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1.
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 23, No. 5, pp. 540–549, May, 1989. 相似文献
2.
T. A. Fedotcheva N. L. Shimanovskii A. I. Senderovich N. S. Chermnykh A. V. Semeikin V. M. Rzheznikov L. E. Golubovskaya G. S. Grinenko V. V. Banin P. V. Sergeev 《Pharmaceutical Chemistry Journal》2007,41(7):345-349
The hormonal compound with the highest cytostatic activity against MCF-7 tumor cells (human breast cancer, BC) and the lowest
activity against normal cells (rat skin fibroblasts) was sought among gestagens, androstenes, and antiestrogencytostatics.
It was found that antiestrogencytostatics and androstenes had the highest cytostatic activity against tumor cells whereas
gestagens and antiestrogencytostatics were least active against fibroblasts. Studies of the activity of the hormonal compounds
in combination with doxorubicin on the viability of MCF-7 and rat skin fibroblasts found that all investigated compounds with
the exception of dehydroepiandrosterone (DHEA) intensify the cytostatic activity of doxorubicin against tumor cells, the greatest
effect seen for antiestrogencytostatics. A chemoprotective effect of androstenes on normal cells was noted.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 7, pp. 3–7, July, 2007. 相似文献
3.
Restriction maps of the rDNA cistron of twelve species of mosquitoes in six genera of the subfamily Culicinae were constructed using eight 6 bp recognition restriction enzymes. Anopheles albimanus was used as an outgroup. The size of the rDNA cistron ranged from 8.5 kb in Aedes katherinensis to 12.9 kb in Ae. polynesiensis. A total of twenty-six sites were scored; eighteen were polymorphic among ingroup taxa. The proportion of polymorphic nucleotide sites (Pnuc) was 0.059 and the heterozygosity per nucleotide site (Hnuc) was 0.028. Wagner and Fitch Parsimony, Dollo Parsimony and Nei-Li distance/neighbour-joining methods were used to construct phylogenetic trees. The rDNA RFLP dataset did not provide a well-supported phylogeny among culicine taxa. The RFLP phylogenies are incongruent with the morphology character based and molecular phylogenies and derived relationships did not correspond with current taxonomic classifications. The lack of resolution was due to homoplasy arising from frequent independent loss or gain of restriction sites among unrelated taxa. 相似文献
4.
5.
Iu V Sergeev Iu P Reznikov E V Lobanova N S Pimenova 《Vestnik dermatologii i venerologii》1989,(4):4-7
Eighty-eight patients with atopic dermatitis have been examined for the complementary proteins C3 (C3c), C3act., C4, C1inact. by radial immunodiffusion; in 36 of these patients anaphylatoxins C3a des Arg, C5a des Arg, and C4a des Arg have been radioimmunoassayed. Increased levels of C4a des Arg have been revealed in 50% of the examinees. C3a des Arg levels did not differ significantly from the reference values, and C5a des Arg level has been within the normal range in all the patients. C4a des Arg has been related to the severity of the skin inflammation and did not depend on the serum IgE content. C3 (C3c), C3act., C1inact. have been elevated and C4 reduced. These findings evidence activation of the complementary system in atopic dermatitis and indicate the role of anaphylatoxin C4a des Arg in the maintenance of the inflammatory reactions. 相似文献
6.
7.
N. E. Kushlinskii N. N. Trapeznikov P. V. Sergeev Yu. N. Solov'ev M. D. Shikhammedov I. V. Babkina S. A. Chukaev Ch. M. Kasumov 《Bulletin of experimental biology and medicine》1997,123(6):599-600
The content of calmodulin in homogenates prepared from various morphological variants of primary osteogenic sarcoma varies
fromn 408 to 14,255 ng/mg total protein and is lowered by neoadjunctive chemotherapy. The 5-year incidence of metastases is
lower when the calmodulin content in the tumor is>6000 ng/mg protein. At calmodulin content<6000 ng/mg protein, the occurrence
of metastases is lower in patients receiving neoadjunctive therapy before surgery than in untreated patients.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 690–692, June, 1997 相似文献
8.
The authors suggest a unified system of designation of type--sizes of surgical suture materials of various nature and structure, which removes the existing discrepancy between the numbering of foreign and Soviet threads as well as of Soviet threads produced by different enterprises of the country. Introduction of the new system of metric sizes of the suture threads will allow surgeons to be properly orientated in the choice of the necessary suture material and make easier the work of services engaged in the development and realization of surgical suture materials. 相似文献
9.
10.
Alexandr G. Potapov Vladimir A. Zakharov Tatijana B. Mikenas Sergeyi A. Sergeev Alexandr M. Volodin 《Macromolecular chemistry and physics.》1997,198(9):2867-2873
ESR was used for studying the interaction between the stable nitroxyl radical TEMPO (2,2,6,6-tetramethylpyperidin-1-oxyl) and the titanium-magnesium catalysts TiCl4/MgCl2 and TiCl4/MgCl2 · nD (D is either diisobutyl phthalate or 2,2-diisobutyl-1,3-dimethoxypropane), as well as TiCl4/MgCl2 · nD treated with triethylaluminium. In all cases, only part of the surface titanium complexes (18–53 mol-%) exhibit Lewis acid properties and can interact with TEMPO. The portion of titanium complexes with acidic properties depends on the composition and preparation of the catalysts, and it decreases upon treatment with triethylaluminium. 相似文献