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Astrid Rauh-Pfeiffer Uschi Handel Hans Demmelmair Wolfgang Peissner Mareile Niesser Diego Moretti Vanessa Martens Sheila Wiseman Judith Weichert Moritz Heene Markus Bühner Berthold Koletzko 《European journal of nutrition》2014,53(7):1445-1456
Background
Suboptimal vitamin B status might affect cognitive performance in early childhood. We tested the hypothesis that short-term supplementation with folic acid and selected B vitamins improves cognitive function in healthy children in a population with relatively low folate status.Methods
We screened 1,002 kindergarten children for suboptimal folate status by assessing the total urinary para-aminobenzoylglutamate excretion. Two hundred and fifty low ranking subjects were recruited into a double blind, randomized, controlled trial to receive daily a sachet containing 220 μg folic acid, 1.1 mg vitamin B2, 0.73 mg B6, 1.2 μg B12 and 130 mg calcium, or calcium only for 3 months. Primary outcomes were changes in verbal IQ, short-term memory and processing speed between baseline and study end. Secondary outcomes were urinary markers of folate and vitamin B12 status, acetyl-para-aminobenzoylglutamate and methylmalonic acid, respectively, and, in a subgroup of 120 participants, blood folate and plasma homocysteine.Results
Pre- and post-intervention cognitive measurements were completed by 115 children in the intervention and 122 in the control group. Compared to control, median blood folate increased by about 50 % (P for difference, P < 0.0001). Homocysteine decreased by 1.1 μmol/L compared to baseline, no change was seen in the control group (P for difference P < 0.0001) and acetyl-para-aminobenzoylglutamate was 4 nmol/mmol higher compared to control at the end of the intervention (P < 0.0001). We found no relevant differences between the groups for the cognitive measures.Conclusion
Short-term improvement of folate and homocysteine status in healthy children does not appear to affect cognitive performance. 相似文献2.
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Geibel A Olschewski M Zehender M Wilsch M Odening K Heinrich F Kasper W Konstantinides S 《The American journal of cardiology》2007,99(1):103-107
The indications for thrombolytic treatment in normotensive patients with pulmonary embolism (PE) are still the subject of debate, and it also remains questionable whether the efficacy and safety of thrombolysis are similar in men and women. To address the latter issue, the present study analyzed a large population of 428 women and 291 men with acute submassive PE derived from a prospective multicenter registry. Initial treatment consisted either of thrombolysis (<24 hours after diagnosis) or heparin alone. Thirty-day overall mortality was almost identical (11%) in heparin-treated men and women. Early thrombolysis was associated with drastically reduced death rates (2.7% vs 11% in the heparin group, p = 0.033) in men, whereas the reduction was nonsignificant (p = 0.181) in women. Multivariate analysis revealed that early thrombolysis was independently associated with reduced mortality rates in men (odds ratio 0.21, 95% confidence interval 0.05 to 0.96). In comparison, its favorable effect in women was marginal (odds ratio 0.77, 95% confidence interval 0.30 to 1.97). Gender-specific differences were also observed with regard to the reduction of symptomatic PE recurrence (in men, from 21.6% to 8.2%, p = 0.009; in women, from 16.9% to 8.3%, p = 0.049). In contrast, thrombolysis resulted in a more than threefold increase in major bleeding in women (from 8.4% to 27.1%, p <0.001), a more pronounced effect than in men (from 6.9% to 15.1%, p = 0.055). In conclusion, the present study generated the hypothesis that women with submassive PE might benefit less from thrombolytic treatment in terms of survival and PE recurrence and that they could be exposed to a higher bleeding risk compared with men. 相似文献
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Mareile Weigt Paul Dietl Stefan Silbernagl Hans Oberleithner 《Pflügers Archiv : European journal of physiology》1987,408(6):609-614
Increased chronic intake of K+ induced H+ and K+ secretion in amphibian distal tubule, paralleled by an elevation of plasma aldosterone. The present experiments test whether the mineralocorticoid hormone is responsible for the alteration of ion transport. The blood capillaries of the isolated kidneys of NaCl-adapted (i.e. aldosterone-suppressed)Rana pipiens were perfused with HEPES-buffered amphibian Ringer solution (pH 7.8). Limiting intraluminal pH (pH1u) was measured continuously with pH-sensitive microelectrodes while aldosterone (3·10–7 to 3·10–6 mol/l) was applied in the peritubular perfusate. Concomitant with a decrease of the lumen-positive transepithelial potential (V
te) from 8.5±1.1 mV to 4.0±0.6 mV pH1u dropped from 7.73±0.02 to a new steady-state value of 7.17±0.05 within 60 to 180 min of aldosterone administration. Significant luminal acidification occurred already 20 min after application of aldosterone. Luminal addition of 10–3 mol/l amiloride reversed luminal acidification to a pH1u of 7.68±0.04; at the same timeV
te recovered partially. Pretreatment of the distal tubules with spironolactone prevented the aldosterone-induced acidification of the tubule fluid. We conclude that in early distal tubule of the amphibian kidney aldosterone — after interaction with cytoplasmic receptors — activates the luminal, amiloride-inhibitable Na+/H+ exchanger. This mechanism could explain enhanced H+ secretion found in the K+ adapted animal. 相似文献
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Renovanz Mirjam Hechtner Marlene Janko Mareile Kohlmann Karoline Coburger Jan Nadji-Ohl Minou König Jochem Ringel Florian Singer Susanne Hickmann Anne-Katrin 《Journal of neuro-oncology》2017,133(3):653-662
Journal of Neuro-Oncology - Objective of this study aimed at assessing glioma patients’ supportive care needs in a neurosurgical outpatient setting and identifying factors that are associated... 相似文献
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Ali Mohammad Javed Glóckner Mareile Schicht Martin Bräuer Lars Paulsen Friedrich 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2018,256(11):2097-2102
Graefe's Archive for Clinical and Experimental Ophthalmology - To investigate the presence and distribution of epithelial and non-epithelial cholinergic system and cholinergic brush cells in... 相似文献
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Klemmer JM Schmitz S Roth S Simons S Reineking N Eisert A Lang B Jaehde U 《Medizinische Monatsschrift für Pharmazeuten》2007,30(11):411-414
Geriatric patients are often treated with a variety of drugs. Due to the complex pharmacotherapy there is a high potential of drug-related problems such as drug-drug interactions, adverse effects and medication errors. This article describes how the drug therapy of a geriatric patient with Parkinson's disease was optimized using SOAP notes. 相似文献