全文获取类型
收费全文 | 243篇 |
免费 | 14篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 2篇 |
妇产科学 | 4篇 |
基础医学 | 28篇 |
口腔科学 | 2篇 |
临床医学 | 19篇 |
内科学 | 36篇 |
神经病学 | 23篇 |
特种医学 | 3篇 |
外科学 | 28篇 |
预防医学 | 14篇 |
药学 | 10篇 |
肿瘤学 | 88篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 4篇 |
2019年 | 1篇 |
2018年 | 3篇 |
2017年 | 4篇 |
2016年 | 3篇 |
2015年 | 5篇 |
2014年 | 7篇 |
2013年 | 8篇 |
2012年 | 17篇 |
2011年 | 15篇 |
2010年 | 12篇 |
2009年 | 21篇 |
2008年 | 11篇 |
2007年 | 18篇 |
2006年 | 11篇 |
2005年 | 16篇 |
2004年 | 14篇 |
2003年 | 14篇 |
2002年 | 14篇 |
2001年 | 12篇 |
2000年 | 8篇 |
1999年 | 7篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1980年 | 1篇 |
1969年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有258条查询结果,搜索用时 15 毫秒
1.
Alteration of cell cycle regulators correlates with survival in epithelial ovarian cancer patients 总被引:7,自引:0,他引:7
The p16-cyclinD1/CDK4-pRb pathway (RB pathway) and p14ARF-MDM2-p53 pathway (p53 pathway) work at the G1-S checkpoint, and the ATM-chk2-CDC25-cyclinB1/cdk1 pathway works at the G2-M checkpoint. The disruption of these pathways is thought to be related to the prognosis of human cancer. In this study, we analyzed the status of these pathways in 107 epithelial ovarian cancer (EOC) patients by immunohistochemistry and evaluated the relationship of these results with chemotherapy response and the prognosis. Altered RB, p53, and G2 pathways were detected in 50.5% (54/107), 51.4% (55/107), and 33.6% (36/107) of cases, respectively. The overall survival (OS) of 77.3% for patients with a normal RB pathway was significantly higher than the OS of 50.0% for patients with an altered RB pathway (by Kaplan-Meier analysis, P = 0.0021). The OS of 66.2% for patients with a normal G2 pathway was significantly higher than the OS of 58.3% for patients with an altered G2 pathway (P = 0.0416). However, the status of the p53 pathway was not related to OS. By univariate and multivariate analyses, advanced stage, high histological grade, altered RB pathway, and altered G2 pathway were significant predictors of poor OS. However, there was no significant relationship between pathway status and chemotherapy response. The status of the RB pathway and of the G2 pathway were independent prognostic factors of EOC. 相似文献
2.
Sakuragi T Fujiwara K Akashi-Tanaka S Tsuda H Fukutomi T 《Breast cancer (Tokyo, Japan)》1997,4(1):53-56
Dermatofibrosarcoma protuberans (DFSP) is a slow-growing but locally aggressive, fibrous tumor that has a high rate of local
recurrence after surgical resection. This tumor occurs most commonly in the trunk and proximal extremities. In this report
we present a case of dermatofibrosarcoma protuberans in the skin over the breast which was re-excised after pathological diagnosis,
considering cosmetic aspects. Only three other cases of dermatofibrosarcoma protuberans of the anterior chest wall have been
encountered in our hospital, and all of these cases were male. The presence of this tumor in the skin over the breast appears
to be rare in females. Careful complete resection is recommended for this type of tumor. 相似文献
3.
