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排序方式: 共有81条查询结果,搜索用时 31 毫秒
1.
Maria P Villela Vanessa L Andrade Bryelle Eccard Alceu A Jordão Jonas T Sertório Jose E Tanus‐Santos Ieda FO Silva Josianne N Silveira Valéria C Sandrim 《Clinical and experimental pharmacology & physiology》2014,41(10):744-747
Higher homocysteine (Hcy) levels are associated with cardiovascular risk. The aim of the present study was to evaluate the effect of simvastatin treatment on circulating Hcy levels in obese women without hypertension, diabetes or dyslipidaemia; and to determine whether the 677C>T polymorphism located in methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene modulates the effects of this treatment on Hcy and nitrite (as a biomarker of nitric oxide (NO) bioavailability). Twenty‐five obese women (body mass index ≥ 30 kg/m2) who had received 20 mg/day simvastatin for 6 weeks were enrolled in the study. Venous blood samples were collected to measure plasma biomarkers and gene polymorphisms. Simvastatin treatment significantly reduced total cholesterol, low‐density lipoprotein–cholesterol, thiobarbituric acid‐reactive substances, high‐sensitivity C‐reactive protein and Hcy, whereas nitrite levels were increased. The reduction in Hcy levels in carriers of the T allele was ?20.3% compared with –9.4% in patients with the CC genotype. Importantly, before treatment, nitrite levels were significantly higher in patients with the CC genotype compared with T allele carriers, whereas after treatment these levels were similar between groups. Our findings demonstrate that obese women without comorbidities and carrying the T variant of the 677C>T polymorphism of MTHFR exhibit benefits with simvastatin treatment, mainly in terms of increased NO levels. 相似文献
2.
Huseyin Celik Ozlem Celik Volkan Inal Fulya Oz Puyan Armagan Tugrul 《Renal failure》2014,36(1):104-107
Rhabdomyolysis ranges from an asymptomatic illness with elevated creatine kinase levels to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure, and disseminated intravascular coagulation. The most common causes are crush injury, overexertion, alcohol abuse, certain medicines, and toxic substances. A number of electrolyte abnormalities and endocrinopathies, including hypothyroidism, thyrotoxicosis, diabetic ketoacidosis, nonketotic hyperosmolar state, and hyperaldosteronism, cause rhabdomyolysis. Rhabdomyolysis and acute renal failure are unusual manifestations of pheochromocytoma. There are a few case reports with pheochromocytoma presenting rhabdomyolysis and acute renal failure. Herein, we report a case with pheochromocytoma crisis presenting with rhabdomyolysis and acute renal failure. 相似文献
3.
4.
Tulin Yalta G. Kazındır F. Oz Puyan E. Tastekin U. Usta T. Ciftci A. Kutlu 《The African Journal of Urology》2010,16(4):132-133
A 9-year old male patient was admitted to our clinic for circumcision. Physical examination revealed a mass in the prepuce.
After excision of the mass, histopathological examination was consistent with a mucoid cyst of the penile skin, which has
been rarely reported. Pathologists and clinicians dealing with genitourinary system pathology should be familiar with this
rarely encountered entity. 相似文献
5.
Canthaxanthin induces apoptosis in human cancer cell lines 总被引:3,自引:1,他引:2
Palozza P; Maggiano N; Calviello G; Lanza P; Piccioni E; Ranelletti FO; Bartoli GM 《Carcinogenesis》1998,19(2):373-376
To investigate the possibility that canthaxanthin inhibits cancer cell
growth by inducing apoptosis, human WiDr colon adenocarcinoma and SK- MEL-2
melanoma cells were treated with two different doses of the carotenoid for
48 h. Canthaxanthin was incorporated and/or associated to cells. The
treatment with the carotenoid caused growth inhibition in both cell types.
Concomitantly, apoptosis was induced. Increasing time of exposure and
carotenoid concentration, this effect was more pronounced. At 48 h, the
percentages of apoptotic cells were 13 and 15, using 1 microM
canthaxanthin, and 18 and 20, using 10 microM canthaxanthin in WiDr and
SK-MEL-2 cells, respectively. This study represents the first demonstration
that canthaxanthin is able to induce apoptosis in tumour cells.
相似文献
6.
7.
Normal and stenotic renal arteries: experimental balloon-expandable intraluminal stenting 总被引:2,自引:0,他引:2
Palmaz JC; Kopp DT; Hayashi H; Schatz RA; Hunter G; Tio FO; Garcia O; Alvarado R; Rees C; Thomas SC 《Radiology》1987,164(3):705-708
Elastic recoil of the vessel wall is a common cause of failure of percutaneous transluminal angioplasty in renal arteries. To oppose such recoil, balloon-expandable metal stents were implanted in artificially stenotic renal arteries in pigs and normal renal arteries in dogs and pigs. The stents were then examined angiographically and histologically at regular intervals. All stents were completely covered with endothelialized neointima in 3 weeks. There was no difference in intimal thickness between the stenotic and nonstenotic renal arteries. A large stent diameter and a large open or nonmetal surface may cause less intimal hyperplasia, but nonturbulent, fast arterial flow is probably the most important factor in ensuring long-term patency of the vessel. 相似文献
8.
