全文获取类型
收费全文 | 696篇 |
免费 | 47篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 18篇 |
妇产科学 | 24篇 |
基础医学 | 115篇 |
口腔科学 | 8篇 |
临床医学 | 65篇 |
内科学 | 220篇 |
皮肤病学 | 6篇 |
神经病学 | 35篇 |
特种医学 | 39篇 |
外科学 | 48篇 |
综合类 | 6篇 |
预防医学 | 50篇 |
眼科学 | 5篇 |
药学 | 40篇 |
肿瘤学 | 61篇 |
出版年
2023年 | 7篇 |
2022年 | 9篇 |
2021年 | 16篇 |
2020年 | 9篇 |
2019年 | 17篇 |
2018年 | 15篇 |
2017年 | 17篇 |
2016年 | 16篇 |
2015年 | 17篇 |
2014年 | 24篇 |
2013年 | 25篇 |
2012年 | 33篇 |
2011年 | 49篇 |
2010年 | 21篇 |
2009年 | 20篇 |
2008年 | 39篇 |
2007年 | 29篇 |
2006年 | 49篇 |
2005年 | 39篇 |
2004年 | 49篇 |
2003年 | 34篇 |
2002年 | 29篇 |
2001年 | 16篇 |
2000年 | 16篇 |
1999年 | 4篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 8篇 |
1995年 | 3篇 |
1992年 | 16篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 2篇 |
1987年 | 7篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1975年 | 7篇 |
1973年 | 5篇 |
1972年 | 3篇 |
1971年 | 6篇 |
1970年 | 2篇 |
1969年 | 2篇 |
排序方式: 共有743条查询结果,搜索用时 15 毫秒
1.
2.
3.
ALK Expression Defines a Distinct Group of T/Null Lymphomas (“ALK Lymphomas”) with a Wide Morphological Spectrum
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Brunangelo Falini Barbara Bigerna Marco Fizzotti Karen Pulford Stefano A. Pileri Georges Delsol Antonino Carbone Marco Paulli Umberto Magrini Fabio Menestrina Roberto Giardini Silvana Pilotti Alessandra Mezzelani Barbara Ugolini Monia Billi Alessandra Pucciarini Roberta Pacini Pier-Giuseppe Pelicci Leonardo Flenghi 《The American journal of pathology》1998,153(3):875-886
The t(2;5)(p23;q35) translocation associated with CD30-positive anaplastic large cell lymphoma results in the production of a NPM-ALK chimeric protein, consisting of the N-terminal portion of the NPM protein joined to the entire cytoplasmic domain of the neural receptor tyrosine kinase ALK. The ALK gene products were identified in paraffin sections by using a new anti-ALK (cytoplasmic portion) monoclonal antibody (ALKc) that tends to react more strongly than a previously described ALK1 antibody with the nuclei of ALK-expressing tumor cells after microwave heating in 1 mmol/L ethylenediaminetetraacetic acid buffer, pH 8.0. The ALKc monoclonal antibody reacted selectively with 60% of anaplastic large cell lymphoma cases (60 of 100), which occurred mainly in the first three decades of life and consistently displayed a T/null phenotype. This group of ALK-positive tumors showed a wide morphological spectrum including cases with features of anaplastic large cell lymphoma “common” type (75%), “lymphohistiocytic” (10%), “small cell” (8.3%), “giant cell” (3.3%), and “Hodgkin’s like” (3.3%). CD30-positive large anaplastic cells expressing the ALK protein both in the cytoplasm and nucleus represented the dominant tumor population in the common, Hodgkin’s-like and giant cell types, but they were present at a smaller percentage (often with a perivascular distribution) also in cases with lymphohistiocytic and small cell features. In this study, the ALKc antibody also allowed us to identify small neoplastic cells (usually CD30 negative) with nucleus-restricted ALK positivity that were, by definition, more evident in the small cell variant but were also found in cases with lymphohistiocytic, common, and “Hodgkin’s-like” features. These findings, which have not been previously emphasized, strongly suggest that the neoplastic lesion (the NPM-ALK gene) must be present both in the large anaplastic and small tumor cells, and that ALK-positive lymphomas lie on a spectrum, their position being defined by the ratio of small to large neoplastic cells. Notably, about 15% of all ALK-positive lymphomas (usually of the common or giant cell variant) showed a cytoplasm-restricted ALK positivity, which suggests that the ALK gene may have fused with a partner(s) other than NPM. From a diagnostic point of view, detection of the ALK protein was useful in distinguishing anaplastic large cell lymphoma cases of lymphohistiocytic and small cell variants from reactive conditions and other peripheral T-cell lymphoma subtypes, as well as for detecting a small number of tumor cells in lymphohemopoietic tissues. In conclusion, ALK positivity appears to define a clinicopathological entity with a T/null phenotype (“ALK lymphomas”), but one that shows a wider spectrum of morphological patterns than has been appreciated in the past. 相似文献
4.
