收费全文 | 239篇 |
免费 | 17篇 |
国内免费 | 1篇 |
儿科学 | 5篇 |
妇产科学 | 16篇 |
基础医学 | 27篇 |
口腔科学 | 9篇 |
临床医学 | 25篇 |
内科学 | 56篇 |
皮肤病学 | 1篇 |
神经病学 | 6篇 |
特种医学 | 5篇 |
外科学 | 19篇 |
综合类 | 1篇 |
预防医学 | 45篇 |
眼科学 | 5篇 |
药学 | 15篇 |
中国医学 | 1篇 |
肿瘤学 | 21篇 |
2023年 | 5篇 |
2022年 | 19篇 |
2021年 | 21篇 |
2020年 | 15篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 8篇 |
2016年 | 8篇 |
2015年 | 6篇 |
2014年 | 7篇 |
2013年 | 9篇 |
2012年 | 14篇 |
2011年 | 14篇 |
2010年 | 8篇 |
2009年 | 9篇 |
2008年 | 16篇 |
2007年 | 14篇 |
2006年 | 10篇 |
2005年 | 8篇 |
2004年 | 12篇 |
2003年 | 5篇 |
2002年 | 13篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1991年 | 1篇 |
1977年 | 1篇 |
1972年 | 1篇 |
1967年 | 1篇 |
Three new steroidal saponins, aspiletreins A–C (1–3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC50 values ranging from 7.69?±?0.40 to 20.46?±?3.11 µM.
相似文献Laparoscopic single-port surgery has widely been introduced for the treatment of various abdominal conditions. But controversies still exist regarding its potential advantages and risks, especially for emergency surgery. The aim of this study was to evaluate the results of a single-port laparoscopic repair using straight laparoscopic instruments for the treatment of perforated duodenal ulcers.
MethodsA prospective consecutive case series was conducted including all patients with a perforated duodenal ulcer who underwent a laparoscopic single-port repair at a single institution from January 2012 to June 2018. The operation was performed through a single port using conventional straight laparoscopic instruments and intra-corporeal knot tying techniques.
ResultsOut of 75 patients, simple closure of the perforation without omental patch was accomplished in 96% of cases. Conversion to an open operation was required in one patient (1.3%) due to a posterior duodenal perforation, and additional trocar placement was needed in another patient (1.3%). The mean incision length was 2.0 ± 0.2 cm. The mean operation time was 63.0 ± 26.6 min. Meantime a nasogastric tube remained in place was 2.9 ± 0.8 days. Mean duration of analgesic use was 2.8 ± 0.8 days. The rate of postoperative complications was 2.7%, including two patients with wound infections. There were no instances of intestinal leak or abscess. The postoperative hospital stay was 5.7 ± 1.2 days.
ConclusionLaparoscopic single-port repair using conventional straight laparoscopic instruments with intra-corporeal knot tying technique was safe and feasible for patients with perforated duodenal ulcers with low risk factors. This method offers results comparable to those expected with the standard multiport laparoscopic approach with the addition of improved cosmetic outcomes.
相似文献