全文获取类型
收费全文 | 335篇 |
免费 | 15篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 19篇 |
妇产科学 | 114篇 |
基础医学 | 55篇 |
口腔科学 | 18篇 |
临床医学 | 22篇 |
内科学 | 34篇 |
皮肤病学 | 3篇 |
神经病学 | 4篇 |
特种医学 | 12篇 |
外科学 | 10篇 |
综合类 | 4篇 |
预防医学 | 6篇 |
药学 | 7篇 |
肿瘤学 | 41篇 |
出版年
2020年 | 4篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 8篇 |
2014年 | 3篇 |
2013年 | 6篇 |
2012年 | 5篇 |
2011年 | 12篇 |
2010年 | 5篇 |
2009年 | 3篇 |
2008年 | 5篇 |
2007年 | 5篇 |
2006年 | 3篇 |
2005年 | 7篇 |
2004年 | 2篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 10篇 |
2000年 | 5篇 |
1999年 | 14篇 |
1998年 | 17篇 |
1997年 | 12篇 |
1996年 | 14篇 |
1995年 | 7篇 |
1994年 | 3篇 |
1993年 | 26篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 9篇 |
1989年 | 22篇 |
1988年 | 9篇 |
1987年 | 11篇 |
1986年 | 5篇 |
1985年 | 10篇 |
1984年 | 3篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1977年 | 4篇 |
1975年 | 6篇 |
1973年 | 2篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1963年 | 1篇 |
1962年 | 2篇 |
1953年 | 1篇 |
排序方式: 共有350条查询结果,搜索用时 531 毫秒
1.
2.
I Gerhard B Vollmar B Runnebaum F Kubli 《European journal of obstetrics, gynecology, and reproductive biology》1987,26(4):303-311
The influence of the weight percentile at birth on childhood development was examined in a prospective study of 847 singleton pregnancies. In the first two years of life significant relationships between the birth weight percentiles and the infant's development could be proven, while at the age of four social factors were predominant. Though various clinical data in pregnancy and delivery were related to fetal growth, such as weight of the mother, previous abortions and diseases, additional biochemical and biophysical information is desirable for early recognition of intrauterine growth disorders. 相似文献
3.
4.
Exposure to wood preservatives containing pentachlorophenol (PCP) was detected in 65 women who consulted the Endocrinological Department of the University Hospital of Obstetrics and Gynecology, Heidelberg, Germany, because of gynecological problems. Blood PCP levels ranged from 20.7 to 133 microg per liter of serum. One hundred and six women with similar clinical conditions, corresponding age and body weight, no PCP exposure in history, and PCP levels below 20 microg per liter of serum served as control group. Significant associations were found between serum PCP concentrations, age, and different parameters of the endocrine system. PCP may act centrally on a hypothalamic or suprahypothalamic level which may result in mild ovarian and adrenal insufficiency. PCP may, therefore, play a role in the increasing infertility problem. 相似文献
5.
Compliance and adverse drug reactions: a prospective study with ethinylestradiol using continuous compliance monitoring 总被引:1,自引:0,他引:1
W. Kruse W. Eggert-Kruse J. Rampmaier B. Runnebaum E. Weber 《Journal of molecular medicine (Berlin, Germany)》1993,71(6):483-487
Summary This study examined the relationship between adverse reactions and patient compliance with ethinylestradiol at 40 g twice daily versus 20 g four times daily. In a randomized study 61 female patients with primary- infertility were prescribed the drug twice daily (n = 31) or four times daily (n = 30). Ethinylestradiol was administered for 7 days before the sperm cervical mucus penetration-test was performed for hormonal standardization of the cervical mucus quality. Drug compliance was measured by continuous monitoring using the Medication Event Monitoring System. Two parameters were evaluated: percentage of prescribed doses taken (administration compliance) and adherence to the prescribed dose schedule (regimen compliance, number of days with two or four dosing events recorded). Adverse drug reactions were assessed using a standardized questionnaire. Fourty-four women experienced side effects, of which 81% were rated by patients as being mild. Patient compliance was higher with the twice daily than with the four times daily regimen: 85% versus 65% prescribed doses taken (P<0.05). There was no significant difference in compliance comparing patients with and without adverse reactions (82% versus 72%, respectively), but compliance was lower and more irregular with at least 3 versus one or two adverse reactions reported: 54% versus 84% in administration compliance and 31% versus 58% in regimen compliance (P<0.05). Compliance was also lower in patients with nausea and vomiting than in those without these symptoms, 59% versus 91% and 34% versus 66% (P<0.005), respectively, and lower with moderate or severe compared to mild side effects; 48% versus 85% and 25% versus 59% (P<0.005). Thus the mere occurrence of side effects was not associated with low compliance. However, the number and nature of symptoms and their intensity as perceived by patients may have considerably influenced drug use behavior.Abbreviations ADR
adverse drug reactions
- SCMPT
sperm cervical mucus penetration-test
Prof. Dr. E. Weber died 7 December 1992 相似文献
6.