Tsubosa Y; Fukutomi T; Tsuda H; Kanai Y; Akashi-Tanaka S; Nanasawa T; Linuma G; Ushio K 《Japanese journal of clinical oncology》1998,28(1):42-46
We report a case of invasive breast cancer in a 62-year-old female patient
with Cowden's disease. A left modified radical mastectomy was performed and
histopathology of the tumor showed invasive ductal carcinoma, histological
grade 3, without lymph node metastasis. The patient had a past history of
endometrial cancer at 55 but did not have a family history of malignant
disease. Goiter was palpable but aspiration cytology revealed no
malignancy. There were several papillomas on the oral mucosa and multiple
papillomatous lesions on the right femur. Barium X-ray and endoscopic
examination revealed multiple, small, hyperplastic polypoid lesions on the
esophagus, stomach and rectum. Histopathology of the biopsy specimens from
the esophagus and stomach showed acanthotic squamous epithelium and
foveolar hyperplastic polyps. The patient was followed up closely to
monitor the thyroid lesions and polyposis of the digestive tract. A total
of 12 breast cancer patients who also had Cowden's disease have been
reported in Japan and these cases are reviewed in this report.
相似文献
4.
Fujii K; Fukutomi T; Tsuda H; Akashi-Tanaka S; Nanasawa T; Kanai Y; Muramatsu Y 《Japanese journal of clinical oncology》1998,28(1):47-49
A 44-year-old woman presented with a right huge axillary mass. Both
mammography and ultrasonography revealed a primary cancer of 2.8 cm maximum
diameter in the right breast and metastases in the axillary lymph nodes,
both being confirmed by aspiration cytology as ductal carcinoma. Right
standard radical mastectomy with level III axillary lymph node dissection
was carried out. Pathologically, the tumor was diagnosed as ductal
carcinoma in situ with microinvasion (DCISM), histologic grade 3. The area
of stromal invasion measured 1 mm at its widest point. Sixteen of the 17
resected axillary lymph nodes contained metastases, including six level III
lymph nodes. Immunohistochemical studies of the tumor revealed
overexpression of p53 protein, but not that of c-erbB-2 protein. The
frequency of lymph node metastases from DCISM is reported to be very low.
Therefore, the present case with extensive involvement of level III lymph
nodes was unusual.
相似文献
5.
M Saimura T Fukutomi H Tsuda H Sato K Miyamoto S Akashi-Tanaka T Nanasawa 《Journal of surgical oncology》1999,71(2):101-105
BACKGROUND AND OBJECTIVES: The objectives of this study were to confirm the favorable outcome of Japanese invasive breast cancer patients without lymph node metastasis, after treatment with surgery alone, and to evaluate clinicopathological prognostic factors in this population. METHODS: The subjects were 763 consecutive node-negative invasive breast cancer patients who underwent surgery without adjuvant therapies between 1988 and 1993 at our hospital. Disease-free survival (DFS) and overall survival (OS) rates were analyzed by clinicopathological factors. RESULTS: The median age of the patients at surgery was 52 years and the median follow-up period of patients was 74 months. At 5 years, the respective DFS and OS rates of all patients were 90.8% and 93.9%. Patients with a pathological tumor size of invasive component of more than 2 cm (319 patients) had a significantly lower DFS than those with tumors measuring 2 cm or less (361 patients) (P = 0.045). Patients with positive hormone receptor status (280 patients) (estrogen and/or progesterone receptor positive) tended to have a better OS than those negative for both hormone receptors (92 patients) (P = 0.078). Meanwhile, patients with tumors of histological grade 3 (328 patients) had a much poorer prognosis than those with tumors of histological grade 1 or 2 (413 patients) (P = 0.008 for OS and P = 0.042 for DFS). The respective 5-year DFS and OS rates of patients with histological grade 3 tumors larger than 2 cm in pathological tumor size of invasive component (195 patients) were 85.5% and 87.6%, indicating that these node-negative patients form a high risk group. CONCLUSIONS: Japanese invasive breast cancer patients without lymph node metastasis tended to show a survival advantage compared with their Caucasian counterparts. Histological grade was the most useful prognostic factor in this population. 相似文献
6.
