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Oridate N Takeda H Asaka M Nishizawa N Mesuda Y Mori M Furuta Y Fukuda S 《Digestive diseases and sciences》2008,53(8):2033-2038
It is widely accepted that laryngopharyngeal reflux requires more aggressive and prolonged therapy than gastro-esophageal reflux disease. Otolaryngologists often observe that laryngopharyngeal symptoms, such as throat clearing, hoarseness, cough, and globus pharyngeus, are slower to resolve than esophageal symptoms, such as heartburn and regurgitation. The aim of this was to provide empirical evidence to support this observation and to carry out a detailed investigation of the differences between these symptoms. Forty-five patients with laryngopharyngeal and esophageal symptoms received acid-suppression therapy that involved the continuous administration of a proton-pump inhibitor for up to 6 months. We investigated the differences in response to acid-suppression therapy between patients suffering from laryngopharyngeal and esophageal symptoms, respectively, who received upper gastrointestinal endoscopy and were assayed for serum Helicobacter pylori antibodies. The significance of the rate of symptom improvement was estimated by Kaplan-Meier analysis and the logrank test. Laryngopharyngeal symptoms improved significantly more slowly than esophageal symptoms following acid-suppression therapy (49.8 vs. 78.3%, 60 days after the start of acid suppression; P = 0.003). These differences were observed both in patients with erosive esophagitis (P = 0.008) and in H. pylori-seronegative patients (P = 0.001). 相似文献
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Homma A Suzuki F Oridate N Furuta Y Inuyama Y Fukuda S 《Gan to kagaku ryoho. Cancer & chemotherapy》2002,29(8):1475-1478
A 60-year-old man had a recurrence of squamous cell carcinoma at the right side of the tongue base. Chemotherapy with TS-1 (100 mg/day) was begun. Each course of chemotherapy consisted of 4 weeks of TS-1, followed by 2 weeks of no treatment. After the completion of two courses, macroscopic examination revealed a complete response. From the third course of TS-1 treatment, the dose was increased to 120 mg/day. The complete response persisted on macroscopic examination. A biopsy done during the ninth course of TS-1 treatment confirmed the complete response histologically, with no evidence of malignancy. After 12 courses of TS-1 treatment, the drug was switched to 600 mg/day of UFT. Although there were no signs or symptoms of recurrence, the patient died of cancer of the pancreas. There was no recurrence of the oropharyngeal cancer, even at the time of death. 相似文献
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Homma A Furuta Y Suzuki F Oridate N Hatakeyama H Nagahashi T Ushikoshi S Asano T Nishioka T Shirato H Fukuda S 《Head & neck》2005,27(1):65-71
PURPOSE: The purpose of this study was to evaluate the efficacy of rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for previously untreated patients with advanced head and neck cancer. METHODS: Forty-three patients for whom surgery was contraindicated or who rejected radical surgery were given superselective intra-arterial infusions of cisplatin (100-120 mg/m2/week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity and conventional extra-beam radiotherapy (65 Gy/26 f/6.5 weeks). RESULTS: Thirty-nine patients had stage IV disease, and the remaining four had stage III disease. During the median follow-up period of 21 months, the 3-year locoregional progression-free rates of all patients (n = 43) and patients with unresectable disease (n = 24) were 68.9% and 56.4%, respectively. In addition, the 3-year overall survival of all patients and patients with unresectable disease was 54.0% and 39.6%, respectively. Thirty-five patients (81.4%) experienced nonhematologic grade III to IV toxicity, including mucositis (n = 16), nausea/vomiting (n = 8), and neurologic signs (n = 2). No patient died as a result of treatment toxicity. There are 29 surviving patients without evidence of disease, all of whom are able to have oral intake without feeding-tube support. CONCLUSIONS: We confirmed the efficacy of superselective arterial infusion and concomitant radiotherapy, which can concentrate the attack of supradose cisplatin on locoregional disease. Even patients with unresectable disease can be cured. Further studies are needed to establish the indications, long-term outcome, and possible late side effects of this treatment. 相似文献
