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排序方式: 共有198条查询结果,搜索用时 15 毫秒
1.
Xiaoyan Tang Sadaaki Hori R. Yoshiyuki Osamura Yutaka Tsutsumi 《Pathology international》1995,45(1):34-44
Extensive immunohistochemical analyses of the hyperplastic human palatine tonsil disclosed variegated B cell phenotypes on the lymphoid cells among the crypt epithelium. The reticular epithelial network was evident by cytokeratin immunostaining. The reticular epithelium near the crypt Iumen was positive for Iysozyme. Secretory component was negative, while HLA-DR was frequently expressed. Intramucosal small Iymphocytes, densely distributed in the Iuminal side, consisted mainly of B cells expressing CD19, CD20, CD21, CD22, CD45R, CD74, DBB42, HLA-DR, HLA-DQ, bcl-2 protein and surface lgM. Some B cells revealed mantle zone phenotypes (surface IgD+, CD5+, CD24+, DBA44+, CD10- -, DNA7- -). Cells of germinocyte phenotype (CD10+, DNA7+) were sparsely seen. A good number of intramucosal lymphoid cells were further labeled for CD11b, a phenotype of so-called B-1 cells. Plasma cells were clustered within the basal half. IgG was their major immunoglobulin class, followed by IgA, IgM and lgD classes. A smaller number of T cells (CD2+, CD3+, CD5+, CD45RO+, TCR αβ+) were identified among the epithelium. CD4+ cells predominated over CD8+ cells. TCR γΔ + cells were rare. Macrophages (CD68+), dendritic histio-cytes (S-100 protein+, CD1+), and natural killer cells (CD16+ or CD57+) were also dispersed. Another unique feature of this lymphoepithelial complex was the existence of HLA-DR intramucosal microvasculature, where lymphocyte recirculation was suggested. Proliferating cell nuclear antigen was detected commonly in the epithelial cells but rarely in the lymphoid cells. Possible lymphoepithelial interactions and morphologic similarities to the thymic medulla are discussed. 相似文献
2.
Baba H Maehara Y Takeuchi H Inutsuka S Yamamoto M Endo K Sugimachi K 《International journal of oncology》1994,4(2):329-333
In an attempts to increase the antitumor effect and to reduce normal tissue toxicity, the combined cytotoxic effect of cis-Diamminedichloroplatinum (II) (CDDP) and cis-diammine(1,1-cyclobutane dicarboxylate) platinum (II) (CBDCA) was investigated using HeLa and colon 26 cell lines and the combination index (CI). Cytotoxicity of the combination of CDDP and CBDCA on 27 surgically resected specimens of human gastric and colorectal adenocarcinomas was also evaluated using the in vitro succinate dehydrogenase inhibition (SDI) test. The CI values varied with the dose ratio examined (1:1-1:6) of CDDP and CBDCA, with findings that CI<1, synergy, was obtained at fraction affected (Fa)>0.75 for HeLa cells and at Fa<0.9 for colon 26 cells in cases of a dose ratio of 1:1 to 1:2. Of all 27 clinical human adenocarcinomas, the succinate dehydrogenase (SD) activity was significantly lower in cancer cells concomitantly exposed to both CDDP and CBDCA than in those exposed to either drug alone. These positive effects of a combination of two platinum analogues on human malignant tissues have heretofore not been reported, which would warrant the clinical application of this combination for human malignant tumors. 相似文献
3.
Total Esophagectomy versus Proximal Esophagectomy for Esophageal Cancer at the Cervicothoracic Junction 总被引:1,自引:0,他引:1
Fujita H Kakegawa T Yamana H Sueyoshi S Hikita S Mine T Tanaka Y Ishikawa H Shirouzu K Mori K Inoue Y Tanabe HY Kiyokawa K Tai Y Inutsuka H 《World journal of surgery》1999,23(5):486-491
To investigate the adequate extent of esophagectomy and lymphadenectomy for an esophageal cancer localized at the cervicothoracic
junction, the mortality and morbidity rates, survival rates, and patterns of recurrence were retrospectively analyzed in two
groups—14 patients who underwent total esophagectomy with or without laryngectomy and 15 patients who underwent proximal esophagectomy
with or without laryngectomy—at Kurume University Hospital from 1981 to 1996. Proximal esophagectomy with or without laryngectomy
resulted in a lower hospital mortality rate and better overall survival for patients who underwent curative esophagectomy
compared with total esophagectomy with or without laryngectomy. Multivariate analysis indicated that the extent of esophagectomy
(total esophagectomy versus proximal esophagectomy) was not a prognostic factor. The incidence of recurrence was not different
between the two groups. Lymph node metastasis or recurrence from such esophageal cancers was localized to the neck and upper
mediastinum. For an esophageal cancer localized at the cervicothoracic junction, therefore, proximal esophagectomy with or
without laryngectomy and with cervical and upper mediastinal lymphadenectomy could be better indicated for preselected patients. 相似文献
4.
Masayuki Honda Fumio Takesue Mitsuhiro Yasuda Sadaaki Inutsuka Tadahiro Nozoe Daisuke Korenaga 《Digestive endoscopy》2002,14(4):171-174
We report a case of cholecystolithiasis associated with situs inversus totalis (SIT) that had been successfully treated with a laparoscopic cholecystectomy. Although cholecystolithiasis associated with SIT is rare, trained surgeons who perform unusual surgical procedures, even if they have not experienced such a case, would perform laparoscopic cholecystectomy for cholecystolithiasis associated with SIT easily and safely. 相似文献
5.
