of atelectasis due to phrenic nerve paralysis. In patients with large intrathoracic goiters, difficulty breathing on exertion and diaphragm elevation on chest X-ray may be significant findings predicting future respiratory failure. 相似文献