全文获取类型
收费全文 | 49748篇 |
免费 | 4877篇 |
国内免费 | 2542篇 |
专业分类
耳鼻咽喉 | 392篇 |
儿科学 | 794篇 |
妇产科学 | 661篇 |
基础医学 | 6580篇 |
口腔科学 | 1283篇 |
临床医学 | 5110篇 |
内科学 | 8257篇 |
皮肤病学 | 808篇 |
神经病学 | 3703篇 |
特种医学 | 2078篇 |
外国民族医学 | 8篇 |
外科学 | 6366篇 |
综合类 | 6086篇 |
现状与发展 | 2篇 |
一般理论 | 9篇 |
预防医学 | 3264篇 |
眼科学 | 1159篇 |
药学 | 4954篇 |
11篇 | |
中国医学 | 1814篇 |
肿瘤学 | 3828篇 |
出版年
2023年 | 362篇 |
2022年 | 893篇 |
2021年 | 1222篇 |
2020年 | 947篇 |
2019年 | 1054篇 |
2018年 | 1284篇 |
2017年 | 1134篇 |
2016年 | 1160篇 |
2015年 | 1505篇 |
2014年 | 1859篇 |
2013年 | 2092篇 |
2012年 | 2806篇 |
2011年 | 2971篇 |
2010年 | 2009篇 |
2009年 | 1727篇 |
2008年 | 2336篇 |
2007年 | 2479篇 |
2006年 | 2152篇 |
2005年 | 1839篇 |
2004年 | 1681篇 |
2003年 | 1691篇 |
2002年 | 1515篇 |
2001年 | 2887篇 |
2000年 | 2659篇 |
1999年 | 2150篇 |
1998年 | 887篇 |
1997年 | 634篇 |
1996年 | 472篇 |
1995年 | 393篇 |
1994年 | 339篇 |
1993年 | 297篇 |
1992年 | 1075篇 |
1991年 | 955篇 |
1990年 | 860篇 |
1989年 | 928篇 |
1988年 | 843篇 |
1987年 | 773篇 |
1986年 | 719篇 |
1985年 | 626篇 |
1984年 | 398篇 |
1983年 | 323篇 |
1982年 | 187篇 |
1981年 | 139篇 |
1980年 | 118篇 |
1979年 | 207篇 |
1973年 | 93篇 |
1972年 | 93篇 |
1971年 | 97篇 |
1970年 | 83篇 |
1968年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Yuxiang Ma Wenfeng Fang Hongyun Zhao Sai Praneeth Bathena Amol Tendolkar Jennifer Sheng Li Zhang 《The oncologist》2021,26(4):e549-e566
Lessons Learned
- The overall safety profiles of ipilimumab 3 mg/kg and 10 mg/kg administered every 3 weeks, were consistent between Chinese patients with solid tumors in the current study and patients from previous U.S. ipilimumab monotherapy studies. No new safety signals were identified.
- The mean systemic exposures to ipilimumab (assessed by first dose area under the curve during the dosing interval and maximum serum concentration) were numerically lower in the Chinese patient population than in U.S. patients for both 3 mg/kg and 10 mg/kg doses; however, the range of serum concentrations in the Chinese and U.S. populations overlapped (3 mg/kg and 10 mg/kg), suggesting that ipilimumab pharmacokinetics was ethnically insensitive in this study.
2.
3.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations. 相似文献
4.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
目前新型冠状病毒肺炎(COVID-19)疫情在全球蔓延,形势严峻,并对全球公共卫生事业构成巨大挑战,快速准确的诊断COVID-19对疫情的防控有重要意义。本文报道1例COVID-19患者的调查和确诊过程,以对COVID-19确诊和疫情防控提供有价值的参考。患者为赴渝务工于2020年1月23日返乡人员,在渝期间,其同工地的一同事确诊为COVID-19,之后该工地接连有另外8位同事被确诊。患者返乡后2月2日被当地疫情防控单位采取医学隔离。患者于隔离后不久出现咳嗽,阵发性,干咳为主,偶可咳出黄色痰液等COVID-19相关临床症状,遂被当地新型冠状病毒肺炎定点医疗单位收治,后经市级新型冠状病毒肺炎诊治专家组远程视频会诊转入四川大学华西医院资阳医院。患者先后经历9次核酸检测,在前8次核酸检测均为阴性的情况下,于第9次核酸检测结果为阳性,2月21日最终确诊为新型冠状病毒肺炎。 相似文献
6.
L.‐Q. Zheng X.‐C. Han Y. Huang H.‐W. Li X.‐D. Niu J. Li 《Clinical and experimental dermatology》2015,40(3):293-297
Porocarcinoma is an unusual, locally aggressive and potentially fatal neoplasm. Several cutaneous malignancies have been described in association with porocarcinoma, including squamous cell carcinoma, basal cell carcinoma and tricholemmal carcinoma. Previous reports have indicated that the occurrence of malignant tumours in combination with porocarcinoma is extremely rare, in particular with regard to Bowen disease (BD). We report an uncommon case of porocarcinoma occurring synchronously in a single BD lesion in a 63‐year‐old woman with multiple BD lesions. The clinical and histological findings confirmed this diagnosis. 相似文献
7.
8.
F. Giovanardi F. Nudo Q. Lai M. Garofalo A. Consolo E. Choppin De Janvry G.A. Arroyo Murillo P. Ursi D. Stabile F. Melandro P.B. Berloco R. Pretagostini L. Poli 《Transplantation proceedings》2019,51(1):128-131
Background
Arterial vascular anomalies in patients undergoing kidney transplantation (KT) are correlated with a higher incidence of early surgical complications, potentially causing graft loss. Arterial reconstruction allows patients to overcome these surgical challenges, thus minimizing the risk of poor outcomes. The aim of the present study is to retrospectively investigate the safety and effectiveness of the multiple arterial reconstruction technique with a Teflon patch in case of an unavailable aortic patch: to do so, surgical complications, graft function, and patient survival were evaluated.Methods
During the period January 2009 to August 2016, 202 adult deceased-donor KTs were performed at our center. Group A (n = 27; reconstruction of multiple arteries) and Group B (n = 175; control group) were compared.Results
No differences were observed between the 2 groups in terms of early postoperative course, with no vascular complication observed in Group A. No vascular patch infections were reported, nor longer cold ischemia time rates. Similarly, long-term survival rates were similar between the 2 groups.Conclusions
The Teflon-patch arterial reconstruction technique appears to be safe and effective, with an acceptable balance of benefits and potential risks of using a prosthetic material. Studies based on larger series are needed to further validate this approach. 相似文献9.
10.