全文获取类型
收费全文 | 1747篇 |
免费 | 108篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 122篇 |
妇产科学 | 27篇 |
基础医学 | 226篇 |
口腔科学 | 31篇 |
临床医学 | 130篇 |
内科学 | 330篇 |
皮肤病学 | 22篇 |
神经病学 | 188篇 |
特种医学 | 44篇 |
外科学 | 296篇 |
综合类 | 30篇 |
一般理论 | 1篇 |
预防医学 | 81篇 |
眼科学 | 28篇 |
药学 | 170篇 |
中国医学 | 14篇 |
肿瘤学 | 109篇 |
出版年
2023年 | 16篇 |
2022年 | 17篇 |
2021年 | 51篇 |
2020年 | 20篇 |
2019年 | 40篇 |
2018年 | 56篇 |
2017年 | 32篇 |
2016年 | 49篇 |
2015年 | 67篇 |
2014年 | 77篇 |
2013年 | 102篇 |
2012年 | 146篇 |
2011年 | 159篇 |
2010年 | 85篇 |
2009年 | 64篇 |
2008年 | 119篇 |
2007年 | 110篇 |
2006年 | 122篇 |
2005年 | 98篇 |
2004年 | 75篇 |
2003年 | 58篇 |
2002年 | 74篇 |
2001年 | 29篇 |
2000年 | 17篇 |
1999年 | 35篇 |
1998年 | 12篇 |
1997年 | 14篇 |
1996年 | 15篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 7篇 |
1991年 | 14篇 |
1990年 | 5篇 |
1989年 | 9篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1919年 | 1篇 |
排序方式: 共有1862条查询结果,搜索用时 31 毫秒
1.
PURPOSE: Concern over stigma as a consequence of genetic testing has grown in response to the recent increase in genetic research and testing resulting from the Human Genome Project. However, whether a genetic or hereditary basis necessarily confers a stigma to a condition remains unexamined. METHODS: We performed a qualitative interview study with 86 individuals with one of four conditions: deafness or hearing loss, breast cancer, sickle cell disease, and cystic fibrosis. The first two groups were divided approximately between people who ascribed their conditions to a genetic or hereditary cause and those who did not. RESULTS: Respondents interpreted genetic or hereditary causes and nongenetic causes in a variety of ways. Subjects with breast cancer reported the most consistently negative interpretation of genetic cause. This response concerned future ill health, not an enduring sense of stigma. Deaf and hard of hearing subjects provided the most consistently positive comments about a genetic or hereditary basis to their condition, casting familial hearing loss as a vital component of group and individual identity. Respondents with sickle cell disease and cystic fibrosis offered similar and positive interpretations of the genetic cause of their condition insofar as it meant their conditions were not contagious. CONCLUSIONS: Although some subjects report feeling stigmatized as a result of their condition, this stigmatization is not uniformly associated with the condition's cause, genetic or otherwise. Instead, stigma emerges from a variety of sources in the context of the lived experience of a particular condition. 相似文献
2.
3.
Rajesh Venkataraman Karthik R. Vaidyanathan Madhu N. Sankar Kotturathu M. Cherian 《Journal of cardiac surgery》2009,24(4):443-445
Abstract Dissection of the pulmonary autograft is an extremely rare complication requiring emergent treatment as there is a chance of rupture and proximal aortic involvement. The autograft dissection can involve the aortic annulus, causing separation of leaflets from the annulus in addition to causing annular dilatation, thereby precluding resuspension of leaflets. The usual treatment in such cases is to perform the Bentall procedure, which involves placing a valved conduit (usually mechanical valve) and thereby necessitating anticoagulation. This report describes a case of successful valve-sparing aortic root replacement following the Ross procedure with dissection of autograft. 相似文献
4.
5.
6.
7.
P. J. Arumugam T. V. Chandrasekaran A. R. Morgan J. Beynon N. D. Carr 《Colorectal disease》2003,5(3):218-221
Introduction There have been many surgical techniques described for the treatment of pilonidal sinuses. Recurrent disease causes significant morbidity particularly with time from work. Aim To assess the rhomboid flap's role in promoting one‐stage primary healing in pilonidal disease and to evaluate the morbidity and recurrence. Methods Fifty‐three patients were prospectively recruited of which 27 had previous multiple abscess formation requiring surgical drainage from their pilonidal disease, although none had acute disease at the time of surgery. By using the transposition flap, we were able to obliterate the natal cleft and therefore the rolling action of the buttocks between the cleft in these patients and thereby remove one of the factors involved in pilonidal disease. Hospital stay, healing time, wound infection, wound breakdown and recurrence were noted. Results There were 47 males and 6 females with a median age of 28 years (range 16–64 years). Median follow‐up was 24 months (range 3–36 months). Post‐operative morbidity involved superficial wound infection in 7 (13%) which settled with out‐patient dressings. There were four recurrences (7%), two occurred between the flap and the anal canal, and the other two in the flap margin needing intervention. All the patients healed their wounds and the median healing time was 14 days. Conclusion As this condition affects a predominantly young population causing significant time off from work, we feel that the Rhomboid Flap is useful for difficult cases in that it allows early return to full activity and does not necessitate prolonged postoperative care. 相似文献
8.
