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排序方式: 共有1243条查询结果,搜索用时 15 毫秒
1.
Pseudomembranous colitis is not a rare complication of antibiotic therapy. 2000 surgical procedures with implantation of grafts in the aorto-iliac region were performed from 1974 through 1988; during this period 11 cases of CMP were observed. The Authors report their experience in regard to the various antibiotics administered. 相似文献
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Background
Official guidelines that promote evidence-based and cost-effective prescribing are of main relevance for obvious reasons. However, to what extent these guidelines are followed and their conditioning factors at different levels of the health care system are still insufficiently known. 相似文献5.
S Bonassi F Merlo N Pearce R Puntoni 《International journal of cancer. Journal international du cancer》1989,44(4):648-651
The association between occupational exposure to polycyclic aromatic hydrocarbons (PAH) and bladder cancer development was investigated in a population-based case-control study carried out in the Bormida valley, Italy. One hundred and twenty-one male cases and 342 male controls, matched age, were collected from local hospitals. Occupational exposure to PAH and aromatic amines (AA) was evaluated by means of a job exposure matrix, constructed specifically for this study. Subjects considered as sharing a "definite exposure to PAH" showed an increased risk even after adjustment for cigarette smoking and exposure to AA (OR = 2.14, 95% CL 0.82-5.60). No elevation in risk was found for the category "possible exposure to PAH" (OR = 1.05, 95% CL 0.45-2.44). The findings of this study are consistent with previous studies indicating PAH as a risk factor for bladder cancer. A possible residual confounding effect due to AA impurities is discussed. 相似文献
6.
Epitope focus, clonal composition and Th1 phenotype of the human CD4 response to the secretory mycobacterial antigen Ag85 总被引:4,自引:0,他引:4
Valle MT Megiovanni AM Merlo A Li Pira G Bottone L Angelini G Bracci L Lozzi L Huygen K Manca F 《Clinical and experimental immunology》2001,123(2):226-232
Lymphoproliferation of healthy donors was tested against mycobacterial antigens (PPD, Ag85, Ag85 peptides). All PPD responders recognized the secretory antigen Ag85 and the peptide specificity for Ag85B was defined. Peptide 91-108 was recognized by 85% of donors. In addition, all CD4 T cell lines generated from 12 donors against PPD or Ag85 responded to 91-108. When this peptide was used to generate T cell lines, the cells responded also to tuberculins from atypical mycobacterial species. Thus the cross-reactive peptide behaved as quasi-universal. The analysis of TCR-BV gene usage by cell lines showed that most Ag85-specific T cells correspond to 91-108-specific clonotypes. Intracytoplasmic staining of cell lines after phorbol myristate acetate stimulation resulted in dominance of interferon-gamma (IFN-gamma)-IL-4 double-positive cells, whereas antigen stimulation resulted in production of IFN-gamma only. The data show that peptide 91-108 is the major focus of the CD4 response to mycobacterial antigens in peripheral blood mononuclear cells and in T cell lines from PPD responders. 相似文献
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Aravind Krishnan Joshua Hsu Jinny S. Ha Stephen R. Broderick Pali D. Shah Robert SD. Higgins Christian A. Merlo Errol L. Bush 《American journal of surgery》2021,221(4):731-736
PurposeWe aimed to assess the prognostic value of Neutrophil to Lymphocyte Ratio (NLR) on long-term outcomes and graft dysfunction after lung transplantation.MethodsWe retrospectively reviewed all patients receiving a lung transplant at our institution from 2011 to 2014. The primary exposure was elevated NLR at the time of transplant, defined by NLR>4. The primary outcomes were graft failure and three-year all-cause mortality. Multivariate logistic regression and Kaplan-Meier survival analysis were used to analyze outcomes.Results95 patients were included. 40 patients (42%) had an elevated NLR. Elevated NLR was associated with graft failure (OR: 4.7 [1.2–18.8], p = 0.02), and three-year mortality (OR: 5.4 [1.3–23.2], p = 0.03) on multivariate logistic regression. Patients with elevated NLR demonstrated significantly lower survival on Kaplan-Meier analysis (50% versus 74%, p = 0.02). The c-statistic for our multivariate model was 0.91.ConclusionElevated neutrophil to lymphocyte ratio is associated with poor long-term survival and graft failure after lung transplantation. 相似文献
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Basolo F Venesio T Calvo S Fiore L Fontanini G Ciardiello F Toniolo A Liscia D Merlo G 《International journal of oncology》1994,4(6):1365-1370
Fibroblast growth factors (FGFs) are related polypeptides with mitogenic activity on cells of mesodermal and neuroectodermal origin. The Fgf-3 gene shares high homology with FGF-2 and its protein product can substitute FGF-2 as a growth factor. Other observations, however, indicate that Fgf-3 has specialized functions. We have investigated the effect of the expression and secretion of Fgf-3 on the growth and transformation of the human breast epithelial cell line MCF-10A. Overexpression of Fgf-3 stimulates proliferation of these cells in serum-free medium and induces anchorage-independent colony formation in soft agar. In contrast, these effects were not observed with purified FGF-1 and FGF-2 on either the parental or the Fgf-3-MCF-10A cells. Thus, Fgf-3 is distinct from FGF-1 and FGF-2 for its ability to induce cell proliferation and transformation of MCF-10A cells. This difference could be due, at least in part, to the expression of a specific set of FGF receptors with higher affinity for FGF-3 than FGF-1 or FGF-2. 相似文献
10.
Merlo J Lindberg G Lindblad U Lindgren A Råstam L Melander A 《European journal of clinical pharmacology》1999,55(1):69-76
Objective: To perform an ecological study in an effort to generate questions concerning the preventive impact of various cardiovascular
drugs on mortality from stroke and ischaemic heart disease (IHD) in the community, and to explore the association between
sales of nitrates and mortality from stroke and IHD.
Methods: Out-patient drug utilization (sales) of blood pressure lowering drugs, lipid lowering drugs and nitrates were categorized
in four groups of equal size by quartiles and compared with mortality from IHD and stroke, using the group of municipalities
with the lowest utilization as reference, from 1989 to 1993 in 283 of Sweden's 288 municipalities, by Poisson regression.
Adjustments were made for population size, age and gender proportions, the utilization rate of cardiovascular drugs other
than the tested drug group and location of the municipality.
Results: Compared with the group of municipalities with the lowest sales and adjusting only for population size, mortality from IHD
and stroke increased with the extent of utilization of blood pressure lowering drugs and nitrates. In contrast, mortality
decreased with increased utilization of lipid lowering drugs. After further adjustments by percentage of men, age structure,
geographical location (mid-points) of the municipalities, and, as a proxy for cardiovascular disease, the sales of cardiovascular
drugs other than the tested drug group, the increased risk associated with blood pressure lowering drugs disappeared, and
there was a dose-response association between sales of diuretics and old antihypertensives and decreasing mortality, sales
of nitrates continued to be associated with an increased risk, and the low mortality risk associated with sales of lipid lowering
drugs persisted.
Conclusion: Lipid lowering drugs may have a preventive impact in the general population, but the preventive impact of blood pressure
lowering drugs, with the exception of diuretics and old antihypertensives, may be low in many municipalities. The safety of
nitrates needs more investigation at the individual level.
Received: 16 April 1998 / Accepted in revised form: 10 November 1998 相似文献