全文获取类型
收费全文 | 1352篇 |
免费 | 17篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 6篇 |
妇产科学 | 2篇 |
基础医学 | 139篇 |
口腔科学 | 12篇 |
临床医学 | 35篇 |
内科学 | 403篇 |
皮肤病学 | 72篇 |
神经病学 | 262篇 |
特种医学 | 8篇 |
外科学 | 127篇 |
综合类 | 4篇 |
预防医学 | 21篇 |
眼科学 | 9篇 |
药学 | 93篇 |
中国医学 | 4篇 |
肿瘤学 | 180篇 |
出版年
2021年 | 6篇 |
2019年 | 5篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 10篇 |
2014年 | 15篇 |
2013年 | 20篇 |
2012年 | 41篇 |
2011年 | 44篇 |
2010年 | 33篇 |
2009年 | 35篇 |
2008年 | 67篇 |
2007年 | 87篇 |
2006年 | 83篇 |
2005年 | 75篇 |
2004年 | 81篇 |
2003年 | 93篇 |
2002年 | 76篇 |
2001年 | 16篇 |
2000年 | 19篇 |
1999年 | 23篇 |
1998年 | 24篇 |
1997年 | 23篇 |
1996年 | 37篇 |
1995年 | 35篇 |
1994年 | 25篇 |
1993年 | 30篇 |
1992年 | 30篇 |
1991年 | 25篇 |
1990年 | 24篇 |
1989年 | 27篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 18篇 |
1985年 | 13篇 |
1984年 | 13篇 |
1983年 | 8篇 |
1982年 | 14篇 |
1981年 | 14篇 |
1980年 | 9篇 |
1979年 | 9篇 |
1978年 | 15篇 |
1977年 | 10篇 |
1976年 | 11篇 |
1975年 | 11篇 |
1974年 | 14篇 |
1973年 | 8篇 |
1972年 | 9篇 |
1969年 | 5篇 |
1968年 | 8篇 |
排序方式: 共有1381条查询结果,搜索用时 15 毫秒
1.
Yohei Mizuta Fuminao Takeshima Saburo Shikuwa Satoshi Ikeda Shigeru Kohno 《Digestive endoscopy》2006,18(2):88-97
Obstructive sleep apnea syndrome (OSAS) is a common condition characterized by repetitive sleep‐induced collapse of the upper airways. It is associated with increased risk for hypertension, ischemic heart disease, cerebral stroke, and traffic accidents. In contrast, gastroesophageal reflux disease (GERD) is a very common disorder defined as various symptoms or esophageal mucosal damage generated by the abnormal reflux of gastric contents into the esophagus. Patients with OSAS have been reported to have a high prevalence of gastroesophageal reflux (GER) symptoms. The increase of transdiaphragmatic pressure in parallel with the large negative intrathoracic pressure produced during apnea events may directly lead to GER. In addition, some studies have demonstrated improvement in GERD with the application of continuous positive airway pressure, most consistently effective treatment for OSAS. However, GER dose not occur with every apnea. Moreover, the common conditions observed in patients with OSAS, including obesity or alcohol ingestion, are also predisposing factors for GER. A more recent investigation in over 1000 subjects failed to show a causal link between both diseases. Thus, the potential relationship between OSAS and GERD remains controversial. Inconsistencies in definitions of both diseases or sampling biases may contribute to the confusing results. 相似文献
2.
A 62-year-old woman with rheumatoid arthritis, Basedow's disease and arrhythmia has been treated with antirheumatic, antiarrhythmic drugs and so on. She developed pruritic diffuse erythema with papules on the trunk and extremities 2 days after taking hydroxyzine pamoate for asteatotic eczema. Laboratory data showed increased levels of eosinophils. Histopathological examination revealed a infiltrate of inflammatory cells in the upper dermis. Patch tests with hydroxyzine pamoate and hydroxyzine hydrochloride were positive. From these findings, we diagnosed this case as drug eruption due to hydroxyzine. Her eruption subsided after she discontinued hydroxyzine pamoate and other drugs which were started within 5 days before the onset of the eruption and was treated with systemic steroid, systemic antiallergic drug and topical steroid. 相似文献
3.