The porcine reproductive and respiratory syndrome virus (PRRSV) has three major structural proteins which designated as GP5,
M, and N. Protein GP5 and M have been considered very important to arouse the humoral and cellular immune responses against
PRRSV infection and proposed to be the excellent candidate proteins in the design of PRRS bioengineering vaccine. There were
some attempts on expressing GP5 or M in DNA vaccine and adenovirus to arouse humoral and cellular immune responses, but few
papers have been reported on that the immune response can be difference because of the expression patterns of GP5 and M proteins
in the recombinant virus. In this article, four recombinant viruses that expressed GP5 and M proteins of PRRSV in the modified
vaccinia virus ankara (MVA) with different expression patterns were made. In these recombinant virus (rMVAs), GP5 and M proteins
were expressed in MVA in the same virus but under the control of two promoters (rMVA-GP5/M), or as a fusion protein under
one promoter (rMVA-GP5-M), or separately (rMVA-GP5 and rMVA-M). The humoral and cellular immune responses for the four recombinant
viruses were evaluated with mouse model. Every mouse was inoculated with 5 × 105 TCID50 of the different rMVAs and boosted 3 weeks later. Neutralizing antibody titers for each group were detected with virus neutralization
test assay weekly after the primary inoculation for 13 weeks to evaluate the humoral immune response. The production of gamma
interferon (IFN-γ), interleukin-2 (IL-2), and interleukin-4 (IL-4) was detected in splenocytes of rMVA-inoculated mice at
30, 60, and 90 days post inoculation to evaluate the cellular immune response. Results showed that rMVA-GP5 and rMVA-M cannot
induce obvious humoral and cellular immune responses; rMVA-GP5-M inoculated group developed better immune responses than rMVA-GP5
and rMVA-M inoculated groups; however, mice inoculated with rMVA-GP5/M maintained the strongest cellular response against
PRRS and consistently enhanced the anti-PRRSV humoral responses. The strategy of co-expressing PRRSV GP5 and M protein in
MVA under the control of different promoters might be an attractive method for future PRRSV vaccine design.
Co-first authors have same contribution for this article. 相似文献
9.
目的:测试并分析脾胃虚寒型慢性萎缩性胃炎(chronic atrophic gastritis, CAG)患者胃经穴位的电阻值,总结疾病状态下胃经的虚实状况,用以指导针灸临床治疗。方法收集2010年1月-2013年12月中国人民解放军第306医院中医科83例脾胃虚寒型CAG患者,应用体表电阻测量法测定双侧胃经厉兑、内庭、陷谷、冲阳、解溪、丰隆、足三里、梁丘穴电阻,以穴位向外侧旁开1 cm处作为非穴区电阻对照点。采用朱氏耳廓全息检测仪,在每个穴位测量点(约0.5 cm2)自动检测20个点的电阻,以平均电阻值作为该穴的电阻值。结果冲阳穴左侧电阻值为(9.64±2.03)k?,右侧电阻值为(9.68±2.02)k?,显著低于同侧其他穴位(P<0.01);梁丘穴左侧电阻值为(13.44±2.11)k?,右侧电阻值为(13.68±2.12)k?,显著高于同侧其他穴位(P<0.01)。结论脾胃虚寒型CAG患者胃经穴位电阻值不同,体现了胃经诸穴的不同虚实状况和本病脾胃虚弱为本、气滞血瘀为标的基本病机。 相似文献
10.
E Benlier S Eskiocak FO Puyan EY Sikar H Kandulu IK Omurlu H Top AC Aygit 《Annals of plastic surgery》2012,69(2):152-156
Electrical injuries induce progressive tissue loss. We evaluated the effect of lidocaine on tissue necrosis after electrical burn injuries. Forty-two male Wistar albino rats (250-300 g) were divided into 3 groups [Group A (n=6), control group without an electrical burn injury; and Groups B (n=18) and C (n=18), electrical burn injury groups without and with lidocaine therapy, respectively]. Three separate analyses were performed at different time points on 6 of 18 rats from Groups B and C at each time point. Electrical burns were induced by applying 220 V AC between the left upper and right lower extremities for 10 seconds. Myeloperoxidase and malondialdehyde levels were measured in skin and muscle biopsy specimens after the first hour, fresh and dry weight differences in the amputated extremities were calculated after 24 hours, and live and necrotic tissue areas were measured at 7 days after burn injury. We found that lidocaine reduced edema, the number of neutrophils, and neutrophil damage in tissues. We conclude that lidocaine decreased the amount of necrotic tissue caused by electric injury. 相似文献