Pharmacological properties and specific psychotropic activity of new derivatives of heterocyclic phenols with a bridging nitrogen atom

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 28, No. 10, pp. 23–26, October, 1994.     

Comparison of the results of provocation electrocardiographic tests with the questionnaire for detection of exertion-induced stenocardia (data of the epidemiological study)

The results of a combination of functional electrocardiographic tests were compared with those of a WHO questionnaire for angina of effort. Coronary disease was verified in 37% of patients with a double diagnosis of angina of effort, and in 100% of cases of angina of effort combined with ischemic electrocardiographic changes.     

Comparative evaluation of the anal sphincter function after sphincter-sparing operations in diffuse polyposis

Experience in treating 76 patients who were subjected to various sphincter-preserving operations is analysed. It is shown that after subtotal resection of the large intestine with ++abdomino-anal resection of the rectum and pull-through of the right parts of the colon into the anal canal as well as after pull-through of the segment of the transverse colon into the anal canal, the neuro-reflex activity of the musculus sphincter ani internus is destroyed in 55% and reduces in 25% of patients while the reflex activity of the musculus sphincter ani externus is disturbed in 45% of patients and is not restored later. The results bear evidence that the condition of the rectal obturation apparatus does not depend on the segment of the colon subjected to the pull-through operation (cecum, ascending colon, transverse colon). Experience has shown that the results of sphicterometry, electromyography, and electromanometry in various periods after colectomy, mucosectomy of the rectum, and formation of ileorectal anastomosis are much better than those after pull-through operations on various parts of the colon, and return to normal values in 18 months.     

Synthesis of 21-esters of hydrocortisone with glycine and glutamic acid and study of their pharmacological activity

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 24, No. 3, pp. 26–29, March, 1990.     

Determination of thrombocyte aggregation by a modification of K. Wu and J. Hoak's method]

The authors review the results of estimating platelet spontaneous aggregation by Wu and Hoak's method and by its modifications. They describe a modification of the procedure that essentially improves the accuracy of investigation, is sufficiently sensitive, simple, and rapid. Its informative value was confirmed in experiments with spontaneous platelet aggregation in rabbits with cholesterolemia.     

The efficacy of combined immunomodulatory therapy with timoptin and sodium nucleinate in patients with chronic obstructive bronchitis

Study of the immunologic reactivity of 104 patients with chronic obstructive bronchitis revealed the deficiency of cellular immunity for the most part. The use of timoptin, sodium nucleinate and their combined application raised the clinical efficacy of the treatment of patients with chronic obstructive bronchitis, significantly reduced the concentration of medium-weight molecules in blood serum, and corrected immunity disorders.