全文获取类型
收费全文 | 358篇 |
免费 | 12篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 11篇 |
妇产科学 | 3篇 |
基础医学 | 65篇 |
口腔科学 | 2篇 |
临床医学 | 24篇 |
内科学 | 88篇 |
皮肤病学 | 2篇 |
神经病学 | 44篇 |
特种医学 | 2篇 |
外科学 | 51篇 |
综合类 | 3篇 |
预防医学 | 27篇 |
药学 | 30篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 3篇 |
2022年 | 6篇 |
2021年 | 12篇 |
2020年 | 7篇 |
2019年 | 11篇 |
2018年 | 6篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 10篇 |
2014年 | 12篇 |
2013年 | 17篇 |
2012年 | 29篇 |
2011年 | 12篇 |
2010年 | 17篇 |
2009年 | 10篇 |
2008年 | 24篇 |
2007年 | 21篇 |
2006年 | 16篇 |
2005年 | 11篇 |
2004年 | 8篇 |
2003年 | 15篇 |
2002年 | 12篇 |
2001年 | 12篇 |
2000年 | 11篇 |
1999年 | 6篇 |
1997年 | 2篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 4篇 |
1968年 | 6篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1965年 | 2篇 |
1964年 | 2篇 |
1962年 | 2篇 |
排序方式: 共有375条查询结果,搜索用时 15 毫秒
1.
Systemic lupus erythematosus (SLE) and systemic sclerosis (SS) are autoimmune diseases characterized by the presence of antibodies against ubiquitous self antigens. The presence of clastogenic factors (CF) capable of inducing chromosome breakage has also been reported in the plasma of some patients. We aimed to assess basal frequency of cytogenetic damage in lymphocytes and presence of CF in the plasma of two groups of SLE and SS patients displaying a different antibody status (ACA-/Scl70+ or ACA+/Scl70-), using the micronucleus (MN) assay and FISH analysis with a pancentromeric DNA probe. As compared with controls, we found significantly higher MN frequencies in SS patients, but not in SLE patients. In addition, our data showed a significant prevalence of C-MN in SLE and ACA-/Scl70+ patients and of C + MN in ACA+/Scl70- patients. We observed a positive response in three out of the five CF experiments performed on plasma of SS patients. The three patients whose plasma caused MN induction were subtyped as ACA-/Scl70+, whereas the other subjects had ACAs. The same tests on six SLE patients gave negative results. 相似文献
2.
3.
Marcello Migliore Damiano Calvo Alessandra Criscione Francesco Borrata 《Journal of thoracic disease》2015,7(9):E378-E380
The uniportal-video assisted thoracic surgery (VATS) technique comprises operations which can be performed with skin incisions ranging from 2 to 8 cm and the manifest result of the introduction of the uniportal lobectomy had made possible to increase rapidly the number of published papers on this subject. Many of the large ensuing literature report incomplete historical information on uniportal VATS, and doubts exist about the indication of uniportal VATS for some thoracic oncologic pathologies. Known limitations have been overcome. On the other hand, the modern thoracic surgical team includes one surgeon, one assistant and a scrub nurse, and it is clear that the new generation of thoracic surgeons need to use the “less” used hand. The new technology which permitted the introduction of the uniportal VATS could influence the future need of thoracic surgeons worldwide. 相似文献
4.
5.
Bin Li Yang Yang Alper Toker Bentong Yu Chang Hyun Kang Ghulam Abbas Harmik J. Soukiasian Hecheng Li Hiroyuki Daiko Hongjing Jiang Jianhua Fu Jun Yi Kemp Kernstine Marcello Migliore Michael Bouvet Sara Ricciardi Yin-Kai Chao Yong-Hee Kim Yun Wang Zhentao Yu Abbas E. Abbas Inderpal S. Sarkaria Zhigang Li Cooperative Group of International Expert Consensus on Robot-assisted Esophagectomy for Esophageal Cancer 《Journal of thoracic disease》2020,12(12):7387
6.
7.
Marcello Migliore Alessandra Criscione Damiano Calvo Tom Routledge 《Updates in surgery》2013,65(1):59-61
Anterior mediastinotomy and VATS are today the most common surgical approaches to obtain tissue diagnosis or to remove mediastinal lesions. However, both methods lead to inconveniences. This report demonstrates the advantages of a minimal access mediastinotomy to remove or diagnose mediastinal lesions. 相似文献
8.
Alberto Migliore Eleonora Ballanti Bruno Laganà Luis Severino Martin Bruno Frediani 《Medical hypotheses》2014
Rheumatoid arthritis is a complex multifactorial disease, whose pathogenesis has not been fully elucidated. Biologic agents have revolutionized RA treatment, but a significant percentage of patients does not obtain an adequate response to the therapy. Most of the biologic agents do better if combined with conventional immunosuppressive DMARDs and they show a similar efficacy profile: most of the responders achieve the minimum desirable level of response (ACR20) and only few patients obtain a worthwhile clinical improvement (ACR70 or better). We need to identify new strategies of treatment, able to comply the non satisfied needs of RA patients. Taking inspiration from other medical fields, we could hypothesize a combined regimen in which biologic agents are administered simultaneously at a low or ultra-low dosage, targeting several pathogenetic mechanisms but avoiding important side effects. Alternatively it should be useful to identify rapid succession regimens in which biologic drugs are taken according to an established sequence. Research in this field is obviously not encouraged by pharmaceutical industries, but our efforts should be driven in this direction. According to these observations, adequate clinical trials should be designed to search for appropriate drugs associations and dosages. 相似文献
9.
Martin-Martin LS Latini A Pagano A Ragno A Stasi R Coppè A Davoli G Crescenzi A Alimonti A Migliore A 《Clinical rheumatology》2003,22(2):123-126
Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine glands. A diagnosis of SS in its early stages has a potential clinical relevance, but it is difficult and cannot be made solely on clinical grounds. Several sets of diagnostic criteria have been proposed, but none has met with a general consensus. Minor salivary gland has been judged to be the “gold standard” for the diagnosis of SS. However, it is a painful procedure and has a small but significant proportion of both false positive and false negative results. The aim of our study was to develop a simple mathematical score that uses clinical and laboratory variables for diagnosing SS, thereby reducing the need of minor salivary gland. The following variables were included in the model: ANA, SS-A/SS-B, Schirmer's Test/BUT, C3/C4, serum gammaglobulin levels. One hundred consecutive individuals reporting clinical syndromes consistent with a sicca syndrome were included in the study. The application of our multifactorial mathematical model has shown a high predictive value for SS vs controls or vs patients with other autoimmune disorders (Sensitivity 93%, Specificity 100%), with an estimated minor salivary gland reduction of 77%. We conclude that our mathematical model can be considered a useful non-invasive approach for diagnosing Sjogren's Syndrome and recommend its validation on a larger scale. 相似文献
10.
Ricardo A. Migliore María E. Adaniya Miguel Barranco Silvia Gonzlez Guillermo Miramont 《Archivos de cardiología de México》2022,92(1):26