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Voice restoration by primary insertion of indwelling voice prosthesis following circumferential pharyngolaryngectomy with free jejunal graft 总被引:1,自引:0,他引:1
Furuta Y Homma A Nagahashi T Oridate N Mesuda Y Nishizawa N Sekido M Yamamoto Y Okushiba S Fukuda S 《Auris, nasus, larynx》2005,32(3):269-274
BACKGROUND: Voice restoration after circumferential pharyngolaryngectomy (CPL) with free jejunal graft remains a difficult problem to solve. Few reports have analyzed the success rate and complications following primary insertion of indwelling voice prostheses during CPL with free jejunal graft. PATIENTS AND METHODS: Eight patients who underwent CPL with free jejunal graft had a Groningen voice prosthesis inserted as a tracheoesophageal (TE) shunt at the time of oncological surgery. A 10-point scale was used to assess each patient's speech intelligibility. Complications following the voice prosthesis insertion were also analyzed. RESULTS: Six of the eight patients (75%) achieved excellent speech intelligibility and the remaining two patients (25%) were judged as moderate. Six of the eight patients (75%) used the TE shunt as their major means of daily communication. Leakage through or around the prosthesis, which occurred in six (75%) patients, was the most frequent prosthesis-related complication. CONCLUSIONS: This safe and reliable technique can be effective in improving the quality of life in selected patients undergoing CPL. 相似文献
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Antisense epidermal growth factor receptor delivered by adenoviral vector blocks tumor growth in human gastric cancer. 总被引:7,自引:0,他引:7
T Hirao H Sawada F Koyama A Watanabe Y Yamada T Sakaguchi M Tatsumi H Fujimoto K Emoto M Narikiyo N Oridate H Nakano 《Cancer gene therapy》1999,6(5):423-427
Epidermal growth factor receptor (EGFR) protein overexpression is commonly found in human gastric cancer, and its gene amplification is known to correlate with poor prognosis in gastric cancer patients. With regard to therapy trials targeting EGFR, it has been reported that stable transfection of EGFR antisense or treatment with antibody against EGFR results in growth suppression of human cancer cells that express high levels of EGFR. We have designed an adenovirus-expressing antisense EGFR and have investigated its effect on the growth of gastric cancer in vitro and in vivo. Following infection with EGFR antisense RNA-expressing adenovirus (Ad-EAS), the cell surface EGFR protein levels of infected cancer cells were markedly reduced, and the in vitro growth of Ad-EAS-infected cells was significantly inhibited relative to control-infected cells in all three gastric cancer cell lines (AGS, KKLS, and MKN28) studied here (P < .0002). In a nude mouse subcutaneous tumor system, in vivo tumor growth of MKN28 was significantly inhibited after Ad-EAS treatment, and inhibition on day 48 was 93% by volume compared with that of untreated controls. These results suggest that an adenoviral vector system targeting the down-regulation of EGFR could be a good candidate for the therapy of gastric cancers that overexpress EGFR. 相似文献
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Takeda H Oridate N Shimizu Y Kato M Asaka M Fukuda S Yamamoto J 《Nihon rinsho. Japanese journal of clinical medicine》2007,65(5):921-925
Laryngopharyngeal reflux (LPR) or reflux laryngitis refers to the backflow of stomach contents into the larynx and hypopharynx. LPR is increasingly cited as the cause of laryngeal signs and symptoms such as globus sensation, hoarseness, chronic cough, chronic throat clearing, and throat pain. The diagnosis of LPR is often based on the presenting symptoms and associated laryngeal signs. An empiric trial of double-dose proton pump inhibitors (PPIs) has been recommended as a first line therapy in patients with suspected LPR. However, recent systemic review has shown no benefit of PPIs over placebo in the treatment of LPR. Clearly, more well designed, prospective large scale trials are warranted in the future. 相似文献
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Yoshihiro Chiba Daisuke Sano Yukiko Ikui Goshi Nishimura Kenichiro Yabuki Yasuhiro Arai Teruhiko Tanabe Hidetaka Ikemiyagi Hiroshi Hyakusoku Nobuhiko Oridate 《Auris, nasus, larynx》2018,45(6):1214-1220