全文获取类型
收费全文 | 625篇 |
免费 | 22篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 17篇 |
基础医学 | 59篇 |
口腔科学 | 27篇 |
临床医学 | 41篇 |
内科学 | 117篇 |
神经病学 | 51篇 |
特种医学 | 21篇 |
外科学 | 126篇 |
综合类 | 1篇 |
预防医学 | 13篇 |
眼科学 | 8篇 |
药学 | 17篇 |
肿瘤学 | 146篇 |
出版年
2023年 | 2篇 |
2022年 | 6篇 |
2021年 | 5篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 13篇 |
2017年 | 10篇 |
2016年 | 16篇 |
2015年 | 19篇 |
2014年 | 20篇 |
2013年 | 27篇 |
2012年 | 35篇 |
2011年 | 51篇 |
2010年 | 36篇 |
2009年 | 24篇 |
2008年 | 27篇 |
2007年 | 54篇 |
2006年 | 39篇 |
2005年 | 33篇 |
2004年 | 27篇 |
2003年 | 32篇 |
2002年 | 32篇 |
2001年 | 8篇 |
2000年 | 12篇 |
1999年 | 12篇 |
1998年 | 4篇 |
1996年 | 4篇 |
1995年 | 7篇 |
1994年 | 10篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1983年 | 2篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 6篇 |
1973年 | 2篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1958年 | 1篇 |
排序方式: 共有648条查询结果,搜索用时 8 毫秒
1.
2.
Yamamoto H Okada M Kanehira A Yamada A Kawamura M 《The Annals of thoracic surgery》1999,68(6):2361-2363
A new technique of video-assisted thoracic sympathectomy through retrosternal pulmonary junction can be done safely using a scope guide and a flexible scope. Bilateral thoracic sympathectomy was performed, employing a single skin incision, in 18 patients with palmar hyperhidrosis. The advantages include minimal neuralgia and superior cosmesis. 相似文献
3.
Antitumor Immunity Induction by Intracellular Hyperthermia Using Magnetite Cationic Liposomes 总被引:10,自引:0,他引:10
Mitsugu Yanase Masashige Shinkai Hiroyuki Honda Toshihiko Wakabayashi Jun Yoshida Takeshi Kobayashi 《Cancer science》1998,89(7):775-782
Induction of antitumor immunity to T-9 rat glioma by intracellular hyperthermia using functional magnetic particles was investigated. Magnetite cationic liposomes (MCLs), which have a positive surface charge, were used as heating mediators for intracellular hyperthermia. Solid T-9 glioma tissues were formed subcutaneously on both femurs of female F344 rats, and MCLs were injected via a needle only into the left solid tumors (treatment side). The rats were then divided into two groups, which received no irradiation, or irradiation for 30 min given three times at 24-h intervals with an alternating magnetic field (118 kHz, 384 Oe). On the treatment side, the tumor tissue disappeared completely in many rats exposed to the magnetic field. The tumor tissue on the opposite side also disappeared completely, even though MCLs were not injected into the right solid tumors. To examine whether a long-lasting and tumor-specific immunity could be generated, the rats that had been cured by the hyperthermia treatment were rechallenged with T-9 cells 3 months later. After a period of transient growth, all tumors disappeared. Furthermore, immuno-cytochemical assay revealed that the immune response induced by the hyperthermia treatment was mediated by both CD8+ and CD4+ T cells and accompanied by a marked augmentation of tumor-selective cytotoxic T lymphocyte activity. These results suggest that our magnetic particles are potentially effective tools for hyperthermic treatment of solid tumors, because in addition to killing of the tumor cells by heat, a host immune response is induced. 相似文献
4.
In an ultrasonically activated device, electric energy is transformed to mechanical vibration, which is transmitted to the device's tip. By clamping the vessel between the tissue pad and vibrating blade, frictional heat is generated. This heat, significantly milder than that in electrocautery technique, is ideal for sealing the vessel. The ultrasonic vibration eventually divides the vessel. In the experimental studies, the cut end of medium-sized vessels divided by a scissor type ultrasonically activated device (USAD) withstood high intravascular pressure. However, our clinical experiences with the USADs suggest there are pitfalls including:--giving excessive tension to the vessel,--incomplete clamping of the vessel,--contacting the adjacent vessel with the back side of the active blade tip,--contacting the adjacent vessel with the blade tip. Some devices are described to prevent these pitfalls. 相似文献
5.
