全文获取类型
收费全文 | 3802篇 |
免费 | 233篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 224篇 |
妇产科学 | 85篇 |
基础医学 | 511篇 |
口腔科学 | 153篇 |
临床医学 | 267篇 |
内科学 | 698篇 |
皮肤病学 | 204篇 |
神经病学 | 302篇 |
特种医学 | 233篇 |
外科学 | 489篇 |
综合类 | 26篇 |
一般理论 | 1篇 |
预防医学 | 203篇 |
眼科学 | 104篇 |
药学 | 317篇 |
中国医学 | 16篇 |
肿瘤学 | 150篇 |
出版年
2023年 | 28篇 |
2022年 | 54篇 |
2021年 | 89篇 |
2020年 | 86篇 |
2019年 | 74篇 |
2018年 | 132篇 |
2017年 | 96篇 |
2016年 | 156篇 |
2015年 | 135篇 |
2014年 | 198篇 |
2013年 | 246篇 |
2012年 | 239篇 |
2011年 | 269篇 |
2010年 | 184篇 |
2009年 | 117篇 |
2008年 | 188篇 |
2007年 | 205篇 |
2006年 | 221篇 |
2005年 | 191篇 |
2004年 | 157篇 |
2003年 | 121篇 |
2002年 | 130篇 |
2001年 | 73篇 |
2000年 | 83篇 |
1999年 | 84篇 |
1998年 | 22篇 |
1997年 | 19篇 |
1996年 | 15篇 |
1995年 | 18篇 |
1994年 | 20篇 |
1993年 | 11篇 |
1992年 | 35篇 |
1991年 | 21篇 |
1990年 | 14篇 |
1989年 | 16篇 |
1988年 | 24篇 |
1987年 | 12篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1983年 | 18篇 |
1982年 | 9篇 |
1975年 | 17篇 |
1974年 | 10篇 |
1973年 | 10篇 |
1972年 | 12篇 |
1971年 | 9篇 |
1970年 | 9篇 |
1969年 | 12篇 |
1968年 | 14篇 |
1967年 | 13篇 |
排序方式: 共有4052条查询结果,搜索用时 0 毫秒
1.
Onur Hapa Hüsamettin ?ak?c? Kaan Gidero?lu Kutay ?zturan Aysel Kükner Güler Bu?dayc? 《Archives of orthopaedic and trauma surgery》2009,129(12):1721-1726
Introduction
Ethanol has a suppressive effect on inflammation and the immune system, but the effect of ethanol on tendon healing in vivo has not been studied. The purpose of this study was to investigate the histological and biomechanical effects of ethanol intake on tendon healing in a rat tendon injury model. 相似文献2.
The effects of MPP+ (2.5–20 mg/kg) on the adrenal glands and heart were investigated in rats. At various periods after s.c. drug administration the rats were decapitated and tissue catecholamine levels were determined by means of HPLC with electrochemical detection. Adrenal dopamine (DA) levels were reduced at 2–8 h after MPP+ administration, but this decrease was followed by an elevation after 16 h and return to the control values after one week. Three successive injections of MPP+ caused a statistically significant elevation in adrenal DA, one day, with a tendency to elevation four and seven days after the last injection, whereas a severe (up to 96%) decrease in heart noradrenaline (NA) was found one day after the last injection. Seven days after the last injection a 50% depletion of NA in the heart was still observed. Pretreatment with GBR 12909 (30 mg/kg, 4 h) blocked the MPP+ (10 mg/kg, 2 h) induced reduction of adrenal DA levels, but at the same time GBR 12909 failed to block the effects of MPP+ in the heart. One day after three successive daily injections of MPP+ (10 mg/kg each), the DA-uptake inhibitor GBR 12909 (30 mg/kg, 6 h) could still induce an increase in adrenal DA.MPP+ appears to lack persistent cytotoxic action in the adrenal medulla but rather to cause a transient inhibition of DA synthesis followed by a compensatory stimulation. The inhibition can be blocked by specific inhibitor of the DA-uptake mechanism, suggesting a direct effect of MPP+ taken up by adrenomedullary cells. The data obtained so far do not suggest any involvement of peripheral dopaminergic nerves in the action of MPP+ on the adrenal medulla. The long-lasting depletion of the heart NA, however, suggests a lesion of peripheral noradrenergic nerves.Part of this work was presented at 6th International Symposium on Chromaffin Cell Biology, Marburg, Germany, 18–23 August 1991
Correspondence to: M. Kujacic at the above address 相似文献
3.