4.
5.
Yasunori Cho Satoru Suzuki Masakazu Yokoi Muneaki Shimada Saburo Kuwabara Akira Murayama 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(10):476-479
Lymphoblastic lymphoma, an aggressive mediastinal mass, is recognized as serious threat to the patient in developing cardiac
tamponade or airway obstruction. Surgical procedure is often required to relieve clinical emergency and to establish prompt
pathological diagnosis. However, in such a patient, acute respiratory occlusion in the spine position can be a life-threatening
complication during general anesthesia. We describe a 17-year-old man whose cardiac tamponade was treated by pericardial-pleural
window through a left anterior thoracotomy in the lateral position. The patient recovered from hemodynamic compromise without
showing respiratory occlusion during general anesthesia and remained in the lateral position until extubation. Pathological
diagnosis was precursor T-lymphoblastic lymphoma. There were no complications attributable to the operative procedure. Further
chemotherapy reduced the mediastinal mass in size after two weeks when the patient developed sepsis and died. Lateral position
prevents respiratory occlusion during surgical procedure under general anesthesia in the patient of huge anterior mediastinal
tumor with airway obstruction. 相似文献
6.
Tadahito Kanda Takashi Onda Soichi Zanma Toshiharu Yasugi Akemi Furuno Sumie Watanabe Takashi Kawana Motoyasu Sugase Kuniaki Ueda Takahiko Sonoda Saburo Suzuki Takenobu Yamashiro Hiroyuki Yoshikawa Kunito Yoshiike 《Virology》1992,190(2)
The E4 open reading frame (ORF) of human papillomaviruses (HPVs) is transcribed in abundant mRNAs encoding an
fusion gene during the productive infection, and the HPV 16 E7 ORF encodes an oncoprotein detectable in the cell lines derived from cervical carcinoma. We examined 421 human sera, which included 108 samples from the patients with cervical carcinoma, for the presence of IgG antibodies against the HPV 16 E4 and E7 proteins by enzyme-linked immunosorbent assay. Bacterially expressed fusion protein lac-
and nonfusion protein E7 were purified and used as antigens. All of the 22 serum samples positive for anti-E7 antibody and the 11 out of 15 samples positive for anti-
antibody were from the patients with cervical carcinoma, but only one sample was found to contain both anti-
and anti-E7 antibodies. These findings show specific and independent association of these antibodies with cervical carcinoma. 相似文献
7.
Fibrate for treatment of primary biliary cirrhosis 总被引:1,自引:0,他引:1
Shinji Iwasaki Naoaki Akisawa Toshiji Saibara Saburo Onishi 《Hepatology research》2007,37(S3):S515-S517
Recent studies of the effectiveness of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cirrhosis (PBC) reported that UDCA therapy did not necessarily stop the progression of liver fibrosis in all patients, even those with early stage PBC. Thus, there is a need for more effective treatments that could prevent asymptomatic PBC from progressing to the icteric stage. Bezafibrate is effective in approximately two-thirds of non-icteric patients who have not shown a complete response to UDCA. Serum bilirubin, aspartate aminotransferase and γ-guanosine 5'-triphosphate levelswere significantly lower in patients who responded to additional bezafibrate on univariate analysis. The putative mechanism by which bezafibrate acts in cholestasis is by increasing phospholipid output into bile, which forms micelles with the hydrophobic bile acid that reduces its toxicity. 相似文献
8.
Masahiro Fujita Kazuhiko Ito Hiroshi Kawamoto Saburo Kashii Mihoko Norioka Sumie Monden Minoru Okuma 《European journal of haematology》1993,50(4):200-205
Abstract: A cell line, BAD05, derived from B lymphocytes of an adenosine deaminase (ADA; EC 3,5,4,4)-deficient patient could not proliferate in a serum-free medium containing 100 μmol/l deoxyadenosine. When BAD05 was cultured with ADA-positive fibroblasts, the proliferation of BAD05 was improved. BAD05 cell density increased when the initially mixed ratio of fibroblasts/BAD05 was 1/10 or higher, but decreased when the ratio was 1/20 or lower. Deoxyadenosine concentrations in the medium and ATP and deoxyATP (dATP) levels in the BAD05 were measured after 4 hours of coculture at initial BAD05 cell densities of 1 × 105and 1 × 106cells/ml. Deoxyadenosine concentrations in the medium decreased as the density of fibroblasts increased. The dATP level decreased as the mixed ratio rose. The ratio of fibroblasts/BAD05 rather than the cell density of fibroblasts had a larger effect on the dATP levels in BAD05. Under our experimental conditions, ADA-negative cells proliferated well when the ratio of ADA-positive cells/ADA-negative cells was over 1/10. 相似文献
9.
