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S Gunasti† SS Marakli† I Tuncer‡ N Ozpoyraz§ VL Aksungur† 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):811-817
BACKGROUND: We have seen several patients with itchy lichenified plaques located bilaterally on the elbows and/or knees and have named this condition 'psoriatic neurodermatitis' (PN). OBJECTIVE: The purpose of this study was to compare clinical and histopathological characteristics of these patients to those of patients with typical lichen simplex chronicus (LSC). METHODS: Nineteen patients with PN and 34 patients with typical LSC were included. Besides clinical dermatological evaluation, the prick test was carried out on 49 patients; the Phadiatop test on 40 patients; the patch test with European standard series on 47 patients; histopathological evaluation on 39 patients; and clinical psychiatric examination on 38 patients. RESULTS: Almost exclusively, PN was seen in females and was located on the extremities. It caused more plaques than typical LSC did. In PN, the plaques were smaller, sharper, more keratotic and less excoriated, and had fewer lichenoid papules around them. Itching was usually more severe in the evening, while resting and in a hot environment in typical LSC, but not in PN. In plaques of PN, microabscesses in the horny layer, hypogranulosis, regular acanthosis and thinning of the suprapapillary plates were more frequent, and hyperpigmentation in the basal layer was less. In patients with PN, depressive disorder was found more frequently; and generalized anxiety disorder or psychosomatic characteristics, less. There were no significant differences in the results of prick, Phadiatop and patch tests between patients with PN and those with typical LSC. CONCLUSION: In our opinion, it is most likely that the so-called PN is itchy psoriasis superimposed by LSC. 相似文献
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The neuronal impulse activity during visual testing for orientation sensitivity in different head tilts was recorded in parkinsonian++ patients diagnosed and treated with long-term intracerebral electrodes implanted into different nuclei of the thalamus and striopallidar complex. It was revealed that some neuronal populations responded only to the definite orientation of the stimuli. The "preferable" orientations were not changed for the most orientation-selective neurons during left and right head positions differing by 90 degrees. 相似文献
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P. A. Galenko-Yaróshevskii I. S. Chekman O. S. Medvedev V. I. Kondratyuk K. S. Vas'kov A. V. Uvarov S. E. Gumenyuk V. N. Kovalenko P. B. Popov V. L. Popkov 《Bulletin of experimental biology and medicine》1998,126(4):1017-1020
Sodium succinate improves the survival of a skin graft in mice, rats, and dogs normalizes histamine and serotonin concentrations
in the epidermis and blood, exhibits antitoxic activity, improves microcirculation in the skin, brain, heart, kidneys, and
testes without any appreciable effect on systemic arterial pressure, cardiac function, and liver blood flow in rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 10, pp. 420–424, October, 1998 相似文献
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N. N. Lobanova N. I. Medvedev V. I. Popov A. N. Murashev 《Bulletin of experimental biology and medicine》2008,146(6):691-694
Bilateral occlusion of carotid arteries in awake hypertensive rats (SHR-SP) was used as a model of global brain ischemia (duration
of occlusion — until appearance of seizures). In normotensive rats (WKY), no seizures developed over 60 min. We revealed swelling
of mitochondria in dendrites of hippocampal CA1 pyramidal cells, which was more pronounced in SHP-SP than in WKY rats. Blood
pressure and heart rate in SHR-SP rats increased starting from the first minutes of occlusion, while in WKY rats these parameters
remained unchanged. We proved that bilateral occlusion of the carotid arteries in awake SHR-SP rats can be used as an adequate
model of global cerebral ischemia.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 627–630, December, 2008 相似文献