全文获取类型
收费全文 | 1135篇 |
免费 | 59篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 36篇 |
妇产科学 | 25篇 |
基础医学 | 171篇 |
口腔科学 | 53篇 |
临床医学 | 112篇 |
内科学 | 309篇 |
皮肤病学 | 24篇 |
神经病学 | 36篇 |
特种医学 | 81篇 |
外科学 | 144篇 |
综合类 | 9篇 |
预防医学 | 52篇 |
眼科学 | 16篇 |
药学 | 42篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 81篇 |
出版年
2023年 | 7篇 |
2022年 | 7篇 |
2021年 | 25篇 |
2020年 | 20篇 |
2019年 | 21篇 |
2018年 | 29篇 |
2017年 | 20篇 |
2016年 | 23篇 |
2015年 | 55篇 |
2014年 | 48篇 |
2013年 | 77篇 |
2012年 | 82篇 |
2011年 | 58篇 |
2010年 | 55篇 |
2009年 | 37篇 |
2008年 | 65篇 |
2007年 | 38篇 |
2006年 | 48篇 |
2005年 | 55篇 |
2004年 | 47篇 |
2003年 | 40篇 |
2002年 | 24篇 |
2001年 | 21篇 |
2000年 | 12篇 |
1999年 | 22篇 |
1998年 | 29篇 |
1997年 | 27篇 |
1996年 | 35篇 |
1995年 | 17篇 |
1994年 | 22篇 |
1993年 | 15篇 |
1992年 | 11篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 6篇 |
1988年 | 15篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 11篇 |
1984年 | 5篇 |
1983年 | 10篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1977年 | 8篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有1197条查询结果,搜索用时 15 毫秒
1.
2.
M. I. Manrique-Poyato A. J. Muñoz-Pajares V. Loreto M. D. López-León J. Cabrero J. P. M. Camacho 《Chromosome research》2006,14(6):693-700
We have analysed B chromosome frequency for three consecutive years, B transmission rate at population and individual levels,
clutch size, egg fertility and embryo–adult viability in a natural population of the grasshopper Eyprepocnemis plorans containing two different B chromosome variants, i.e. B2 and B24, the second being derived from the first and having replaced it in nearby populations. From 2002 to 2003 the relative frequency
of both variants changed, although the differences did not reach significance. A mother–offspring analysis showed no significant
effect of any of the two B variants on clutch size, egg fertility or embryo–adult viability, but B24 was more efficiently transmitted than B2 through males from the 2002 season, which explains the observed frequency change. Controlled crosses, at individual level,
showed significant drive through some females for B24 but not for B2, suggesting that this difference in transmission rate might also be important for the substitution process. The analysis
of relative fitness for B2 and B24 carriers for all fitness components, as a whole, showed a significantly better performance of B24-carrying individuals, suggesting that the cumulative effect of these slight differences might contribute to the replacement
of B2 by B24.
Electronic Supplementary Material Supplementary material is available for this article at . 相似文献
3.
Golli M; Van Nhieu JT; Mathieu D; Zafrani ES; Cherqui D; Dhumeaux D; Vasile N; Rahmouni A 《Radiology》1994,190(3):741
4.
5.
6.
7.
8.
Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate 总被引:5,自引:2,他引:3
We observed that pretreatment of male F344 rats with benzyl selenocyanate,
a versatile organoselenium chemopreventive agent in several animal model
systems, decreases the levels of DNA and RNA modifications produced in the
liver by the hepatocarcinogen 2- nitropropane. To clarify the mechanisms
involved, we pretreated male F344 rats with either benzyl selenocyanate,
its sulfur analog benzyl thiocyanate, phenobarbital or cobalt
protoporphyrin IX; the latter is a depletor of P450. We then determined (1)
the ability of liver microsomes to denitrify 2-nitropropane, (2) effects on
2-nitropropane- induced liver DNA and RNA modifications and (3) amount of
nitrate excreted in rat urine following administration of the carcinogen.
