全文获取类型
收费全文 | 5284篇 |
免费 | 659篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 158篇 |
妇产科学 | 261篇 |
基础医学 | 620篇 |
口腔科学 | 146篇 |
临床医学 | 1390篇 |
内科学 | 1101篇 |
皮肤病学 | 94篇 |
神经病学 | 337篇 |
特种医学 | 142篇 |
外科学 | 428篇 |
综合类 | 60篇 |
预防医学 | 498篇 |
眼科学 | 48篇 |
药学 | 210篇 |
中国医学 | 16篇 |
肿瘤学 | 405篇 |
出版年
2023年 | 80篇 |
2022年 | 50篇 |
2021年 | 113篇 |
2020年 | 79篇 |
2019年 | 110篇 |
2018年 | 174篇 |
2017年 | 181篇 |
2016年 | 189篇 |
2015年 | 204篇 |
2014年 | 248篇 |
2013年 | 238篇 |
2012年 | 259篇 |
2011年 | 263篇 |
2010年 | 193篇 |
2009年 | 211篇 |
2008年 | 227篇 |
2007年 | 239篇 |
2006年 | 241篇 |
2005年 | 222篇 |
2004年 | 195篇 |
2003年 | 219篇 |
2002年 | 184篇 |
2001年 | 153篇 |
2000年 | 170篇 |
1999年 | 141篇 |
1998年 | 85篇 |
1997年 | 105篇 |
1996年 | 81篇 |
1995年 | 85篇 |
1994年 | 60篇 |
1993年 | 57篇 |
1992年 | 110篇 |
1991年 | 87篇 |
1990年 | 82篇 |
1989年 | 75篇 |
1988年 | 60篇 |
1987年 | 50篇 |
1986年 | 57篇 |
1985年 | 47篇 |
1984年 | 37篇 |
1983年 | 29篇 |
1982年 | 26篇 |
1981年 | 18篇 |
1980年 | 15篇 |
1979年 | 22篇 |
1978年 | 16篇 |
1976年 | 22篇 |
1975年 | 19篇 |
1970年 | 16篇 |
1966年 | 13篇 |
排序方式: 共有5958条查询结果,搜索用时 990 毫秒
1.
Adjuvant irradiation is the standard treatment after breast conservative surgery. Normofractionated regimen with an overall treatment time of 5 to 6 weeks is often considered as a limiting factor for irradiation compliance. In order to answer this issue, moderate and more recently extreme hypofractionated protocols appeared. We report here oncological outcomes and toxicity of hypofractionated breast irradiation. After defining the frame of moderate and extreme hypofractionated breast irradiations based on overall treatment time, patient selection criteria were listed. According to their levels of proof, the results of moderate and extreme hypofractionated breast irradiation were analysed. Overall treatment time for moderate hypofractionated breast irradiation ranged from 3 to 4 weeks, while for extreme hypofractionated breast irradiation, it was less than 1 week. For moderate hypofractionated breast irradiation, whole breast irradiation was currently performed with or without lymph node irradiation. Moderate hypofractionated breast irradiation has proven to be as safe and as efficient as normofractionated breast irradiation with level IA evidence. For extreme hypofractionated breast irradiation, phase III randomized trials confirmed that accelerated partial breast irradiation was non-inferior in terms of local control compared to normofractionated whole breast irradiation (with external beam radiation therapy and multicatheter brachytherapy), with similar acute and late toxicity. While the use of intraoperative breast irradiation remains under debate, new very accelerated partial breast irradiation (overall treatment time not exceeding 2 days) protocols emerged with encouraging results. Accelerated partial breast irradiation is warranted for extreme hypofractionated breast irradiation and is indicated for low-risk breast cancers. Moderate and extreme hypofractionated breast irradiation regimens are validated and can be routinely proposed according to patient selection criteria. 相似文献
2.
3.
4.
Fluid role boundaries: exploring the contribution of the advanced nurse practitioner to multi‐professional palliative care
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
Alexander Stoff MD ; Angel A. Rivera PhD ; N. S. Banerjee PhD ; J. Michael Mathis PhD ; Antonio Espinosa-de-los-Monteros MD ; Long P. Le PhD ; Jorge I. De la Torre MD ; Luis O. Vasconez MD ; Thomas R. Broker PhD ; Dirk F. Richter MD ; Mariam A. Stoff-Khalili MD ; David T. Curiel MD PhD 《Wound repair and regeneration》2006,14(5):608-617
Genetically modified keratinocytes and fibroblasts are suitable for delivery of therapeutic genes capable of modifying the wound healing process. However, efficient gene delivery is a prerequisite for successful gene therapy of wounds. Whereas adenoviral vectors (Ads) exhibit superior levels of in vivo gene transfer, their transductional efficiency to cells resident within wounds may nonetheless be suboptimal, due to deficiency of the primary adenovirus receptor, coxsackie-adenovirus receptor (CAR). We explored CAR-independent transduction to fibroblasts and keratinocytes using a panel of CAR-independent fiber-modified Ads to determine enhancement of infectivity. These fiber-modified adenoviral vectors included Ad 3 knob (Ad5/3), canine Ad serotype 2 knob (Ad5CAV-2), RGD (Ad5.RGD), polylysine (Ad5.pK7), or both RGD and polylysine (Ad5.RGD.pK7). To evaluate whether transduction efficiencies of the fiber-modified adenoviral vectors correlated with the expression of their putative receptors on keratinocytes and fibroblasts, we analyzed the mRNA levels of CAR, alpha upsilon integrin, syndecan-1, and glypican-1 using quantitative polymerase chain reaction. Analysis of luciferase and green fluorescent protein transgene expression showed superior transduction efficiency of Ad5.pK7 in keratinocytes and Ad5.RGD.pK7 in fibroblasts. mRNA expression of alpha upsilon integrin, syndecan-1 and glypican-1 was significantly higher in primary fibroblasts than CAR. In keratinocytes, syndecan-1 expression was significantly higher than all the other receptors tested. Significant infectivity enhancement was achieved in keratinocytes and fibroblasts using fiber-modified adenoviral vectors. These strategies to enhance infectivity may help to achieve higher clinical efficacy of wound gene therapy. 相似文献
6.
7.
8.
MR compatibility of Guglielmi detachable coils 总被引:6,自引:0,他引:6
9.
Antonio Rivera Antonio Yáñez Gloria León-Tello Constantino Gil Silvia Giono Eduardo Barba Lilia Cedillo 《BMC musculoskeletal disorders》2002,3(1):15-7
Background
Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints. 相似文献10.
BEVERLY HAVENS RN MN MPH INGRID SWENSON RN DPH 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1986,15(5):406-411
Seventy-four 8th- and 10th-grade students attending a private girls' school in Hawaii were queried about their perceptions of and preparation for menstruation using a questionnaire administered in a health education class. Eighty percent had already started menstruating. The most frequently cited perceptions by the respondents referred to both the inconveniences and the normalcy of menstruation. Many were first informed about menstruation by their mothers and stated that they also first informed their mothers when they started menstruating. Surprise, fear, and embarrassment were common initial reactions, while strong negative or positive emotions were more rare. Only 35% wanted boys and girls together during class discussion, but 89% stated that boys needed to be informed about menstruation. The most frequent reasons cited for noncoed settings were the girls' concern about their comfort in openly discussing menstruation. Thirty-eight percent thought parents should inform other siblings when they started menstruation, although almost half gave specific conditions the parents should consider. The majority thought the fifth to sixth grades were the best times to introduce menstruation content. 相似文献