全文获取类型
收费全文 | 118篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 3篇 |
基础医学 | 21篇 |
口腔科学 | 2篇 |
临床医学 | 14篇 |
内科学 | 26篇 |
神经病学 | 3篇 |
特种医学 | 26篇 |
外科学 | 14篇 |
预防医学 | 2篇 |
药学 | 3篇 |
肿瘤学 | 13篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 7篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 11篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 9篇 |
2014年 | 11篇 |
2013年 | 10篇 |
2012年 | 11篇 |
2011年 | 4篇 |
2010年 | 6篇 |
2009年 | 3篇 |
2008年 | 6篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2002年 | 4篇 |
2000年 | 6篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有129条查询结果,搜索用时 109 毫秒
1.
2.
Tsuyoshi Michinobu 《Macromolecular chemistry and physics.》2015,216(13):1381-1381
3.
Yuzo Yamasaki Satoshi Kawanami Takeshi Kamitani Koji Sagiyama Seitaro Shin Takuya Hino Hazumu Nagata Hidetake Yabuuchi Michinobu Nagao Hiroshi Honda 《The international journal of cardiovascular imaging》2018,34(9):1485-1491
To investigate the performance of second-generation 320-row computed tomographic (CT) angiography (CTA) in detecting coronary arteries and identify factors influencing visibility of the coronary arteries in infants with complex congenital heart disease (CHD). Data of 60 infants (aged 0–2 years, median 2 months) with complex CHD who underwent examination using 320-row CTA with low-dose prospective electrocardiogram-triggered volume target scanning were reviewed. The coronary arteries of each infant were assessed using a 0–4-point scoring system based on the number of coronary segments with a visible course. Clinical parameters, the CT value in the ascending aorta, image noise, and the radiation dose were subjected to univariate and multivariate analyses. The mean coronary score for all examinations was 2.6?±?1.5 points. The mean attenuation in the ascending aorta was 306.7?±?66.2 HU and the mean standard deviation was 21.7?±?4.4. The mean effective radiation dose was 1.27?±?0.39 mSv. Multivariate regression analysis showed significant correlations between coronary score and body weight (p?<?0.05) and between coronary score and the CT value in the ascending aorta (p?<?0.02). Second-generation 320-row CTA with prospective electrocardiogram-triggered volume target scanning and hybrid iterative reconstruction allows good visibility of the coronary arteries in infants with complex CHD. Body weight and the CT value in the ascending aorta are important factors influencing the visibility of the coronary arteries in infants. 相似文献
4.
5.
6.
Takuya Ishimoto Takayoshi Nakano Yukichi Umakoshi Masaya Yamamoto Yasuhiko Tabata 《Journal of bone and mineral research》2013,28(5):1170-1179
The aim of the present study was to assess the bone regeneration process in defects introduced into rabbit long bones, which were regenerated with controlled release of recombinant bone morphogenetic protein‐2 (rBMP‐2). The orientation of the biological apatite (BAp) c‐axis and bone mineral density (BMD) were compared as predictors of bone mechanical function. A 20‐mm‐long defect was introduced in rabbit ulnas, and 17 µg of rBMP‐2 was controlled‐released into the defect using a biodegradable gelatin hydrogel as the carrier. In the bone regeneration process, two characteristic phases may have been governed by different factors. First, new bone formation actively occurred, filling the bone defect with newly formed bone tissue and increasing the BMD. This process was regulated by the strong osteoinductive capacity of rBMP‐2. Second, after filling of the defect and moderate BMD restoration, preferential BAp c‐axis orientation began to increase, coincident with initiation of remodeling. In addition, the BAp c‐axis orientation, rather than BMD, was strongly correlated with Young's modulus, an important index of bone mechanical function, particularly in the later stage of bone regeneration. Thus, preferential BAp c‐axis orientation is a strong determinant and predictor of the mechanical function of tissue‐engineered bone. Therefore, analysis of BAp preferential c‐axis orientation in addition to measurement of BMD is crucial in assessment of bone mechanical function. © 2013 American Society for Bone and Mineral Research © 2013 American Society for Bone and Mineral Research 相似文献
7.
