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Ughetto Stefano Migliore Cristina Pietrantonio Filippo Apicella Maria Petrelli Annalisa D&#;Errico Laura Durando Stefania Moya-Rull Daniel Bellomo Sara E. Rizzolio Sabrina Capel&#;a Tania Ribisi Salvatore Degiuli Maurizio Reddavid Rossella Rapa Ida Fumagalli Uberto De Pascale Stefano Ribero Dario Baronchelli Carla Sgroi Giovanni Rausa Emanuele Baiocchi Gian Luca Molfino Sarah Manenti Stefania Bencivenga Maria Sacco Michele Castelli Claudia Siena Salvatore Sartore-Bianchi Andrea Tosi Federica Morano Federica Raimondi Alessandra Prisciandaro Michele Gloghini Annunziata Marsoni Silvia Sottile Antonino Sarotto Ivana Sapino Anna Marchi&#; Caterina Cassoni Paola Guarrera Simonetta Corso Simona Giordano Silvia 《Gastric cancer》2021,24(4):897-912
Gastric Cancer - Trastuzumab is the only approved targeted therapy in patients with HER2-amplified metastatic gastric cancer (GC). Regrettably, in clinical practice, only a fraction of them... 相似文献
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Haemangiomas are tumours of vascular origin accounting for approximately 7 % of all benign tumours. Three types of haemangioma have been described according to the vessel type involved: capillary, cavernous and mixed. Intramuscular haemangiomas (IMHs) are infrequent, accounting for less than 1 % of all haemangiomas and are mostly located in the extremities and the trunk. Intramuscular haemangiomas of the rectus abdominis muscle are extremely rare, with only one previous case reported in the literature to the best of our knowledge. In this report, we present the case of a patient with intractable pain related to IMHs of the rectus abdominis and we analyse diagnostic assessment and surgical management of the condition. 相似文献
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Alberto Arezzo Mauro Verra Rossella Reddavid Francesca Cravero Marco Augusto Bonino Mario Morino 《Surgical endoscopy》2012,26(11):3330-3333
Background
Colorectal postsurgical leaks and fistulas are severe complications that dramatically increase morbidity and mortality. The aim of this study was to evaluate the clinical impact of over-the-scope clip (OTSC) closure to seal the visceral wall in the management of acute and chronic colorectal postsurgical leaks and fistulas.Methods
We reviewed our prospective series of acute and chronic colorectal postsurgical leaks and fistulas observed between April 2008 and September 2011 and treated by OTSC. Indications were all cases with an orifice <15?mm in maximum diameter with no extraluminal abscess and luminal stenosis.Results
Endoscopic OTSC closure was performed in 14 consecutive patients (mean defect?=?9.1?mm in diameter) by means of 10.5- or 12-mm clips, depending on the wall defect diameter. In eight cases, the indication was an acute leak and in six cases a chronic leak, mainly after anterior rectal resection; two cases were complicated by a rectovaginal fistula and in two other cases by a colocutaneous fistula. OTSC treatment was used to complete endoscopic vacuum-assisted closure of a large defect in three cases. The overall success rate was 86?% (12/14): 87?% (7/8) in acute and 83?% (5/6) in chronic cases. No OTSC-related complications occurred. Further surgery was required in one case.Conclusion
Endoscopic OTSC closure of colorectal postsurgical leaks and fistulas is a safe technique, with a high success rate in both acute and chronic cases, including rectovaginal and colocutaneous fistulas. 相似文献5.
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Maurizio Degiuli Simone Arolfo Andrea Evangelista Laura Lorenzon Rossella Reddavid Carlo Staudacher Paola De Nardi Riccardo Rosati Ugo Elmore Claudio Coco Gianluca Rizzo Claudio Belluco Marco Forlin Marco Milone Giovanni Domenico De Palma Daniela Rega Paolo Delrio Mario Guerrieri Mario Morino 《European journal of surgical oncology》2018,44(8):1233-1240
Introduction
We retrospectively investigated the impact of number or complete absence of nodes retrieved on survival of patients with rectal cancer (RC) treated with neoadjuvant radiation-therapy (NAT).Methods
All patients with RC treated with NAT followed by curative surgery from 2000 to 2014 in 14 Italian referral Centres for Colorectal Surgery were enrolled. Information about number of nodes harvested, node ratio, type of radiation therapy schedule and tumour stage were recorded. Impact of number or complete absence of nodes retrieved on overall survival (OS) and on cumulative incidence of death for disease (CIDD) was assessed and factors influencing node yield were investigated.Results
In total, 1407 patients were included. Mean number of nodes retrieved was 12.9, while no lymph nodes were found in only 32 patients (2%, ypNnull). Definite nodal stage was ypN0 in 1001 patients (71%) and ypN+ in 372 patients (27%). In multivariable analysis ypNnull patients showed worse OS and CIDD compared to both ypN0 and ypN+. In ypN0 patients, number of nodes assessed, stratified in 4 groups (<5, 5–10, 11–15 and > 15), did not significantly influence OS and CIDD. Long-course radiation schedule and early T stages negatively affected node assessment.Conclusion
Complete absence of nodes assessed was associated with worse prognosis compared to node-negative and node-positive patients. In node-negative patients number of nodes was not associated to OS and CIDD. Based on data from this large population of irradiated RC, number of nodes assessed has no prognostic impact in node-negative patients. 相似文献8.
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