Shin-ichi Fukumoto Naoko Yamauchi Hisashi Moriguchi Yoshitaka Hippo Akira Watanabe Junji Shibahara Hirokazu Taniguchi Shumpei Ishikawa Hirotaka Ito Shogo Yamamoto Hiroko Iwanari Mitsugu Hironaka Yuichi Ishikawa Toshiro Niki Yasunori Sohara Tatsuhiko Kodama Masaharu Nishimura Masashi Fukayama Hirotoshi Dosaka-Akita Hiroyuki Aburatani 《Clinical cancer research》2005,11(5):1776-1785
PURPOSE: Squamous cell carcinoma (SCC) and adenocarcinoma of the lung are currently subject to similar treatment regimens despite distinct differences in histology and epidemiology. The aim of this study is to identify a molecular target with diagnostic and therapeutic values for SCC. EXPERIMENTAL DESIGN: Genes specifically up-regulated in SCC were explored through microarray analysis of 5 SCCs, 5 adenocarcinomas, 10 small cell lung carcinomas, 27 normal tissues, and 40 cancer cell lines. Clinical usefulness of these genes was subsequently examined mainly by immunohistochemical analysis. RESULTS: Seven genes, including aldo-keto reductase family 1, member B10 (AKR1B10), were identified as SCC-specific genes. AKR1B10 was further examined by immunohistochemical analysis of 101 non-small cell lung carcinomas (NSCLC) and its overexpression was observed in 27 of 32 (84.4%) SCCs and 19 of 65 (29.2%) adenocarcinomas. Multiple regression analysis showed that smoking was an independent variable responsible for AKR1B10 overexpression in NSCLCs (P < 0.01) and adenocarcinomas (P < 0.01). AKR1B10 staining was occasionally observed even in squamous metaplasia, a precancerous lesion of SCC. CONCLUSION: AKR1B10 was overexpressed in most cases with SCC, which is closely associated with smoking, and many adenocarcinoma cases of smokers. These results suggest that AKR1B10 is a potential diagnostic marker specific to smokers' NSCLCs and might be involved in tobacco-related carcinogenesis. 相似文献
6.
7.
8.
Takahiro Hayashi Masaru Miyataka Akio Kimura Mitsugu Taniguchi Atsuhiro Kurooka Hiroshi Yabushita Takashi Kiyoshima Hajime Nakamura Yutaka Hirano Kinji Ishikawa 《Circulation journal》2005,69(4):420-426
BACKGROUND: Many patients with acute myocardial infarction will still die after admission. Recent trends in hospital mortality were analyzed to identify aspects that need improvement. METHODS AND RESULTS: A total of 1,247 patients admitted to Kinki University School of Medicine within 24 h of the onset of infarction were analyzed between 1975 and 2001. The percentage of patients discharged with 100% occlusion decreased gradually from 31.3% during 1975-1982 to 2.1% during 1998-2001, while those with 50% stenosis or less gradually increased from 12.5% to 82.5% during the same period (trends: p < 0.01). The cardiac death rate was 17.1% in 1975-1982, and 7.7% in 1998-2001, showing a significant decrease with time (p < 0.01). This decrease was particularly marked among those admitted within 6 h of the onset of infarction. Death due to cardiac rupture decreased significantly with time (p < 0.001). In contrast, the non-cardiac death rate, amounting to 2.2% on average, did not decline. CONCLUSIONS: Cardiac deaths due to acute myocardial infarction have decreased markedly of late. However, patients must be admitted within 6 h of the onset of infarction to benefit from this improvement. More effort should be made to improve the general care of patients in order to reduce the incidence of non-cardiac death. 相似文献
9.
Intracontinental and intercontinental dissemination of Asian H5 highly pathogenic avian influenza virus (clade 2.3.4.4) in the winter of 2014–2015 下载免费PDF全文
Takehiko Saito Taichiro Tanikawa Yuko Uchida Nobuhiro Takemae Katsushi Kanehira Ryota Tsunekuni 《Reviews in medical virology》2015,25(6):388-405
Asian H5 highly pathogenic avian influenza viruses (HPAIVs) that possess the clade 2.3.4.4 HA gene have been identified in wild birds and poultry since late 2014 in both Europe and North America (N. America). Clade 2.3.4.4 H5 HPAIVs of the H5N8 subtype have been isolated in both regions, whereas reassortment viruses with NA N1 and N2 subtypes of the North American (N. American). avian lineage have only been identified in N. America. The HA genes of those isolates were closely related to genes of the HPAIVs that have caused massive outbreaks in poultry in Korea since January 2014. The outbreaks caused by those viruses and the genetic relatedness of their HA and NA genes are reviewed in this study. Although the illegal movement of poultry and poultry products cannot be ruled out as a cause of intercontinental and intracontinental dissemination of clade 2.3.4.4 H5 HPAIVs during the winter of 2014–2015, transmission of the viruses by infected migratory birds appears to be a more plausible mechanism for their dissemination. In particular, the involvement of migratory birds in HPAIV transmission between Asia and N. America is highly likely because of the reassortments between H5N8 HPAIV and the N. American lineage avian influenza viruses. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
10.