全文获取类型
收费全文 | 11031篇 |
免费 | 637篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 111篇 |
儿科学 | 243篇 |
妇产科学 | 132篇 |
基础医学 | 1380篇 |
口腔科学 | 371篇 |
临床医学 | 696篇 |
内科学 | 2659篇 |
皮肤病学 | 278篇 |
神经病学 | 1172篇 |
特种医学 | 438篇 |
外科学 | 1726篇 |
综合类 | 49篇 |
预防医学 | 408篇 |
眼科学 | 182篇 |
药学 | 752篇 |
中国医学 | 27篇 |
肿瘤学 | 1091篇 |
出版年
2023年 | 96篇 |
2022年 | 146篇 |
2021年 | 246篇 |
2020年 | 139篇 |
2019年 | 183篇 |
2018年 | 260篇 |
2017年 | 197篇 |
2016年 | 220篇 |
2015年 | 221篇 |
2014年 | 306篇 |
2013年 | 338篇 |
2012年 | 628篇 |
2011年 | 621篇 |
2010年 | 412篇 |
2009年 | 303篇 |
2008年 | 500篇 |
2007年 | 618篇 |
2006年 | 614篇 |
2005年 | 558篇 |
2004年 | 503篇 |
2003年 | 484篇 |
2002年 | 492篇 |
2001年 | 348篇 |
2000年 | 330篇 |
1999年 | 323篇 |
1998年 | 121篇 |
1997年 | 110篇 |
1996年 | 93篇 |
1995年 | 87篇 |
1994年 | 70篇 |
1993年 | 60篇 |
1992年 | 197篇 |
1991年 | 189篇 |
1990年 | 166篇 |
1989年 | 178篇 |
1988年 | 152篇 |
1987年 | 156篇 |
1986年 | 168篇 |
1985年 | 136篇 |
1984年 | 77篇 |
1983年 | 81篇 |
1982年 | 34篇 |
1979年 | 62篇 |
1978年 | 43篇 |
1977年 | 42篇 |
1974年 | 36篇 |
1973年 | 37篇 |
1970年 | 35篇 |
1969年 | 36篇 |
1968年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 20 毫秒
1.
Mariko Morimoto 《Health marketing quarterly》2020,37(2):108-123
AbstractThis research explores how the level of consumers’ need for cognition (NFC) is associated with celebrity endorser credibility and examines its effects on advertising-related attitudes. A 3 (endorser types: actor/actress, athlete, TV personality/talent) × 2 (endorser’s gender) factorial experiment with 435 Japanese consumers was conducted. Concerning Japanese OTC drug advertising, lower NFC individuals perceived celebrity endorsers as more credible in comparison to higher NFC individuals. The main effects of NFC and endorser type on endorser credibility existed; however, no interaction between the two variables was found. The endorser type had an influence on attitudes toward ads and the advertised brand. 相似文献
2.
3.
Kei Kamide Yoshihiro Kokubo Hironori Hanada Junko Nagura Jin Yang Shin Takiuchi Chihiro Tanaka Mariko Banno Yoshikazu Miwa Masayoshi Yoshii Tetsutaro Matayoshi Hisayo Yasuda Takeshi Horio Akira Okayama Hitonobu Tomoike Yuhei Kawano Toshiyuki Miyata 《Hypertension research》2006,29(4):243-252
Mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2, HSD11B2, cause a rare monogenic juvenile hypertensive syndrome called apparent mineralocorticoid excess (AME). In AME, defective HSD11B2 enzyme activity results in overstimulation of the mineralocorticoid receptor (MR) by cortisol, causing sodium retention, hypokalemia, and salt-dependent hypertension. Here, we have studied whether genetic variations in HDS11B2 are implicated in essential hypertension in Japanese hypertensives and the general population. By sequencing the entire coding region and the promoter region of HDS11B2 in 953 Japanese hypertensives, we identified five missense mutations in 11 patients (L14F, n = 5; R74H, n = 1; R147H, n = 3; T156I, n = 1; R335H, n = 1) and one novel frameshift mutation (4884Gdel, n = 1) in a heterozygous state, in addition to 19 genetic variations. All genetic variations identified were rare, with minor allele frequencies less than 0.005. Four of 12 patients with the missense/frameshift mutations showed renal failure. Four missense mutations, L14F, R74H, R147H, and R335H, were successfully genotyped in the general population, with a sample size of 3,655 individuals (2,175 normotensives and 1,480 hypertensives). Mutations L14F, R74H, R147H, and R335H were identified in hypertensives (n = 6, 8, 3, and 0, respectively) and normotensives (n = 8, 12, 5, and 0, respectively) with a similar frequency, suggesting that these missense mutations may not strongly affect the etiology of essential hypertension. Since the allele frequency of all of the genetic variations identified in this study was rare, an association study was not conducted. Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese. 相似文献
4.
