全文获取类型
收费全文 | 4170篇 |
免费 | 254篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 72篇 |
妇产科学 | 72篇 |
基础医学 | 569篇 |
口腔科学 | 35篇 |
临床医学 | 362篇 |
内科学 | 1330篇 |
皮肤病学 | 76篇 |
神经病学 | 336篇 |
特种医学 | 101篇 |
外科学 | 353篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 403篇 |
眼科学 | 48篇 |
药学 | 211篇 |
中国医学 | 5篇 |
肿瘤学 | 410篇 |
出版年
2023年 | 15篇 |
2022年 | 54篇 |
2021年 | 130篇 |
2020年 | 67篇 |
2019年 | 136篇 |
2018年 | 121篇 |
2017年 | 91篇 |
2016年 | 80篇 |
2015年 | 86篇 |
2014年 | 146篇 |
2013年 | 190篇 |
2012年 | 299篇 |
2011年 | 325篇 |
2010年 | 179篇 |
2009年 | 172篇 |
2008年 | 262篇 |
2007年 | 254篇 |
2006年 | 261篇 |
2005年 | 238篇 |
2004年 | 237篇 |
2003年 | 187篇 |
2002年 | 229篇 |
2001年 | 80篇 |
2000年 | 73篇 |
1999年 | 90篇 |
1998年 | 41篇 |
1997年 | 37篇 |
1996年 | 38篇 |
1995年 | 39篇 |
1994年 | 17篇 |
1993年 | 13篇 |
1992年 | 48篇 |
1991年 | 30篇 |
1990年 | 29篇 |
1989年 | 29篇 |
1988年 | 21篇 |
1987年 | 21篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1977年 | 2篇 |
1975年 | 5篇 |
1970年 | 3篇 |
1966年 | 2篇 |
1933年 | 2篇 |
1930年 | 1篇 |
排序方式: 共有4434条查询结果,搜索用时 15 毫秒
1.
2.
Ignasi Esteban Carmen Pastor-Quiones Lorena Usero Montserrat Plana Felipe García Lorna Leal 《Viruses》2021,13(3)
Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure. 相似文献
3.
4.
5.
6.
M. A. Martín J. C. Rubio R. A. Wevers B. G. M. Van Engelen G. C. H. Steenbergen O. P. Van Diggelen M. De Visser C. De Die-Smulders A. Blázquez A. L. Andreu J. Arenas 《Annals of human genetics》2004,68(1):17-22
We report on 8 Dutch patients with McArdle's disease from 6 unrelated families. Molecular analysis revealed the presence of four previously described mutations: the common R49X mutation, the IVS14+1G>A mutation and the recently reported R269X and Y84X nonsense mutations; and two new molecular defects: a missense mutation R138W in the homozygous state in two siblings, and a frameshift mutation c.1797delT. This first genetic study of patients from The Netherlands with McArdle's disease confirms that the R49X mutation is also the most common in Dutch patients, and that there is genetic heterogeneity within this population. Moreover, our data support the hypothesis that the Y84X mutation is a relatively frequent mutation in McArdle's patients with a Central European background, and expand the already crowded map of mutations within the PYGM gene responsible for McArdle's disease. 相似文献
7.
Maria José GaldOn Estrella Durá Yolanda Andreu Maite Ferrando Rafael Poveda José Vicente Bagán 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2006,102(1):40-46
OBJECTIVE: This study analyzes the differences in psychological variables and symptomatology between temporomandibular disorder diagnosis subgroups. STUDY DESIGN: The sample included 114 temporomandibular disorder patients that were evaluated in coping, distress, and temporomandibular characteristics. Diagnostic muscular (n = 58) and articular (n = 56) subgroups were compared in these variables through a MANCOVA. RESULTS: Muscular patients show a higher level of general distress, specifically in the anxiety and somatization subscales and a more active coping style, with a tendency of a minor use of humor and a higher number of parafunctional habits, specifically, biting nails, hangnails, and lips. CONCLUSION: We discuss the differences found in order to design the targets of the psychological intervention of temporomandibular patients. 相似文献
8.
Adrià Arboix Lluis García-Eroles Emili Comes Montserrat Oliveres Miquel Balcells Gustavo Pacheco Cecilia Targa 《European journal of neurology》2003,10(4):429-435
We assessed predictors of spontaneous early neurological recovery after acute ischemic stroke by means of multivariate analysis in a cohort of 1,473 consecutive patients treated at one academic center. At hospital discharge, spontaneous neurological improvement or good outcome was defined as grades 0-2 of the Rankin scale, and poor outcome (no improvement or in-hospital death) as grades 3-5. Spontaneous recovery of neurological deficit at the time of discharge from the hospital was observed in 16% of patients with cerebral infarction (n = 238). Dysarthria-clumsy hand syndrome improved in 44% of patients and was the only variable significantly associated with in-hospital functional recovery in three logistic regression models that in addition to lacunar syndromes, included demographic variables, cardiovascular risk factors, and clinical variables [odds ratio (OR) 2.56], neuroimaging findings (OR 2.48), and outcome data (OR 2.39), respectively. Clinical factors related to severity of infarction available at stroke onset have a predominant influence upon in-hospital outcome and may help clinicians to assess prognosis more accurately. Our work gives a contribution into prognostic factors after acute ischemic stroke. With regard to patterns of stroke, dysarthria-clumsy hand syndrome was a significant predictor of spontaneous in-hospital recovery in ischemic stroke patients. 相似文献
9.
Alex Iranzo Esteban Mu?oz Joan Santamaria Isabel Vilaseca Montserrat Milà Eduardo Tolosa 《Movement disorders》2003,18(10):1179-1183
We evaluated the occurrence of REM sleep behaviour disorder (RBD) and vocal cord abductor paralysis (VCAP) in a group of 9 Machado-Joseph disease (MJD) patients. RBD was diagnosed by clinical history plus audiovisual polysomnography in 4 men and 1 woman (55%). While dreaming, 4 fell out of the bed and the other injured his arms. Laryngoscopy detected bilateral VCAP in 1 patient with stridor who required emergency tracheotomy, and partial vocal cord abductor restriction in 2. RBD and VCAP are two potentially injurious conditions that should be considered part of the clinical spectrum of MJD. 相似文献
10.