Introduction Hypothalamic hamartomas are congenital malformations. Clinically, they can be asymptomatic, but they cause seizures, mental
retardation and precocious puberty in many cases.
Case report A 20-day-old boy with hypothalamic hamartoma and bilateral anophthalmia was presented. Except those, no other congenital anomaly
was detected.
Conclusion This is a rare case of hypothalamic hamartoma with bilateral anophthalmia. The mutations at SOX2 has an important role in
the developing brain and eyes. 相似文献
4.
Hasan Yüksel Ali Riza Odaba?i Selda Demircan Aslihan Karul Leyla Didem Kozaci Kutsi K?seo?lu Kadir Kizilkaya Okay Ba?ak 《Gynecological endocrinology》2006,22(7):381-387
AIM: To evaluate the effects of oral continuous 17beta-estradiol plus norethisterone acetate (E2/NETA) replacement therapy on abdominal subcutaneous fat, serum leptin level (SLL) and body composition in postmenopausal women. MATERIALS AND METHODS: A 6-month, prospective, randomized, double-blind and placebo-controlled study was conducted. Forty-three healthy naturally postmenopausal women aged 43-65 years were randomly assigned to receive E2/NETA (2 mg E2 plus 1 mg NETA, n = 22) or placebo (n = 21). Fasting SLL by enzyme-linked immunosorbent assay, subcutaneous abdominal fat thickness (STh) by ultrasound and the anthropometric indices of body weight (BW), body mass index (BMI), waist and hip circumference (WC, HC) and waist-to-hip ratio (WHR) were recorded at the beginning and the end of the study. RESULTS: After 6 months of therapy, BW and SLL increased in the placebo group (p = 0.043 and 0.033, respectively). WC, HC and STh decreased significantly in the E2/NETA group (p = 0.002, 0.006 and 0.000, respectively) and they were also significantly lower in women receiving E2/NETA than in women taking placebo (p = 0.000, 0.034 and 0.000, respectively). At baseline, SLL and STh were positively correlated with all anthropometric indices except WHR. CONCLUSION: Oral continuous combined regimen of E2/NETA significantly reduced central fat accumulation as assessed by WC and STh, and attenuated the increase in SLL. The observed changes in SLL were highly and positively related to changes in STh. The oral continuous combined E2/NETA regimen appears to have protective effects on cardiovascular function and probably on metabolic diseases by its slimming effect upon WC in postmenopausal women. 相似文献
5.
6.
Mirna SuČIĆ Dubravka Boban Mirjana MarkoviĆ-glamoČak Mladen PetroveČki Matko MaruŠIĆ Boris Labar 《Medical oncology (Northwood, London, England)》1992,9(1):41-45
Cytochemical analysis of leukemic blasts from 46 patients with acute myeloblastic M2 leukemia (according to the FAB classification)
was performed before and after cytostatic therapy, and compared with findings obtained in 20 age- and sex-matched control
subjects. Cytochemical findings for myeloperoxidase (MPO), Sudan black B, acid phosphatase and alpha-naphthyl-acetate esterase
(ANAE) were related to the achievement of the first complete remission (CR),i.e. data were compared after the patients had been divided into CR and non-CR groups. The analysis clearly showed that a high
proportion of myeloperoxidase- and, to a lesser extent, Sudan black B-positive blasts before treatment may have constituted
a significantly unfavourable prognostic factor. 相似文献
7.
8.
9.
F. ČULO I. Klapan V. Katic T. Kolak B. Bakula 《Medical oncology (Northwood, London, England)》1992,9(1):35-39
The production of prostaglandin Eex vivo was studied in samples of 31 squamous cell carcinomas of the head and neck (SCCHN) and 12 adenocarcinomas of gastrointestinal tract (ACGI). As a control, the PGE production was measured in 22 samples of noninvolved mucosa in patients with SCCHN and 12 samples of gastrointestinal mucosas. The mean PGE production by SCCHN was significantly higher than in normal mucosa. Furthermore, the PGE production by tumors which recurred or spread to regional lymph node within 18 months after surgery was higher than in tumors which did not recur within that interval. Also, production of PGE by noninvolved mucosa was significantly higher in patients in which tumor recurred after surgery than in patients which were tumor free. On the other hand, the mean production of PGE by ACGI was not different from that of normal mucosa. These data show that determination of PGE production might have prognostic significance in SCCHN. 相似文献
10.