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Patient safety is a fundamental aspect of a healthcare system. The aim of this study was to assess the perception and determinants of the patient safety culture of pharmacists in hospitals, in Riyadh, Saudi Arabia.A survey was conducted with pharmacists in the pharmacies of governmental, /military and private hospitals in Riyadh, Saudi Arabia. The pharmacy survey on patient safety culture questionnaire developed by Agency for Healthcare Research and Qualtity, a hard copy was distriuted to the pharmacists. The positive response rate (RR) was calculated and compared across hospitals using a chi-square test. The predictors of patient safety grades were identified using the generalized estimating equation. The data was analyzed using SAS.A total of 538 questionnaires were distributed, of which 411 responded (RR 76.4%). Of the participants, 229 (56%) were females. The majority 255 (62%) were in the 18 to 34 years age range, and 361 (88%) had a bachelor''s degree. The majority of the sample 376 (92%) was a pharmacist. The Positive RR (PRR) ranged between (25.6%–74%). The highest PRR was observed in teamwork (74.4%), followed by ‘staff, training and skills’ (68%), and ‘organizational learning continuous improvement’ (66%). The lowest PRR was observed in ‘staffing, work pressure, and pace’ (25.5%). Comparing the PPR of the various healthcare sectors, the governmental hospitals scored the highest in all patient safety domains. Generalized Estimating Equation analysis showed that with increase in scores of all patient safety culture domains increased the likelihood of reporting a better patient safety grade, whereas respondents’ demographic characteristics had no effect except the working experience years 6 years and above had odds of poor reporting of the patient safety grade (odds ratio = 2.54, 95% confience interval (1.543, 4.194), (P = .0003).The grades achieved in the various domains of patient safety culture by pharmacists in Riyadh are below the expected standard. The highest scores were achieved in teamwork, with the lowest scores in staffing, work pressure and pace. Overall, pharmacists in government hospital settings have a better perception of patient safety than their peers in other settings. These results provide the baseline evidence for developing future interventional studies aiming at improving patient safety culture in hospital pharmacy settings. 相似文献
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Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin. 总被引:3,自引:0,他引:3
Charles J Glueck Ping Wang Naila Goldenberg Luann Sieve 《Clinical and applied thrombosis/hemostasis》2004,10(4):323-334
Thrombophilia, hypofibrinolysis, and polycystic ovary syndrome (PCOS) are associated with recurrent pregnancy loss (RPL) and spontaneous abortion (SAB) alone and concurrently. The efficacy and safety of combined enoxaparin-metformin was prospectively assessed in women with PCOS with one or more previous SAB, thrombophilia, and/or hypofibrinolysis. Twenty-four white women with PCOS were studied; 23 with previous pregnancies, seven with RPL of unknown etiology (>/=three consecutive pregnancy losses <20 weeks' gestation), two with two consecutive SABs, 13 with one SAB, and one with one live birth (HELLP syndrome). Prospectively, metformin (1.5 to 2.55 g/day) was administered before and throughout gestation, with concurrent enoxaparin (60 mg/day) throughout gestation. The 24 cases differed from 93 normal white female controls for the factor V Leiden mutation, 17% vs. 2%, Fisher's p [p(f)] = .016, and for the 4G4G mutation of the plasminogen activator inhibitor-1 (PAI-1) gene (46% vs. 24%, Chi-square 4.63, p =. 031). The patients also differed from 44 normal white female controls for high levels (> 21.1 U/mL) of the PAI-1 gene product, plasminogen activator inhibitor activity (PAI-Fx) (33% vs. 8%, p(f) =. 018), and for high factor VIII (>150%) (22% vs. 0%, p(f) = .037). Of the 24 women, 23 had 65 previous pregnancies without metformin or enoxaparin, with 18 live births, 46 SAB (71%), and one elective abortion. On metforminenoxaparin, the same 23 women had 26 current pregnancies (28 fetuses), with 20 live births, two normal pregnancies 13 weeks or longer, and six SAB (21%), 3.4-fold lower than previous gestations (McNemar's S = 33.6, p <. 0001). There were no adverse maternal or fetal therapy effects. Enoxaparin-metformin reduces pregnancy loss in women with PCOS with one or more previous SAB, who also have thrombophilia and/or hypofibrinolysis. 相似文献
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Marili Funmilayo Zubair Olubunmi Atolani Sulyman Olalekan Ibrahim Olubunmi Stephen Oguntoye Halimat Amin Abdulrahim Rukayat Abiodun Oyegoke Gabriel Ademola Olatunji 《Sustainable Chemistry and Pharmacy》2018
The Principles of Green Chemistry was employed for the preparation of organic antiseptic soaps with improved skin sensitivity, reduced skin toxicity and improved biodegradability. Non-conventional and lesser known tropical seeds of Momordica charantia were used as the source of oil for the saponification processes. The fatty acid methyl esters of the oil were prepared via transesterification and subjected to GC–MS analysis to obtain the fatty acid composition of the oil and saponified products were subjected to various physicochemical and antimicrobial evaluations. The results indicated that stearic acid (18:0) and eleostearic acid (18:3) were the most abundant fatty acids making up 37.60% and 39.16%, respectively. Palmitic acid (16:0) 12.36%, oleic acid (18:1) 8.71%, linoleic acid (18:2) 0.67% and gamolenic acid (18:3) 1.50% were present in smaller amount in the oil. The oil is a viable source of polyunsaturated fatty acid which is required as essential fatty acids in the human body. The prepared soaps containing only natural additives (such as honey and shear butter) and components showed appreciable degree of hardness comparable to commercial Dudu Osun and the synthetic Lux soaps used as standards. This work demonstrates the probability of the preparation of green antiseptic soaps from the underutilized tropical seed of M. charantia. The seed oil and the allied products obviously have great potential for further advancement, development, research and applications in health and cosmetics sectors. The adopted approach could also assist maintaining a safe and healthy biotic and abiotic environment. 相似文献
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Johnathan M. Goldman Xiaodong Chen Jeffrey T. Register Vishwas Nesarikar Lavanya Iyer Yongmei Wu Naila Mugheirbi Jasmine Rowe 《Journal of pharmaceutical sciences》2019,108(4):1486-1495
We have implemented the use of a small-scale, 7-vial Micro Freeze Dryer (MicroFD®; Millrock Technology, Inc.) that has the capability to accurately control heat transfer during lyophilization. We demonstrate the ability to fine-tune the MicroFD® vial heat transfer coefficient (Kv) to match the Kv of vials in a LyoStar III laboratory-scale unit. When the MicroFD® is run under conditions that match the Kv of the LyoStar III, the resulting lyophilization performance between scales results in equivalent product temperature profiles and critical quality attributes for the same drying process. The proposed workflow demonstrates how exploitation of Kv control in the MicroFD® enables cycle development of at-scale lyophilization processes using only 7 product vials. By changing the MicroFD® Kv, laboratory and, potentially, manufacturing cycles may be simulated using only 7 product vials for tremendous active pharmaceutical ingredient savings, as long as at-scale heat transfer coefficients are well characterized. 相似文献
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