排序方式: 共有10条查询结果,搜索用时 15 毫秒
1
1.
Sarunthorn Lapkittichot Prakasit Chirappapha Naparat Rermluk 《Radiology Case Reports》2022,17(4):1110
Accessory breast tissue is an anatomical variation which occurs during embryogenic development. It appears most frequently at the axilla. Benign and malignant processes in general breast tissue can occur in accessory breast tissue. We report a case of 76-year-old female presented with palpable, huge mass at the right axilla which pathology of the mass was borderline phyllodes tumor. Phyllodes tumors arising in accessory breast tissue is an extremely rare condition. And this case study showed more detail on phyllodes tumor which would encourage the advance in management of the disease. 相似文献
2.
Adinun Apivatgaroon Chayanin Angthong Prakasit Sanguanjit Bancha Chernchujit 《Disability and rehabilitation》2016,38(21):2161-2164
Purpose: To develop a Thai version of the Kujala score and show the evaluation of the validity and reliability of the score.Method: The Thai version of the Kujala score was developed using the forward–backward translation protocol. The 49 PFPS patients answered the Thai version of questionnaires including the Kujala score, Short Form-36 (SF-36) and International Knee Documentation Committee (IKDC) Subjective Knee Form. The validity between the scores has been tested. The reliability was assessed using test–retest reliability and internal consistency.Results: The Thai version of the Kujala score showed a good correlation with Thai IKDC Subjective Knee Form (Pearson’s correlation coefficient; r?=?0.74: p?0.01) and moderate correlation with the Thai SF-36 subscales of physical component summary, total score and role physical (r?=?0.586, 0.571 and 0.524, respectively: p?0.01). The test–retest reliability was excellent with an intra-class correlation coefficient of 0.908 (p?0.001; 95% CI [0.842–0.947]). The internal consistency was strong with Cronbach’s alpha of 0.952 (p?0.001). No floor and ceiling effects were observed.Conclusion: The Thai version of the Kujala score has shown good validity and reliability. This score can be effectively used for evaluating Thai patients with patellofemoral pain syndrome.
- Implications for Rehabilitation
The Kujala score is a self-administered questionnaire for patients with patellofemoral pain syndrome (PFPS).
The validity and reliability of the Thai version of Kujala are compatible with other versions (Turkish, Chinese and Persian version).
The Thai version of Kujala has been shown to have validity and reliability in Thai PFPS patients and can be used for clinical evaluation and also in the research work.
3.
Narisorn Kongruttanachok Chutipa Phuangphairoj Araya Thongnak Wanpen Ponyeam Prakasit Rattanatanyong Wichai Pornthanakasem Apiwat Mutirangura 《Molecular cancer》2010,9(1):1-14
Background
Cancer cells utilize a variety of mechanisms to evade immune detection and attack. Effective immune detection largely relies on the formation of an immune synapse which requires close contact between immune cells and their targets. Here, we show that MUC16, a heavily glycosylated 3-5 million Da mucin expressed on the surface of ovarian tumor cells, inhibits the formation of immune synapses between NK cells and ovarian tumor targets. Our results indicate that MUC16-mediated inhibition of immune synapse formation is an effective mechanism employed by ovarian tumors to evade immune recognition.Results
Expression of low levels of MUC16 strongly correlated with an increased number of conjugates and activating immune synapses between ovarian tumor cells and primary naïve NK cells. MUC16-knockdown ovarian tumor cells were more susceptible to lysis by primary NK cells than MUC16 expressing controls. This increased lysis was not due to differences in the expression levels of the ligands for the activating receptors DNAM-1 and NKG2D. The NK cell leukemia cell line (NKL), which does not express KIRs but are positive for DNAM-1 and NKG2D, also conjugated and lysed MUC16-knockdown cells more efficiently than MUC16 expressing controls. Tumor cells that survived the NKL challenge expressed higher levels of MUC16 indicating selective lysis of MUC16low targets. The higher csMUC16 levels on the NKL resistant tumor cells correlated with more protection from lysis as compared to target cells that were never exposed to the effectors.Conclusion
MUC16, a carrier of the tumor marker CA125, has previously been shown to facilitate ovarian tumor metastasis and inhibits NK cell mediated lysis of tumor targets. Our data now demonstrates that MUC16 expressing ovarian cancer cells are protected from recognition by NK cells. The immune protection provided by MUC16 may lead to selective survival of ovarian cancer cells that are more efficient in metastasizing within the peritoneal cavity and also at overcoming anti-tumor innate immune responses. 相似文献4.
