全文获取类型
收费全文 | 71篇 |
免费 | 4篇 |
专业分类
儿科学 | 6篇 |
妇产科学 | 1篇 |
基础医学 | 16篇 |
口腔科学 | 1篇 |
临床医学 | 1篇 |
内科学 | 16篇 |
皮肤病学 | 2篇 |
神经病学 | 5篇 |
外科学 | 15篇 |
预防医学 | 4篇 |
药学 | 3篇 |
肿瘤学 | 5篇 |
出版年
2021年 | 1篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2013年 | 1篇 |
2012年 | 1篇 |
2011年 | 2篇 |
2010年 | 2篇 |
2009年 | 2篇 |
2008年 | 1篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 6篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1977年 | 2篇 |
1974年 | 2篇 |
1959年 | 1篇 |
1958年 | 2篇 |
1957年 | 4篇 |
1956年 | 4篇 |
1955年 | 2篇 |
1954年 | 1篇 |
排序方式: 共有75条查询结果,搜索用时 0 毫秒
1.
KAZUMI NOGUCHI JUN-ICHI TERANISHI HIROJI UEMURA NAOYA FUJIKAWA KAZUO SAITO TETSUO MURAI 《International journal of urology》2006,13(9):1259-1261
Antiandrogen withdrawal syndrome (AWS) is a well-established phenomenon in prostate cancer. However, responses to AWS are usually of limited duration, and a complete response (CR) is extremely rare. We present two patients who exhibited a chemical CR for more than 2 years after the discontinuation of steroidal antiandrogen chlormadinone acetate use. Whether patients who respond to antiandrogen withdrawal include a group of patients with a better prognosis remains uncertain. However, considering that the usual survival period of patients with hormone-resistant prostate cancer is approximately 12 months, both of the patients reported here, who are present in excellent physical condition, exhibiting an improved quality of life, and attending their hospital as outpatients, obviously acquired a prolonged survival because of AWS. 相似文献
2.
We have studied the effects of different doses of thiopentoneon the increase in serum myoglobin after administration of suxamethoniumduring inhalation induction of anaesthesia in children. Forty-threechildren were anaesthetized with halothane and nitrous oxidein oxygen and allocated to four groups. group S received suxamethonium1 mg kg1 to facilitate intubation; group ST2 receivedthiopentone 2 mg kg1 and group ST4 received thiopentone4 mg kg1 before administration of suxamethonium 1 mgkg1; group N did not receive thiopentone or suxamethonium.Serum myoglobin and creatine kinase (CK) concentrations weremeasured until 60 min after the injection of suxamethonium.Both myoglobin and CK concentrations increased in the threegroups receiving suxamethonium. There were no significant differencesbetween groups S and ST2, but the myo globin concentration wasless in group ST4 than in groups S and ST2. A significant differencein CK concentration was found only between groups ST2 and ST4at 60min. In group N, both values remained reasonably constant.Thiopentone 4mg kg1, but not 2 mg kg1, attenuatedthe increase. The results indicate that to prevent a markedelevation in serum myoglobin after administration of suxamethonium,thiopentone 4 mg kg1 should be administered.
Presented in part at the Annual Meeting of the American Societyof Anesthesiology, October 1989 (Anesthesiology 1989; 71: A1046). 相似文献
3.
EIICHI ISHII YUTAKA HAYASHIDA YOSHIKUNI TORII KOHJI IRIE TOSHIYUKI OGAWA SHINICHI NOGUCHI MASAZUMI TSUNEYOSHI 《Pediatrics international》1997,39(4):466-471
Various types of fibromatosis have been reported in infancy and early childhood. We describe an infant with diffuse fibromatosis on the scalp. A one year and five months-old girl showed a diffuse and hard mass 3 × 5 cm in diameter and no tenderness on the scalp. Two months later, the size of the mass had increased and several other tumors appeared on the lateral head. The magnetic resonance imaging (MRI) disclosed that a large and diffuse tumor had spread from the frontal to occipital head; a ‘helmet-like’ configuration of the tumor was exhibited on sagittal MR images. The tumor showed high signal intensity on T2-weighted images and was enhanced with Gd-DTPA. Histological examination showed a fibroblastic proliferation with intervening thick collagen bundles. The patient was diagnosed as having diffuse fibromatosis. The tumor at the resection site immediately recurred, whereas the tumor in the frontal head showed marked regression. Three months after the resection, new tumors appeared in the occipital head. The size and number of these tumors have remained unchanged for more than 18 months. The sites and appearance of the tumors were identical to that of juvenile hyaline fibromatosis (JHF) in this patient. However, JHF usually includes fibroblasts associated with large amounts of hyalinized collagen-like material, which were not present in our patient. The different histology of JHF comparing our case and other reported cases may depend on the different phase of the disease progression at resection. Long-term observation is necessary for the appropriate diagnosis and evaluation of prognosis in this patient. 相似文献
4.