Ueno Shu-ichi; Kondoh Keiji; Komure Yasunori; Komure Osamu; Kuno Sadako; Kawai Jun; Hazama Fumitada; Sano Akira 《Human molecular genetics》1995,4(4):663-666
An unstable expansion of CAG repeat in the coding region ofthe DRPLA gene on chromosome 12p is the mutation specific forhereditary dentatorubralpallidoluysian atrophy (DRPLA). We studiedthe CAG expansion in brain and other tissues from six unre latedDRPLA patients. The CAG repeat lengths showed distinct difterencesbetween tissues. The sizes of the CAG expansion in various regionsof the brain except the cerebellum were generally larger byseveral repeats than in other peripheral tissues. Brain samplesshowed greater variation of the expansion compared with othertissues, but neither the size of the CAG expansion nor the degreeof CAG repeat variation parallels the detailed findings of neuropathologicalinvolvement. We conclude that somatic instabilities of the CAGrepeat cause tissue variability of the CAG repeat size in DRPLAbut other region or cell type-specific factors would be involvedto explain the selectivity of cell damage in DRPLA. 相似文献
7.
Sadako Nakamura Masayuki Takami Kenichi Tanabe 《International journal of food sciences and nutrition》2014,65(6):754-760
The digestibility of Megalosaccharide® (newly developed carbohydrate comprising α-1,4-glucosaccharide) was investigated in vitro and in vivo. Isomaltosyl-megalosaccharide® (IMS) and nigerosyl-megalosaccharide® (NMS) contain 20% and 50% of the megalosaccharide fraction (degree of polymerization (DP) 10–35), respectively. IMS was hydrolyzed readily by α-amylase to oligosaccharides (DP?≤?7), and a small amount of glucose was produced from oligosaccharides by small intestinal enzymes (SIEs). NMS was partially hydrolyzed by α-amylase to oligosaccharides, and a small amount of glucose produced by SIEs. When IMS and NMS were treated by SIEs after treatment with human saliva α-amylase for a few minutes, IMS and NMS were hydrolyzed readily to glucose. Plasma levels of glucose and insulin upon ingestion of 50?g of IMS or NMS were elevated the same as those for 50?g of glucose, and breath hydrogen was not excreted. These results suggest that IMS and NMS are digestible carbohydrates. 相似文献
8.
Yuki Igarashi Sho Tashiro Yuki Enoki Kazuaki Taguchi Kazuaki Matsumoto Hiroki Ohge Hiromichi Suzuki Atsushi Nakamura Nobuaki Mori Yoshitomo Morinaga Yuka Yamagishi Sadako Yoshizawa Katsunori Yanagihara Hiroshige Mikamo Hiroyuki Kunishima 《Journal of infection and chemotherapy》2018,24(11):907-914
At present, vancomycin (VCM) and metronidazole (MNZ) are used for the first-line standard treatment of Clostridioides difficile infection (CDI). However, their differential use has not been sufficiently investigated. In this study, a meta-analysis on differences in the efficacy for CDI between VCM and MNZ was performed. Reports of randomized controlled studies using VCM or MNZ to treat CDI were surveyed. Meta-analysis was performed using the Mantel-Haenszel method and random-effects model, and the risk ratio and 95% confidence interval were calculated. Excluding overlapping reports, 1043 reports were extracted and 5 randomized controlled studies were extracted. There was no difference in therapeutic effects for CDI between VCM and MNZ (RR = 1.08, 95% CI (0.99–1.17), p = 0.09, I2 = 37%). On subgroup analysis by the severity, there was no difference in the clinical effects for CDI between VCM and MNZ in non-severe cases (risk ratio: 1.09, 95% confidence interval: 1.00–1.19, p = 0.06), but the clinical effects of VCM were significantly higher than those of MNZ in severe cases (risk ratio: 1.19, 95% confidence interval: 1.02–1.39, p = 0.03). No significant difference was noted in the recurrence rate, incidence of adverse event, time to exhibit therapeutic effects, or judgment of the bacteriological effects. As the therapeutic effects of VCM were superior in severe CDI cases, VCM should be considered first in severe cases. 相似文献
9.
10.