Tangkijvanich P Hourpai N Rattanatanyong P Wisedopas N Mahachai V Mutirangura A 《Clinica chimica acta; international journal of clinical chemistry》2007,379(1-2):127-133
BACKGROUND: We investigated the clinical implications of global hypomethylation, one of the most consistent epigenetic changes in cancer, in the sera of patients with hepatocellular carcinoma (HCC). METHODS: Combined bisulfite restriction analysis PCR was used to assess the methylation status of LINE-1 repetitive sequences in genomic DNA derived from sera of 85 patients with HCC, 73 patients with cirrhosis, 20 healthy carriers of hepatitis B virus (HBV) and 30 healthy controls. RESULTS: Serum genome hypomethylation, the percentage of unmethylated LINE-1, was significantly increased in patients with HCC (P<0.001). The levels of serum LINE-1 hypomethylation at initial presentation correlated significantly with the presence of HBsAg, large tumor sizes, and advanced tumor stages classified by the CLIP score. Multivariate analyses showed that serum LINE-1 hypomethylation was a significant and independent prognostic factor of overall survival. CONCLUSION: Serum LINE-1 hypomethylation may serve as a prognostic marker for patients with HCC. 相似文献
5.
6.
Effectiveness and reliability of sentinel lymph node biopsy under local anesthesia for breast cancer
The objective of the present study was to determine the effectiveness and reliability of sentinel lymph node biopsy (SLNB) performed under local anesthesia (LA) for patients with breast cancer, by comparing the results with those obtained under general anesthesia (GA). Between January 2006 and February 2007, SLNB was performed under LA or GA in 37 and 94 patients with clinical Tis, T1, T2 or T3 N0 breast cancer, respectively. All underwent radiocolloid and blue dye injections to identify sentinel nodes. The sentinel node detection rate, the number of nodes harvested and the number of positive nodes were compared between the two groups. The sentinel node identification rates were similar for both groups. The number of sentinel and axillary nodes removed and number of positive nodes did not differ significantly between the two groups. SLNB performed under LA is an effective and reliable alternative to SLNB done under GA. 相似文献
7.
8.
McFarland EG Sanguanjit P Tasaki A Keyurapan E Fishman EK Fayad LM 《Skeletal radiology》2006,35(7):488-496
Background The reverse shoulder prosthesis is a prosthesis that has been in clinical use in Europe since 1985 and was approved for use in the United States in 2004. This unique prosthesis has a baseplate attached to the glenoid, which holds a spherical component, while the humeral component includes a polyethylene insert that is flat. This design is the “reverse” configuration of that seen with a conventional arthroplasty, in which the spherical component is part of the humeral component. The indications for the reverse prosthesis are: (1) painful arthritis associated with irreparable rotator cuff tears (cuff tear arthropathy), (2) failed hemiarthroplasty with irreparable rotator cuff tears, (3) pseudoparalysis due to massive, irreparable rotator cuff tears, (4) some reconstructions after tumor resection, and (5) some fractures of the shoulder not repairable or reconstructable with other techniques. This prosthesis can produce a significant reduction in pain and some improvement in function for most of the indications mentioned. However, the unique configuration and the challenge of its insertion can result in a high incidence of a wide variety of unusual complications. Some of these complications, such as dislocation of the components, are similar to conventional shoulder replacement. Other complications, such as notching of the scapula and acromial stress fractures, are unique to this prosthesis.Conclusion The configuration of the reverse prosthesis, its normal radiographic appearance and potential complications associated with its use are reviewed. 相似文献
9.
10.
Epithelial-speci c SHP1-P2 Methylation - a Novel Universal Tumor Marker for Detection of Colorectal Cancer Lymph Node Metastasis
下载免费PDF全文
![点击此处可从《Asian Pacific journal of cancer prevention》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Prakasit RattanatanyongSomboon KeelawatNakarin KitkumthornApiwat Mutirangura 《Asian Pacific journal of cancer prevention》2016,17(8):4117-4123
Background Methylation of promoter 2 of the SHP1 gene is epithelial cell speci c, with reported potential as a lymph node metastatic marker. Objective To demonstrate SHP1-P2 methylation-speci c quantitative PCR effectiveness in detecting colorectal cancer (CRC) DNA in lymph nodes. Materials and Methods SHP1-P2 methylation levels were measured in lymph nodes of CRC patients and compared with pathological ndings and patient prognosis. Results Lymph nodes of CRC metastatic patients without microscopically detectable cancer cells had higher SHP1-P2 methylation levels than lymph nodes of controls (<0.001). In addition, a higher SHP1-P2 methylation level was associated with a shorter duration until adverse disease events, metastasis, recurrence and death (r2 0.236 and p value 0.048). Studying two cohorts of 74 CRC patients without microscopic lymph node metastases showed that only the cohort containing samples with high SHP1-P2 methylation levels had a signi cant hazard ratio of 3.8 (95%CI 1.02 to 14.2). Conclusions SHP1-P2 methylation PCR can detectCRC cancer DNA in lymph nodes even if cancer cells are not visible under a microscope, con rming it's potential universal lymph node metastatic marker. 相似文献
1