Pretreatment with benzyl selenocyanate or phenobarbital increased the
denitrification activity of liver microsomes by 217 and 765%, respectively,
increased liver P4502B1 by 31- and 435-fold, respectively, decreased the
levels of 2-nitropropane-induced modifications in liver DNA (29-70% and
17-30%, respectively) and RNA (67-85% and 30-50%, respectively), and
increased the 24-h urinary excretion of nitrate by 157 and 209%,
respectively. Pretreatment with benzyl thiocyanate had no significant
effect on any of these parameters. Pretreatment with cobalt protoporphyrin
IX decreased liver P4502B 1 by 87%, decreased the denitrification activity
of liver microsomes by 76%, decreased the 24 h urinary excretion of nitrate
by 88.5%, but increased the extent of 2-nitropropane-induced liver nucleic
acid modifications by 17-67%. These results indicate that the metabolic
sequence from 2-nitropropane to the reactive species causing DNA and RNA
modifications does not involve the removal of the nitro group. Moreover,
they suggest that benzyl selenocyanate inhibits 2-NP-induced liver nucleic
acid modifications in part by increasing its detoxication through induction
of denitrification, although it is evident that other mechanisms must also
be involved.
相似文献
9.
M. E. Locatto V. Di Loreto M. C. Fernández D. Caferra R. C. Puche 《Acta diabetologica》1997,34(3):211-216
This report deals with the relationships between glucose (G) and insulin on the tubular transport of phosphate (P) in chronically
diabetic rats with high plasma levels of parathyroid hormone (PTH). Alloxan-induced diabetes leads to phosphorus depletion
of the soft tissues. This phenomenon appears associated with weight loss and negative P balances caused by the increased urinary
P excretion. Administration of 2 IU of insulin/100 g body weight (bw) to diabetic rats normalized their P balance and body
weight. The effect of parathyroid function on the P metabolism of diabetic rats was investigated with balance experiments.
Diabetic rats, intact or thyroparathyroidectomized (TPTX), have a greater urinary excretion of P than their controls. However,
in control rats, the ratio intact:TPTX for urinary P is 1.0:0.76, showing the antiphosphaturic effect of parathyroid ablation.
For diabetic animals, on the other hand, the ratio is 1.0:1.44. The simultaneous deficit of insulin and PTH thus quadruples
the urinary P loss, instead of compensating for each other. The contribution of insulin deficit and hyperglycemia to the defect
in tubular reabsorption (TRP) was investigated with clearance experiments (done on anesthetized, perfused rats). Five experimental
groups were used: Controls (C), diabetics (D), controls+glucose (C+G), diabetics+insulin (D+I) and diabetics+insulin+glucose
(D+I+G). All experimental groups showed a linear relationship between the TRP of P and G. The regression equation for C is
significantly different (F=40.1, P<0.001) from that of D animals. The slope value measure the number of μmoles of P per μmol of G reabsorbed. For C and D rats,
the ratio P:G approximates 1:4 and 1:20, respectively. The increase in P:G ratios represents the competition between both
substrates for tubular resorption. Glycemias up to 11 mM (C and D+I) exist concurrent with the P:G ratio 1:4. Glycemias above
25 mM (D, C+G and D+I+G) produce a P:G ratio of 1:20. Fractional excretion of P (FEP) increased significantly in untreated,
chronically diabetic rats (0.47± 0.12 vs controls=0.05±0.01, P<0.001). After a single intramuscular injection of insulin, the FEP decreased as a function of insulin levels. To normalize
the FEP of diabetic rats in short-term experiments, insulin had to be administered in doses that produce plasma insulin levels
25 times greater than normal. The general information afforded by the present experiments shows that in untreated, chronically
diabetic rats, insulin deficit plays an indirect role. The absence of PTH enhances the effect of hyperglycemia. The latter
and the concurrent tubular overload of glucose are the cause of hyperphosphaturia in these animals.
Received: 10 September 1996 / Accepted in revised form: 18 April 1997 相似文献
10.