MASANORI NOGUCHI DAISUKE DEGUCHI JUNICHIRO TORIWAKI KENSAKU MORI YOSHITO MEKADA KEI MATSUOKA 《International journal of urology》2006,13(10):1296-1303
AIM: We evaluated a prostate biopsy strategy for cancer detection using a computer simulation system with virtual needle biopsy for three-dimensional (3D) prostate models. METHODS: Two 3D prostate models with a volume of 25 cc or 50 cc were constructed from computed tomographic images of radical prostatectomy specimens. The peripheral zone (PZ) and transition zone (TZ) were arranged in the prostate models according to the anatomical information. Four thousand patterns of cancer lesions were automatically inserted into each prostate model with a proportion of 75% in PZ and 25% in TZ. Average hit rates (AHR) in prostate models were evaluated both with an increased number of biopsy cores and various angles of virtual needle biopsy. The influence of adding secondary tumors for hit rates was also evaluated. RESULTS: For both sizes, the laterally angled biopsy in 4-8 core biopsy schemes showed higher AHR than the vertical plane biopsy, while the vertical plane biopsy in 10-18 core biopsy schemes showed higher AHR than the laterally angled biopsy. A higher number of biopsy cores increased the AHR of secondary tumors. CONCLUSIONS: Our results suggest that it is important in prostate cancer detection to change the needle placement according to the number of biopsy cores and the size of the prostate. 相似文献
5.
HIROMU INAI KOJI KAWAI YUKIO MORISHITA MICHIO NAGATA MASAYUKI NOGUCHI HIDEYUKI AKAZA 《International journal of urology》2005,12(8):765-767
A 22-year-old man was diagnosed with retroperitoneal seminoma associated with Klinefelter's syndrome. The tumor was 14 x 12 cm in size and surrounded the superior mesenteric artery. He received induction chemotherapy with bleomycin, etoposide and cisplatin (BEP) followed by salvage chemotherapy with paclitaxel, ifosfamide and cisplatin (TIP). The tumor considerably decreased in size and remains as a poorly defined plaque. At the time of writing, he is being followed closely and is free from progression. 相似文献
6.
Mayumi SUZUKI ;Yoshihiko ITO ;Tomomi FUJINO ;Masayuki ABE ;Keizo UMEGAKI ;Satomi ONOUE ;Hiroshi NOGUCHI ;Shizuo YAMADA 《中国药理学报》2009,(3):271-281
Saw palmetto extract (SPE), an extract from the ripe berries of the American dwarf palm, has been widely used as a therapeutic remedy for urinary dysfunction due to benign prostatic hyperplasia (BPH) in Europe. Numerous mechanisms of action have been proposed for SPE, including the inhibition of 5a-reductase. Today, al-adrenoceptor antagonists and muscarinic cholinoceptor antagonists are commonly used in the treatment of men with voiding symptoms secondary to BPH. The improvement of voiding symptoms in patients taking SPE may arise from its binding to pharmacologically relevant receptors in the lower urinary tract, such as al-adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine receptors and vanilloid receptors. Furthermore, oral administration of SPE has been shown to attenuate the up-regulation of α1-adrenoceptors in the rat prostate induced by testosterone. Thus, SPE at clinically relevant doses may exert a direct effect on the pharmacological receptors in the lower urinary tract, thereby improving urinary dysfunction in patients with BPH and an overactive bladder. SPE does not have interactions with co-administered drugs or serious adverse events in blood biochemical parameters, suggestive of its relative safety, even with long-term intake. Clinical trials (placebo-controlled and active-controlled trials) of SPE conducted in men with BPH were also reviewed. This review should contribute to the understanding of the pharmacological effects of SPE in the treatment of patients with BPH and associated lower urinary tract symptoms (LUTS). 相似文献
7.
Shirley C. PUA Tadasu FUJI Tsuyoshi AIBE Tetsuji AKIYAMA Takayoshi NOGUCHI Shinya TANAKA Kenzo HARIMA Toshiyuki SASAKI Satoshi KONDO Kayoko ADACHI Hiroko TANAKA Kiwamu OKITA 《Digestive endoscopy》1990,2(3):329-334
A 48-year-old chronic alcoholic with previous hepatitis B virus infection presented with recurrent episodes of obstructive jaundice secondary to hepatocellular carcinoma. The obstructive nature of the jaundice was confirmed by the peroral cholangioscopic findings of a friable nodular mass partially obstructing the right hepatic duct, and by relief of obstructive signs and symptoms after endoscopic sphincterotomy freed the common bile duct of “dark greenish formed materials”. 相似文献
8.