5.
6.
Moussa Ndong Machiko Kazami Tsukasa Suzuki Mariko Uehara Shin-ichi Katsumata Hirohumi Inoue Ken-Ichi Kobayashi Tadahiro Tadokoro Kazuharu Suzuki Yuji Yamamoto 《Nutrition Research》2009,29(9):640-647
Iron deficiency (ID) is one of the most commonly known forms of nutritional deficiencies. Low body iron is thought to induce neurologic defects but may also play a protective role against cancer development by cell growth arrest. Thus, ID may affect cellular pathways controlling cell growth and proliferation, the mechanism of which is still not fully understood. The serine/threonine protein kinase Akt and its downstream target, the mammalian Target of Rapamycin (mTOR), is known to play a crucial role in the regulation of cell growth and survival. Therefore, we hypothesized that Akt/mTOR pathway could be influenced by ID. Three-week-old male Wistar-strain rats were divided into 3 groups and the 2 groups had free access to a control diet (C group) or an iron-deficient diet (D group). The third group (PF group) were pair-fed the control diet to the mean intake of the D group. After 4 weeks, rats were killed and their brains were sampled. In separate experiments, COS-1 cells were cultured with or without the iron chelator deferoxamine. Western blots of brain samples and COS-1 lysates were used to analyze the expression and phosphorylation state of Akt, TSC2, mTOR, and S6 kinase proteins implicated in the Akt/mTOR pathway. Using 2 different ID models, we show for the first time that iron deficiency depresses Akt activity in rats and in COS-1 cells, leading to a decrease in mTOR activity. 相似文献
7.
8.
9.
Seiichi Saito Shunichi Namiki Kenji Numahata Makoto Satoh Shigeto Ishidoya Akihiro Ito Haruo Nakagawa Yasuhiro Kaiho Takehiko Sanada Atsushi Yamada Yoichi Arai 《International journal of urology》2007,14(2):133-139
PURPOSE: To determine the effect of an interposition nerve graft on sexual function after radical prostatectomy. METHODS: This study includes 64 patients, without hormonal therapy, who underwent a radical prostatectomy and intraoperative electrophysiological confirmation of cavernous nerve preservation. Twelve patients underwent a unilateral interposition sural nerve graft (UNG) for the resected neurovascular bundle. Twenty-one and 31 patients underwent bilateral nerve-sparing (BNS) and unilateral nerve-sparing (UNS) surgery without a nerve graft, respectively. As the age of patients was significantly younger in the UNG group than in the other groups, age-matched analysis also was conducted. Sexual function, evaluated by a self-administered questionnaire using the University of California Los Angeles-Prostate Cancer Index, was compared statistically among the three groups. RESULTS: In the age-matched analysis, the postoperative sexual function (SXF) score of the UNG group showed an intermediate level of recovery between those of the BNS and UNS groups at 12 months and reached the same level as the score at 12 months of the BNS group at 18 months postoperatively. The difference in the SXF score between the UNG and UNS groups began to appear after 6 months postoperatively and increased steadily with time. However, the background factors, such as the baseline SXF score, the usage rate of phosphodiesterase 5 inhibitors, and the rate of comorbidities were different between the UNG and UNS groups. CONCLUSIONS: The difference of the SXF score between the UNG and UNS groups increased with time after 6 months postoperatively. However, it might be difficult at present to attribute a better recovery of the SXF score to the nerve graft because of the difference in the background factors between the groups. 相似文献