全文获取类型
收费全文 | 133459篇 |
免费 | 9113篇 |
国内免费 | 461篇 |
专业分类
耳鼻咽喉 | 1829篇 |
儿科学 | 3552篇 |
妇产科学 | 2361篇 |
基础医学 | 17118篇 |
口腔科学 | 2546篇 |
临床医学 | 13614篇 |
内科学 | 28418篇 |
皮肤病学 | 1986篇 |
神经病学 | 12770篇 |
特种医学 | 4666篇 |
外国民族医学 | 4篇 |
外科学 | 19108篇 |
综合类 | 2005篇 |
现状与发展 | 1篇 |
一般理论 | 175篇 |
预防医学 | 11758篇 |
眼科学 | 3023篇 |
药学 | 9387篇 |
2篇 | |
中国医学 | 174篇 |
肿瘤学 | 8536篇 |
出版年
2023年 | 492篇 |
2022年 | 728篇 |
2021年 | 2159篇 |
2020年 | 1282篇 |
2019年 | 2100篇 |
2018年 | 2455篇 |
2017年 | 1888篇 |
2016年 | 2070篇 |
2015年 | 2530篇 |
2014年 | 3636篇 |
2013年 | 5573篇 |
2012年 | 8139篇 |
2011年 | 8691篇 |
2010年 | 4900篇 |
2009年 | 4680篇 |
2008年 | 8314篇 |
2007年 | 8879篇 |
2006年 | 8711篇 |
2005年 | 8991篇 |
2004年 | 8572篇 |
2003年 | 8347篇 |
2002年 | 7907篇 |
2001年 | 1538篇 |
2000年 | 1263篇 |
1999年 | 1538篇 |
1998年 | 1814篇 |
1997年 | 1513篇 |
1996年 | 1273篇 |
1995年 | 1263篇 |
1994年 | 1042篇 |
1993年 | 1054篇 |
1992年 | 1088篇 |
1991年 | 1010篇 |
1990年 | 933篇 |
1989年 | 897篇 |
1988年 | 772篇 |
1987年 | 762篇 |
1986年 | 743篇 |
1985年 | 838篇 |
1984年 | 966篇 |
1983年 | 957篇 |
1982年 | 1253篇 |
1981年 | 1113篇 |
1980年 | 1027篇 |
1979年 | 595篇 |
1978年 | 668篇 |
1977年 | 609篇 |
1976年 | 501篇 |
1975年 | 483篇 |
1974年 | 459篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
3.
4.
Timo Rath Lukas Pfeifer Clemens Neufert reas Kremer Moritz Leppkes Arthur Hoffman Markus F Neurath Steffen Zopf 《World journal of gastroenterology : WJG》2020,26(16):1962-1970
BACKGROUND The adenoma detection rate(ADR) is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy. However, adenoma miss rates reach up to 26% and studies have shown that a second inspection of the right colon in retroflected view(RFV) can increase ADR.AIM To assess whether inspection of the whole colon in RFV compared to standard forward view(SFV) can increase ADR.METHODS Patients presenting for screening or surveillance colonoscopy were invited to participate in this randomized controlled trial and randomized into two arms. In RFV arm colonoscopy was initially performed with SFV, followed by a second inspection of the whole colon in RFV. In the SFV arm first withdrawal was performed with SFV, followed by a second inspection of the whole colon again with SFV. Number, size and morphology of polyps found during first and second inspection in each colonic segment were recorded and all polyps were removed and sent for histopathology in separate containers.RESULTS Two hundred and five patients were randomly assigned to the RFV(n = 101) and SFV(n = 104) arm. In the RFV arm, both polyp detection rate(PDR) and ADR were increased under second inspection in RFV(PDR 1~(st) SFV: 39.8%, PDR 2~(nd)RFV: 46.6%; ADR 1~(st) SFV: 35.2%, ADR 2~(nd) RFV: 42%). Likewise, in the SFV arm,PDR and ADR were increased under second inspection(PDR 1~(st) SFV: 37.5%, PDR 2~(nd) SFV: 46.6%; ADR 1~(st) SFV: 34.1%, ADR 2~(nd)SFV: 44.3%) with no significant differences in ADR and PDR between the SFV and RFV arm. Mean number of adenomas per patient(APP) was increased in the RFV and SFV(APP RFV arm: 1~(st) SFV: 1.71; 2~(nd) RFV: 2.38; APP SFV arm: 1~(st) SFV: 1.83, 2~(nd)SFV:2.2). The majority of adenomas additionally found during second inspection in RFV or in SFV were located in the transverse and left-sided colon and were 5 mm in size.CONCLUSION Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and RFV. Hence, increased detection is most likely a feature of the second inspection itself but not of the inspection mode. 相似文献
5.
6.
7.
8.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献9.