Immunohistochemical demonstration of epidermal growth factor and c-myc oncogene product in normal, benign and malignant thyroid tissues 总被引:1,自引:0,他引:1
Y. MIZUKAMI A. NONOMURA T. HASHIMOTO T. MICHIGISHI M. NOGUCHI F. MATSUBARA N. YANAIHARA 《Histopathology》1991,18(1):11-18
The expression of epidermal growth factor (EGF) and c-myc oncogene product was studied immunohistochemically in 65 benign and malignant human thyroids. Normal thyroid tissues were usually negative with each antibody. Benign and malignant neoplastic thyroid tissues demonstrated a high percentage of stained cells. However, there was no significant difference in positivity between benign and malignant neoplastic tissues. In Graves' disease 25% of the cases were positive for EGF, and 100% for c-myc product. The effect of EGF or c-myc expression on prognosis was also examined in 42 patients with papillary thyroid carcinoma. When the cases were divided into two groups with regard to their EGF staining score (highly-expressed and poorly-expressed groups), the frequency of highly-expressed tumours was significantly higher in the recurrence-positive group compared with the recurrence-free group (86% vs 57%), but there was no significant difference between the groups in respect of c-myc expression. 相似文献
9.
Katsuaki KANBE Kazuhiko INOUE Junji CHIBA Masahiko NOGUCHI Yoriko HIGUCHI Minako MURATA 《International journal of rheumatic diseases》2005,8(2):114-118
Aims: To investigate the efficacy and safety of leflunomide, including the side‐effects, we assessed 84 rheumatoid arthritis (RA) patients who received leflunomide treatment. Methods: We analyzed the C‐reactive protein (CRP), white blood cell count (WBC), KL‐6, and visual analogue scale (VAS) scores, modified Stanford Health Assessment Questionnaire (MHAQ) score, American Rheumatism Association score (ACR20 and ACR50) within a time course after treatment with leflunomide. We treated 84 RA patients, 12 male and 72 female from 28 to 81‐years‐old, with an average age of 63.5 years. The patients were divided into three groups: a group consisting of 38 patients who received 100 mg/day of leflunomide for 3 days followed by 20 mg/day thereafter; a second group of 11 patients who received a no‐loading dose of 10 mg/day; and a third group of 35 patients who received a no loading dose of 20 mg/day. Results: The 50% decrease of CRP seen in 2 weeks was 52% of the total of 84 patients. The WBC score did not change significantly after the medication was given. The KL‐6 score did not change significantly, either. The VAS pain score improved 4 weeks later, and then further improved 8 weeks later. Therefore, RA patients using leflunomide obtained pain relief 4 weeks after commencing medication. The MHAQ score did not change significantly until 8 weeks after the patients started the medication. ACR20 was 62% and ACR50 was 38% at 8 weeks after treatment. The side‐effects of leflunomide observed in our patients were rash, respiratory infection, diarrhea, nausea, alopecia, muscle pain, headache, dizziness and general fatigue. Twenty‐three out of 84 patients experienced side‐effects (27%), and 48/84 (57%) experienced withdrawal. In our hospital, there were no patients who developed severe interstitial pneumonia (IP) or who died after taking leflunomide; however, the incidence of side‐effects of the 100 mg/day loading dose (42.1%) was 2.5 times higher than in the patients who received 20 mg/day (17.1%) of a no‐loading dose. Conclusion: Because of this, it is possible that a 100 mg/day loading dose is a relatively high risk dose in terms of causing side‐effects, especially for severely ill RA patients with a high CRP level. 相似文献
10.
Shohei TOBU Mitsuru NOGUCHI Teppei HATADA Ken‐ichi MORI Manabu MATSUO Hideki SAKAI 《Lower urinary tract symptoms.》2013,5(2):90-95
Objectives: Signaling pathways in suburothelial layer are involved in the bladder sensory response. The expression of angiotensin II type 1 (AT1) receptors and connexin 43 (Cx43) in suburothelial myofibroblasts was investigated in an acute bladder inflammation model. Methods: Adult female Wistar rats underwent urethral catheterization and received 0.2 mL intravesical infusion of 0.4 M HCl to establish acute bladder inflammation model or 0.2 mL of sterile saline as control (n = 10 rats/group). Eight days after treatment, cystometry was performed. Suburothelial myofibroblasts were also collected and subjected to immunohistochemical staining to examine AT1 receptor and Cx43 expression. Results: Eight days after treatment with HCl to induce acute bladder inflammation, the frequency and basal pressure of the bladder was significantly increased compared with those in control rats. The number of suburothelial myofibroblasts was significantly increased in acute bladder inflammation rats, as was the expression of AT1 receptor and Cx43. Conclusion: These results suggest that the increased number of suburothelial myofibroblasts, upregulation of AT1 receptor and Cx43 expression may be associated with the pathogenesis of hyperactivation of bladder sensory signaling pathways in acute inflammatory bladder. 相似文献