Hideki Ishikura Takeya Ono Sadaaki Oki Yasukazu Saito Namiko Umei Wakako Tsumiyama Atsushi Tasaka Kazuki Aihara Yuta Sato Tomohiro Matsumoto Akira Otsuka 《Journal of Physical Therapy Science》2015,27(9):2821-2823
[Purpose] The purpose of this study was to investigate how a stretching torque affects
muscular contractures. [Subjects] The subjects of this study were 48 male Wistar rats.
[Methods] Subjects were divided into 4 groups as follows: Group 1 was the control; Group 2
had muscles in continuous fixation; Group 3 had muscles stretched in the direction of
dorsiflexion by a spring balancer set at a torque of 0.3N for a period of 30 minutes after
continuous fixation; and Group 4 had muscles stretched in the direction of dorsiflexion by
a spring balancer set at a torque of 3.0N for a period of 30 minutes after continuous
fixation. Joint fixation periods were for 2 and 4-weeks. Ankle joint range of motion and
soleus flexibility were analyzed. [Results] For the 2-week joint fixation, soleus
flexibility in Group 4 showed an increase compared with that of Group 3. For both fixation
periods, range of motion in Group 4 showed an increase compared with that of Group 3.
[Conclusion] For both fixation periods, stretching improved joint range of motion. In the
2-week joint fixation, soleus flexibility improved. However, soleus flexibility did not
improve in the 4-week joint fixation.Key words: Muscular contracture, Stretching, Muscular flexibility 相似文献
6.
Tamura S Fukamiya N Okano M Tokuda H Aoi W Mukainaka T Nishino H Tagahara K Koike K 《Cancer letters》2002,185(1):47-51
A series of shinjulactone C (1) derivatives (2-8) were synthesized and evaluated for their anti-tumor promoting effects against Epstein-Barr virus early antigen activation introduced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The succinate and 3',3'-dimethylsuccinate derivatives of 1 exhibited higher inhibitory effects than 1. From the point of view of structure-activity relationships, the succinate derivatives (2, 4) demonstrated better potency than the glutarate derivatives (3, 5-8). As substituted moieties of 3'-position became bulky, the inhibitory effects of the glutarate derivatives (7, 8) significantly decreased. 相似文献
7.
8.
Y Sannohe M Hirano T Shirakusa R Hiratsuka K Doki S Inutsuka 《The Japanese journal of surgery》1979,9(4):366-371
One-shot intratumor injection of 60 mg oil-bleomycin prior to subtotal esophagectomy induced fatal, acute interstitial pneumonitis in a 53 year-old esophageal circinoma patient. The progression of bleomycin-induced pneumonitis was rapid and the patient succumbed to respiratory insufficiency 41 days after surgery (58 days after bleomycin administration). Autopsy revealed bilaterally increased lung weight and the organ was of rubbery consistency and anthracotic. Histology showed advanced interstitial fibrosis, numerous lymphocytes in alveolar septi and fibrinous exudate, macrophages and desquamative cells within the alveolar spaces. In the present case, pneumonitis was due not to patient age or dosage level of bleomycin, but rather to the administration method. 相似文献
9.
10.
Optimum Treatment Strategy for Superficial Esophageal Cancer: Endoscopic Mucosal Resection versus Radical Esophagectomy 总被引:3,自引:0,他引:3
Fujita H Sueyoshi S Yamana H Shinozaki K Toh U Tanaka Y Mine T Kubota M Shirouzu K Toyonaga A Harada H Ban S Watanabe M Toda Y Tabuchi E Hayabuchi N Inutsuka H 《World journal of surgery》2001,25(4):424-431
This study was designed to determine the optimum treatment for a superficial esophageal cancer involving the mucosal or submucosal
layer of the esophagus. The subjects were 150 patients with a superficial esophageal cancer who underwent endoscopic mucosal
resection (EMR) or esophagectomy in Kurume University Hospital from 1981 to 1997. The mortality and morbidity rates, survival
rate, and recurrence rate were retrospectively compared for (1) 35 patients who underwent EMR and 37 patients who underwent
esophagectomy for a mucosal esophageal cancer and (2) 45 patients who underwent extended radical esophagectomy and 33 patients
who underwent less radical esophagectomy for a submucosal esophageal cancer. Among the 72 patients with a mucosal cancer,
lymph node metastasis/recurrence was observed in only one (1%); whereas of 78 patients with a submucosal cancer it was observed
in 30 (38%). Among patients with a mucosal cancer the mortality and morbidity rates after EMR were lower than for those after
esophagectomy. The survival rate after EMR was the same as that after esophagectomy. No recurrence was observed after either
treatment modality. Among the patients with a submucosal cancer, the survival rate was higher and the recurrence rate lower
after extended radical esophagectomy; than after less radical esophagectomy; the mortality and morbidity rates after extended
radical esophagectomy were the same as those after less radical esophagectomy. Multivariate analysis demonstrated that the
treatment modality (EMR versus esophagectomy) did not influence the survival of patients with a mucosal esophageal cancer,
whereas it strongly influenced the survival of patients with a submucosal esophageal cancer. We concluded that EMR was the
mainstay of treatment for a mucosal esophageal cancer, and extended radical esophagectomy was the mainstay of treatment for
a submucosal esophageal cancer. 相似文献