Naoji Amano Saburo Yagishita Susumu Yokoi Yoji Itoh Jun Kinoshita Toshio Mizutani Takeshi Matsuishi 《Acta neuropathologica》1992,84(1):15-23
Summary This report presents a variant of Gerstmann-Sträussler syndrome (GSS). A 53-year-old female had developed slowly progressive dementia and atactic gait since the age of 45. No myoclonic jerks and periodic synchronous discharges were observed throughout the illness. The neuropathological study revealed that many amyloid plaques and widespread Alzheimer's neurofibrillary tangles (NFTs) appeared in the cerebral cortex. Characteristically, the plaques reacted with anti-prion protein and none of them reacted with anti- protein, and they were made of many components, including amyloid cores, macrophages laden with lipid granules and/or degenerated neurites. Neuropil threads were seen mainly in amyloid plaques. Moreover, plaques appeared which were confluent and laminar in arrangement in the fifth and sixth cortical layers and had a close relationship to the neuronal loss. There was no spongiform change in the cerebral cortex or cerebellum. The cerebellum was almost intact except for a few amyloid plaques. Ultrastructurally, some of the plaques simulated kuru plaques and others had many degenerated neurites possessing paired helical filaments and other accumulated organelles. GSS has been proposed to include cases with progressive ataxia, dementia and massive multifocal plaques in the brain with or without cerebral spongiform changes. The case presented here is a very peculiar case of GSS. Recently, similar cases have been reported in some large families, diagnosed as familial Alzheimer's disease. These cases may be a telencephalic form with numerous NFTs of GSS. 相似文献
10.
Hanibuchi M Yano S Nishioka Y Yanagawa H Miki T Sone S 《Clinical & experimental metastasis》2000,18(5):353-360
The formation of metastases in multiple organs and acquired multi-drug resistance (MDR) are the major obstacles for treatment
of human small-cell lung cancer (SCLC). To explore the possibility of immunological overcoming of multiple-organ metastases
produced by refractory SCLC, we established the MDR variant (SBC-3/DOX), expressing P-glycoprotein, of parental SBC-3 cells
by culturing with gradually increasing concentration of adriamycin. Both SBC-3 and SBC-3/DOX cells expressed a high amount
of ganglioside GM2, an ideal target of SCLC cells. A mouse-human chimeric anti-GM2 monoclonal antibody (KM966) induced antibody-dependent
cellular cytotoxicity (ADCC) mediated by human mononuclear cells (lymphocytes and monocytes) and complement-dependent cytotoxicity
(CDC) mediated by human AB serum against SBC-3/DOX cells to a similar extent compared with parental SBC-3 cells. Pretreatment
of human effector cells with various cytokines induced further enhancement of the KM966-dependent ADCC against SBC-3/DOX cells.
Intravenous injection of SBC-3 or SBC-3/DOX cells into natural killer (NK) cell-depleted severe combined immunodeficient (SCID)
mice developed metastases in multiple organs (liver, kidneys and lymph nodes). Interestingly, SBC-3/DOX cells produced metastases
more rapidly than SBC-3 cells, suggesting more aggressive phenotype of SBC-3/DOX cells than their parental cells in vivo. Systemic treatment with KM966, given on days 2 and 7, drastically inhibited the formation of multiple-organ metastases produced
by both SBC-3 and SBC-3/DOX cells, indicating that KM966 can eradicate metastasis by SCLC cells irrespective of MDR phenotype.
These findings suggest that the mouse-human chimeric KM966 targets the GM2 antigen, and might be useful for the immunological
circumvention of multiple-organ metastases of refractory SCLC.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献