E L Engelhardt M Sankar C Y Wu-Wang M R Thomas W R Walker J Neu 《Journal of pediatric gastroenterology and nutrition》1991,12(4):494-500
Using the neonatal piglet, the effects of dietary cholesterol deprivation on growth, intestinal enzyme activity, intestinal and hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and serum lipid were studied. Six litters of piglets were randomly assigned to one of two feeding regimens: restricted (800 ml of formula/24 h) versus unrestricted (1,200 ml of formula/24 h). Within litters, piglets were separated by sex, then randomly assigned to a formula containing low cholesterol (less than 2 mg/dl) or high cholesterol (145 mg/dl). Piglets were fed for 2 weeks. Male piglets in the restricted low cholesterol group gained significantly less weight per milliliter of formula than the restricted high cholesterol males. No effect was observed in the females. Microvillus membrane lactase activity was greater in males fed a high versus low cholesterol diet. Intestinal and hepatic HMG-CoA reductase activities and serum lipid profiles showed a trend toward compensation for dietary cholesterol deprivation but did not differ statistically between the cholesterol-fed versus -deprived groups. It is concluded that dietary cholesterol deprivation in the male neonatal pig causes alterations in growth, but no other statistically significant responses were detectable in this study. 相似文献
9.
L Hoffman-Goetz B MacNeil Y Arumugam J Randall Simpson 《International journal of sports medicine》1992,13(2):167-171
Acute exercise and exercise conditioning have been shown to affect the activity of natural killer (NK) cells as well as the growth of experimentally induced tumors in animals. Since psychosocial factors are also known to alter NK activity and tumor growth, isolation, a known psychosocial stressor of mice, was also investigated to see if housing condition could alter exercise-induced changes in NK cell activity and tumor growth. NK cell activity and concentration of asialo GM1 (ASGM1) positive splenocytes were measured in male C3H mice inoculated i.v. with CIRAS 3 tumor cells. Mice were housed individually or in groups of four and trained to run for eight weeks on a rodent treadmill; controls remained sedentary throughout the experimental period. At four weeks into the training protocol, mice were injected with the tumor cells and continued to run for four weeks after tumor exposure. There was a significant effect of physical activity (p less than 0.019) but not of housing on splenic NK cytotoxicity against tumor targets in vitro. When the data were analyzed by presence or absence of lung metastases, only those animals without visible lung tumors had significantly higher NK activity as a function of exercise relative to sedentary controls. There were no significant differences in the frequency of ASGM1+ splenocytes between trained and untrained animals, irrespective of presence or absence of lung tumor colonies. There was a significant effect of housing (p less than 0.02), but not of physical activity, in mice with successful tumor takes with greater numbers of group housed animals (29/59) with tumor relative to individually housed animals (13/60).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.
Endometriosis and infertility are commonly associated. Thisstudy investigated the role of accelerated lipid peroxidationof spermatozoa by the peritoneal fluid of patients with endometriosisas a cause for this association. It proposes that the increasediron concentration present in the fluid of these patients actsas a catalyst for the process. Peritoneal fluid from 25 patientswith endometriosis and 25 matched controls was obtained at laparoscopy.Spermatozoa were incubated in the fluid from both groups andthe subsequent acrosome reaction rates analysed. The relationshipbetween these results and iron concentration in the fluid wasexamined. A significant decrease in the acrosome reaction ratewas seen in the endometriotic group(P = 0.034). Overall, a decreasein the acrosome reaction rate was associated with an increasediron concentration in the fluid(18 of the 25 pairs). In milddisease, (six of 11 pairs), the relationship was not as markedas that in severe disease (12 of 14 pairs). These results suggestthat the peritoneal fluid in patients with endometriosis hasa detrimental action on the acrosome reaction of spermatozoain vitro. 相似文献