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排序方式: 共有294条查询结果,搜索用时 15 毫秒
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Patient experience with, and use of, an electronic monitoring system to assess vaccination responses
Stuart S. Olmsted PhD John D. Grabenstein RPh PhD † Arvind K. Jain MS ‡ Nicole Lurie MD MSPH § 《Health expectations》2006,9(2):110-117
OBJECTIVE: To evaluate the user experience and acceptability of an electronic patient monitoring system. SETTING AND PARTICIPANTS: 822 Military and civilian personnel at a health clinic at a major US military headquarters used an Internet and telephone-based electronic monitoring system to report vaccination-site responses and symptoms after receiving the smallpox vaccination. Focus groups of vaccinees were conducted to help develop a survey about the experience that was distributed to 379 vaccinees (96% completion rate). RESULTS: Users of the electronic monitoring system reported that it was fast and easy to use and reported they would use a system like this again and recommend an electronic monitoring system to a friend or relative. Most users (84%) were comfortable with a physician tracking their vaccine reaction using their electronic reports, but only half (51%) were comfortable with eliminating the post-vaccination follow-up visit with their health-care provider based on their electronic reports. CONCLUSIONS: This electronic monitoring system was well received by vaccinees and allowed health-care providers to track the status of vaccinees. However, vaccinees were not comfortable replacing a physician visit with electronic monitoring, at least for the smallpox vaccination. A monitoring system like this may be useful in public health settings, such as mass vaccination or prophylaxis during a bioterrorism event, a pandemic influenza outbreak, or another public health emergency. 相似文献
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Chewing Gum Headaches 总被引:2,自引:0,他引:2
Aspartame, a popular dietetic sweetener, may provoke headache in some susceptible individuals. Herein, we describe three cases of young women with migraine who reported their headaches could be provoked by chewing sugarless gum containing aspartame. 相似文献
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M. L. Strong BS RPh L. J. Schaaf PhD M. C. Pankaskie PhD D. H. Robinson PhD 《Journal of clinical pharmacy and therapeutics》1994,19(6):361-369
Published reports regarding the stability of morphine are at variance, especially in syringes used in patient-controlled analgesia (PCA) devices. In addition to the effects of container type and vehicle, reasons for this variation include the effect of excipients temperature and light during storage. Furthermore, the literature varies regarding the mechanisms of decomposition for morphine. To our knowledge, the stability of meperidine (pethidine) stored in plastic syringes has not been reported. The purposes of this study were to investigate the stability of morphine sulphate (1 and 5 mg/ml) and meperidine hydrochloride (5 and 10 mg/ml) in plastic syringes for use in PCA devices for a duration of 12 weeks, and evaluate the influence of light (240 foot-candies), temperature (-20, 4 and 23d?C), diluent (5% dextrose or normal saline), and drug concentration on the stability of these narcotic analgesics. Samples were taken bi-weekly for solutions protected from light and weekly for solutions exposed to light. Morphine sulphate and meperidine hydrochloride concentrations were quantified using independent, stability-indicating, high performance liquid chromatographic assays. The within-day and between-day coefficients of variation for these assays were 4% over each of the concentration ranges studied. Under the conditions of this study, it is proposed that although decomposition of morphine to its main product, pseudomorphine, can be interpreted using first-order kinetics, consecutive (to form the N-oxide) and parallel mechanisms (to form apomorphine) exist. Morphine solutions were more stable in normal saline than in 5% dextrose. SheIf-life data indicate that morphine is stable for at least 6 weeks when protected from light. Exposure to light accelerates morphine decomposition two to six-fold depending on the concentration, and the shelf-life is reduced to about 1 week in some instances. Meperidine solutions in both vehicles under all conditions had shelf-lives of at least 12 weeks. No effects of light were detected and no changes in solution colour were observed. This study illustrates that patients using PCA devices must be advised about shelf-lives as well as correct storage conditions to protect solutions of these drugs from environmental factors that may alter shelf-lives. Pharmacists should also note that other formulation factors such as: antioxidants, preservations, buffers, impurities, and the source and quality of containers, may significantly alter the shelf-lives of these drugs. 相似文献
5.
Daniel L. Hamilos MD John J. Oppenheimer MD Harold S. Nelson MD Sally Wenzel MD Sue Driscoll RN Richard F. Lockey MD David B. K. Golden MD Leland Fan MD Ralph J. Sanks RPh S. Allen Bock MD John W. Yunginger MD Donald Stevenson MD Timothy Sullivan MD Thomas Corbridge MD 《The Journal of allergy and clinical immunology》1993,91(6)
These guidelines are intended to reduce the potential for serious or life-threatening reactions when clinical research is conducted. The following issues were addressed: identifying the risks involved in the research, providing adequate safeguards in the protocol design and during withholding of medication, anticipating risks, minimizing the chances for human error, providing resuscitative equipment sufficient to deal with the most serious anticipated life-threatening reactions, planning for medical support in case of a life-threatening emergency, and optimizing the use of medical personnel and expertise to handle emergency situations. The guidelines also discuss important general issues about protocol design and implementation and the human subject consent form, which should facilitate the approval of protocols by the governing institutional review board.The guidelines are not meant to be inflexible or applicable to all research situations. However, it is our hope that they will allow for clinical research to be conducted in a manner that affords the research subjects a high degree of protection from unnecessary and possibly fatal injuries. 相似文献
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Comparing standard care with a physician and pharmacist team approach for uncontrolled hypertension 总被引:2,自引:1,他引:2
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Dr. Paul E. Bogden MD Robert D. Abbott PhD Pam Williamson PharmD Janet K. Onopa MD Leann M. Koontz RPh 《Journal of general internal medicine》1998,13(11):740-745
OBJECTIVE: To assess the effect of a physician and pharmacist teamwork approach to uncontrolled hypertension in a medical resident teaching
clinic, for patients who failed to meet the recommended goals of the fifth Joint National Commission on Detection, Evaluation
and Treatment of High Blood Pressure.
HYPOTHESIS: Physician and pharmacist teamwork can improve the rate of meeting national blood pressure goals in patients with previously
uncontrolled hypertension.
DESIGN: A single-blinded randomized controlled trial lasting 6 months.
SETTING: A primary care outpatient teaching clinic.
PATIENTS: A sample of 95 adult hypertensive patients who failed to meet national blood pressure goals based on three consecutive visits
over a 6-month period.
INTERVENTION: Patients were randomly assigned to a control arm of standard medical care or to an intervention arm in which a physician
and pharmacist worked together as a team.
MAIN RESULTS: At study completion, the percentage of patients achieving national goals due to intervention was more than double the percentage
in the control arm (55% vs 20%, p < .001). Systolic blood pressure declined 23 mm Hg in the intervention arm versus 11 mm Hg in the control arm (p < .01). Diastolic blood pressure declined 14 and 3 mm Hg in the intervention and control arms, respectively (p < .001). The intervention worked equally as well in men and women and demonstrated noticeable promise in a minority of mixed-ancestry
Hawaiians in whom hypertension is of special concern.
CONCLUSIONS: Patients who fail to achieve national blood pressure goals under standard outpatient medical care may benefit from a program
that includes a physician and pharmacist teamwork approach.
The views expressed in this article are those of the authors and do not reflect the official policy or position of the Queen’s
Medical Center.
This work was supported by a grant from the Queen’s Medical Center, Honolulu, Hawaii and by a Research Centers in Minorities
Institutions Award (P20 RR 11091) from the National Institutes of Health. 相似文献