Paulli M Viglio A Vivenza D Capello D Rossi D Riboni R Lucioni M Incardona P Boveri E Bellosta M Orlandi E Borroni G Lazzarino M Berti E Alessi E Magrini U Gaidano G 《Human pathology》2002,33(9):937-943
This study analyzes the pathologic and molecular features of 5 cases of primary cutaneous large B-cell lymphoma of the leg (PCLBCL-leg), recently included in the European Organization for Research and Treatment of Cancer (EORTC) classification of primary cutaneous lymphoma. PCLBCL-leg accounts for 5% to 10% of all primary cutaneous B-cell lymphoma (PCBCL), usually affects elderly patients and carries a worse prognosis than other forms of PCBCL. It has been proposed that the malignant cells of PCLBCL-leg originate from germinal center (GC)-related cells, but their effective normal counterpart is unclear, and the rationale behind the inclusion of this lymphoma as a separate entity is based on its prognosis rather than on its proved histogenesis. All of our cases of PCLBCL-leg morphologically resembled diffuse large B-cell lymphoma (DLBCL), but to better define their histogenesis, we also analyzed various phenotypic and genotypic markers, including mutations of the Ig and of BCL-6 genes, as well as expression of the bcl-6, MUM1, and CD138/syndecan-1 proteins. Immunohistochemically, all of our cases stained for the L-26/CD20cy and CD79a antigens and expressed the bcl-2, bcl-6, and MUM-1 proteins but were negative for both the CD10/CALLA and CD138 antigens. With respect to molecular analysis, the lymphoma population of all PCLBCL-leg carried hypermutation of Ig genes, and all but 1 case also harbored mutations of the BCL-6 gene. Our results indicate that PCLBCL-leg are similar both under the morphofunctional and molecular profiles to most DLBCL of other sites. Thus, caution seems justified before definitely considering PCLBCL of the leg as a distinct entity. 相似文献
5.
Malignant granular cell tumor of the lateral femoral cutaneous nerve: report of a case with cytogenetic analysis 总被引:5,自引:0,他引:5
Di Tommaso L Magrini E Consales A Poppi M Pasquinelli G Dorji T Benedetti G Baccarini P 《Human pathology》2002,33(12):1237-1240
Malignant granular cell tumors (MGCTs) are rare neoplasms of uncertain histogenesis. We report a case of MGCT involving a peripheral nerve with peritoneal and omental dissemination in which cytogenetic findings are available. Our results show that MGCTs share some cytogenetic abnormalities with malignant peripheral nerve sheath tumors (MPNSTs), supporting the hypothesis that they may represent histogenetically related lesions. 相似文献
6.
Seema Irfan Mohammad Zeeshan Salima Rattani Joveria Farooqi Sadia Shakoor Rumina Hasan Afia Zafar 《Emerging infectious diseases》2021,27(3):936
We evaluated Salmonella enterica serotype Typhi strains isolated from all body sites in Pakistan during 2013–2018. Despite an increase in overall number of localized, extensively drug-resistant Salmonella Typhi in organ infections during 2018, there was no increase in the proportion of such isolates in comparison with non–extensively drug-resistant isolates. 相似文献
7.
8.
9.
10.
Michael Bauer Uwe Kölsch Renate Krüger Nadine Unterwalder Karin Hameister Fabian Marc Kaiser Aglaia Vignoli Rainer Rossi Maria Pilar Botella Magdalena Budisteanu Monica Rosello Carmen Orellana Maria Isabel Tejada Sorina Mihaela Papuc Oliver Patat Sophie Julia Renaud Touraine Thusari Gomes Kirsten Wenner Xiu Xu Alexandra Afenjar Annick Toutain Nicole Philip Aleksandra Jezela-Stanek Ludwig Gortner Francisco Martinez Bernard Echenne Volker Wahn Christian Meisel Dagmar Wieczorek Salima El-Chehadeh Hilde Van Esch Horst von Bernuth 《Journal of clinical immunology》2015,35(2):168-181