Bolontrade MF; Stern MC; Binder RL; Zenklusen JC; Gimenez-Conti IB; Conti CJ 《Carcinogenesis》1998,19(12):2107-2113
In this study we have analyzed the vascular response induced in the two-
stage carcinogenesis model in SENCAR mice. The role of angiogenesis has not
been explored in this model, which is the paradigm of multistage
carcinogenesis and a model for neoplastic lesions derived from exophytic
premalignant lesions (e.g. colon carcinoma, bladder papilloma). We
investigated if angiogenesis is involved in the formation of papillomas and
in the progression from papilloma to carcinoma. To this end we analyzed the
vasculature of normal and hyperplastic skin, focal epidermal hyperplasias
that are precursors of papillomas, papillomas at different stages and
squamous cell carcinomas. We also analyzed the vascularization of
papillomas induced in two strains of mice that differ in their
susceptibility to malignant progression. We show here that angiogenesis is
turned on in the earliest stages of papilloma formation. In late stages,
regardless of state of progression, the predominant response is an increase
in the size of blood vessels. Thus, in the SENCAR mouse model,
representative of exophytic tumors, the angiogenesis switch is a very early
event, probably mechanistically related to the development of the primarily
exophytic lesions. Therefore, the density of blood vessels cannot be used
as a predictor of malignant progression in this model.
相似文献
7.
Josefine Beiersdorf Cornelia Scheungraber Kristina Wunsch Martina Schmitz Alfred Hansel Heike Hoyer Mieczyslaw Gajda Christiane Greinke Ingo B. Runnebaum Matthias Dürst Claudia Backsch 《Genes, chromosomes & cancer》2020,59(3):168-177
A considerable proportion of high grade cervical intraepithelial lesions (CIN2/3) are known to resolve on their own especially among young women. However, since reliable prognostic markers are still lacking, the diagnosis “CIN3” is still an indication for surgery which may result in overtreatment. It is conceivable that a combination of different, ideally independent molecular markers may provide more reliable results. In the present cross‐sectional study two established triage markers, 3q26 amplification and a methylation signature, were evaluated in an age‐dependent manner. The patient cohort comprised 60 patients with histologically confirmed CIN2/3 in two equally sized age groups (<30 years, ≥30 years). Cervical scrapes were analyzed by interphase fluorescence in situ hybridization for 3q26 amplification and methylation specific PCR (GynTect®) for six different genome regions. Both assays showed a significantly different pattern of test outcome independent of age (P = .001). Moreover, the combination of both assays differed significantly for double positive and double negative cases when comparing the two age groups: In patients <30 years there were clearly less cases with positive methylation signature and amplification of 3q26 as in women ≥30 years (23% vs 63%, Bonferroni adjusted P = .016). Of particular interest is the finding that double negative results were exclusive for the young age group (0% vs 27%, Bonferroni adjusted P = .020). Since regression of CIN2/3 characteristically occurs among young women it is tempting to speculate that a double negative test result could be prognostic for regression of CIN2/3. This will have to be investigated further in a prospective longitudinal intervention study. 相似文献
8.
Nicolaus Kristin Zschauer Stefan Bruer Dominik Jimenez-Cruz Jorge Lehmann Thomas Rengsberger Matthias Diebolder Herbert Runnebaum Ingo B. 《Archives of gynecology and obstetrics》2020,301(3):699-706
Archives of Gynecology and Obstetrics - We aimed to assess post-operative complications based on the Clavien–Dindo classification system following routine laparoscopic treatment of all stages... 相似文献
9.
CHARLOTTE ELBERLING ALMASI GUNILLA H
YER‐HANSEN IB JARLE CHRISTENSEN HELLE PAPPOT 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2009,117(10):755-761
Urokinase plasminogen activator (uPA) cleaves its three‐domain cell surface receptor, uPAR, liberating domain I [uPAR(I)] and leaving the cleaved uPAR(II‐III) on the cell surface. Both intact and cleaved uPAR can be shed from the cell surface. uPAR(I) was previously shown to be a prognostic factor in lung tumour extracts. Here we analyse uPAR forms in blood from patients with non‐small cell lung cancer (NSCLC). Preoperatively sampled plasma/serum from 32 patients with NSCLC was analysed. Three time‐resolved fluoroimmunoassays (TR‐FIAs) measuring intact uPAR(I‐III) (TR‐FIA 1), uPAR(I‐III) + uPAR(II‐III) (TR‐FIA 2) and uPAR(I) (TR‐FIA 3) were applied. The Spearman rank correlations between plasma and serum levels of uPAR(I‐III), uPAR(I‐III) + uPAR(II‐III), and uPAR(I) were 0.89, 0.94 and 0.68 respectively. Survival analysis demonstrated that high levels of all uPAR forms were associated with shorter survival. Adjusted for histological subtype high plasma uPAR(I‐III) and uPAR(I) levels as well as serum uPAR(I) levels were significantly associated with shorter OS (hazards ratios = 4.3, 2.8 and 3.8 respectively). High blood levels of intact uPAR and its cleaved forms are associated with poor prognosis in NSCLC. 相似文献
10.
I. Gerhard J. Neumann A. Hege W. Eggert-Kruse H. Minne B. Runnebaum 《Archives of gynecology and obstetrics》1989,245(1-4):945-946
Ohne Zusammenfassung 相似文献