Shunsei Hirohata Tamiko Yanagida Michinobu Koda Masahito Koiwa Shin'Ichi Yoshino Tkahiro Ochi 《Arthritis \u0026amp; Rheumatology》1995,38(3):384-388
Objective. To determine the capacity of CD14+ monocyte-lineage cells induced from bone marrow of rheumatoid arthritis (RA) patients to stimulate the production of IgM rheumatoid factor (IgM-RF), in order to explore the functional abnormalities of CD14+ cells and gain insight into the mechanism of selective synthesis of IgM-RF in RA. Methods. CD14+ cells were induced by granulocyte–macrophage colony-stimulating factor (GM-CSF) stimulation of CD14– cells purified from bone marrow cells obtained from 6 RA patients and 6 osteoarthritis (OA) patients. The production of IgM and IgM-RF was induced by stimulating B cells from normal healthy individuals with immobilized anti-CD3-activated autologous CD4+ T cells. The effects of CD14+ cells on the proportion of IgM-RF to total IgM produced by the normal B cells were assessed. Results. CD14+ cells induced by GM-CSF stimulation of bone marrow CD14– cells from the 6 RA patients significantly enhanced the proportion of IgM-RF to total IgM produced by anti-CD3-activated CD4+ T cell-stimulated normal B cells (P < 0.05), whereas GM-CSF–induced CD14+ cells from the bone marrow of the 6 OA patients did not significantly affect IgM-RF production. CD14+ cells induced by GM-CSF obtained from different sites in the same RA patient on different occasions consistently enhanced the proportion of IgM-RF to IgM produced by B cells from different normal subjects. Conclusion. These results indicate that abnormal CD14+ monocytes stimulate RF-producing B cells to be ready to be activated by the signals delivered through noncognate TßB interactions with anti-CD3-activated T helper cells. Moreover, the data suggest that the accelerated generation of such functionally abnormal CD14+ cells from bone marrow precursors might play an important role in the pathogenesis of RA. 相似文献
8.
Michinobu Nagao Teruhito Kido Kouki Watanabe Hideyuki Saeki Hideki Okayama Akira Kurata Kohei Hosokawa Hiroshi Higashino Teruhito Mochizuki 《The international journal of cardiovascular imaging》2011,27(3):471-481
We attempted to assess coronary artery flow using adenosine-stress and dual-energy mode with dual-source CT (DE-CT). Data
of 18 patients with suspected coronary arteries disease who had undergone cardiac DE-CT were retrospectively analyzed. The
patients were divided into two groups: 10 patients who performed adenosine stress CT, and 8 patients who performed rest CT
as controls. We reconstructed an iodine map and composite images at 120 kV (120 kV images) using raw data with scan parameters
of 100 and 140 kV. We measured mean attenuation in the coronary artery proximal to the distal portion on both the iodine map
and 120 kV images. Coronary enhancement ratio (CER) was calculated by dividing mean attenuation in the coronary artery by
attenuation in the aortic root, and was used as an estimate of coronary enhancement. Coronary stenosis was identified as a
reduction in diameter of >50% on CT angiogram, and myocardial ischemia was diagnosed by adenosine-stress myocardial perfusion
scintigraphy. The iodine map showed that CER was significantly lower for ischemic territories (0.76 ± 0.06) or stenosed coronary
arteries (0.77 ± 0.06) than for non-ischemic territories (0.95 ± 0.21, P = 0.02) or non-stenosed coronary arteries (1.07 ± 0.33, P < 0.001). The 120 kV images showed no difference in CER between these two groups. Use of CER on the iodine map separated
ischemic territories from non-ischemic territories with a sensitivity of 86% and a specificity of 75%. Our quantification
is the first non-invasive analytical technique for assessment of coronary artery flow using cardiac CT. CER on the iodine
map is a candidate method for demonstration of alteration in coronary artery flow under adenosine stress, which is related
to the physiological significance of coronary artery disease. 相似文献
9.
Le Quoc Tuan Tran Thi Thanh Huong Pham Thi Anh Hong Tomonori Kawakami Toshinori Shimanouchi Hiroshi Umakoshi Ryoichi Kuboi 《Toxicology in vitro》2008,22(6):1632-1638
Arsenate is one of the most poisonous elements for living cells. When cells are exposed to arsenate, their life activities are immediately affected by various biochemical reactions, such as the binding of arsenic to membranes and the substitution of arsenic for phosphate or the choline head of phospholipids in the biological membranes. The effects of arsenate on the life activities of algae Chlorella vulgaris were investigated at various concentrations and exposure times. The results demonstrated that the living activities of algal cells (10(10)cells/L) were seriously affected by arsenate at a concentration of more than 7.5mg As/L within 24h. Algal cells and the artificial membranes (liposomes) were exposed to arsenate to evaluate its effects on the membrane fluidization. In the presence of arsenate, the membranes were fluidized due to the binding and substitution of arsenate groups for phosphates or the choline head on the their membrane surface. This fluidization of the biological membranes was considered to enhance the transport of toxicants across the membrane of algal cells. 相似文献
10.
This review article describes a method for quantifying heterogeneous distribution on Technegas (99mTc-carbon particle radioaerosol) SPECT images by three-dimensional fractal analysis (3D-FA). Technegas SPECT was performed to quantify the severity of pulmonary emphysema. We delineated the SPECT images by using five cut-offs (15, 20, 25, 30 and 35% of the maximal voxel radioactivity), and measured the total number of voxels in the areas surrounded by the contours obtained with each cut-off level. We calculated fractal dimensions from the relationship between the total number of voxels and the cut-off levels transformed into natural logarithms. The fractal dimension derived from 3D-FA is the relative and objective measurement, which can assess the heterogeneous distribution on Technegas SPECT images. The fractal dimension strongly correlate pulmonary function in patients with emphysema and well documented the overall and regional severity of emphysema. 相似文献